BETA CELL REPLICATION AND MUTAGENESIS STUDIES IN E coli CELLS.

Laura Serna VélezMedicine Student

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INTRODUCTION

“TARGETING A CELL CICLE INHIBITOR PROMOTES BETA CELL REPLICATION.”

 Journal of clinical investigation.  16  January 2014.

“TARGETING A CELL CICLE INHIBITOR PROMOTES BETA CELL REPLICATION.”

 Journal of clinical investigation.  16  January 2014.

Beta cells are responsible for producing the insuline necesary for glucose entry into the cell.

In patients with diabetes, beta cells don't produce functional insuline and this problem can cause many alterations in the organism.

Researchers describe how in many new borns the glucose levels were low, but the number of beta cells were elevated. it was producing much insulin, making that the seric levels of glucose were low.

Beta cells in this new borns had a supression of p57, a cell cycle inhibitor, for that they could reproduce rapidly.

Beta cells from donnors were subjected to gene therapy were was supressed the p57.

“TARGETING A CELL CICLE INHIBITOR PROMOTES BETA CELL REPLICATION.”  Journal of clinical investigation.  16  January 2014

“TARGETING A CELL CICLE INHIBITOR PROMOTES BETA CELL REPLICATION.”  Journal of clinical investigation.  16  January 2014

Modified cells were transplantated into a diabetic mice.

RESULTS:After the transplant of the modified cells; the study showed that this cells had a rapid replication and responded efectively with glucose.

STUDENT COMMENT

I think that Its very important continue with this studies because in humans the

modified beta cells replication could improve the quality of life of many

people with diabetes.

 

«BMC STUDIES MUTAGENESIS IN RESTING E COLI CELLS»

January 28, 2014.

 

Researchers of BMC studied the way that the cell can generate DNA breaks when their stay in a resting state.

Generally the cells modify their DNA in the replication period.

The study was realiced in E coli cells and they found that this cell can modify their genetic material generating DNA breaks when they are not replicating their genetic information

Changes could be benefficious or could generate alterations such cancer, mutations and antibiotic resistance.

The team conclude that after the replication, the genetic material are more suceptible to suffer breaks.

STUDENT COMMENT

I think that the significance of these studies is that in the

future will be able to avoid some of the mutations and antibiotic resistance that affected thepeople now.

MEDICAL UTILITY:

 

“TARGETING A CELL CICLE INHIBITOR PROMOTES BETA CELL REPLICATION.”

That studies allows us to expand the expectations of life of diabetic patients because from healthy donors and modification of the beta cells, people could restore their pancreatic function.

MEDICAL UTILITY

MEDICAL UTILITY

In the future scientists could detect the exact mechanism of the DNA breaks to avoid any type of mutation or disease that affect people and correct that before the birth.

BIBLIOGRAPHY

MARTINEZ S, Lina María; VARGAS G, Natalia; TORO M, Andrés Eduardo; PAMPLONA S, Ana Paulina, QUEVEDO O, Esteban. Biología Molecular. 5. ed. Medellín. Colombia. UPB, Facultad de medicina. 2012. pp 78-84. http://www.ecured.cu/index.php/C%C3%A9lulas_beta_del_p%C3%A1ncreas

http://medicalxpress.com/news/2014-01-cell-inhibitor-beta-replication.html

http://bionews-tx.com/news/2014/01/28/bcm-studies-mutagenesis-in-resting-e-coli-cells/