BACTERIAL PROTEIN ACETYLATION BACTERIAL PROTEIN ACETYLATION AND ADAPTATION VIA SYMBIOSISAND ADAPTATION VIA SYMBIOSIS

María Fernanda Marín BetancourtUPB Faculty of Medicine

3th semester 2010

FoldingFolding

FoldingFolding

IntroductionIntroduction

•The protein acetylation process is a control mechanism in eukaryotes.

•In bacterias this was specific to histones, the proteins which involves the DNA.

• The evolution process is the selective process in which nature selects the better organisms, but nature doesn’t say’s how.

Bacterial protein acetylation: Bacterial protein acetylation: the dawning of a new age.the dawning of a new age.

Bacterial protein acetylation: Bacterial protein acetylation: the dawning of a new age.the dawning of a new age.

The histone acetylation is the main acetylation reaction in bacterias.

Protein acetylation works like a control key in internal cellular control (in eukaryotes).

Bacterial protein acetylation: Bacterial protein acetylation: the dawning of a new age.the dawning of a new age.

Recently, researchers have found acetylated proteins in the mitochondrion of E.coli and S. enterica.

This discover make us think that bacterias could have any kind of cellular control mechanism mediated by protein acetylation.

Student opinionStudent opinion..

I think that the discover of this primary eukaryotic mechanism

in bacterias, gives to the researchers a new point of view about how the bacterias control their process, in contrast with

eukaryotic cells.

Adaptation via symbiosisAdaptation via symbiosis..

Adaptation via symbiosisAdaptation via symbiosis..

The fruit fly, is the example to show how this new symbiotic interaction works.

Adaptation via symbiosisAdaptation via symbiosis..

The fly enemy is a nematode that infects female flies when they are young, and make the flies sterile.

The bacteria called spiroplasma defends the bacteria from its enemy the nematode.

Adaptation via symbiosisAdaptation via symbiosis..

The bacteria, who benefits the fly, can be inherited to the offspring of the fly.

The symbiotic association between this two organisms shows that there’s no need to be the strongest organism, when you can have a friend to help you.

Student opinion.Student opinion.

I think this kind symbiotic relation between a bacteria and an organism would be an excellent way to protect us against diseases we cannot defend

ourselves but bacterias can.  

Medical UtilityMedical Utility

Bacterial protein acetylation: Bacterial protein acetylation: the dawning of a new age.the dawning of a new age.

This discovery could let us to create new antibiotics to control infections, by controlling the protein interaction with this mechanism (acetylation).

Bacterial protein acetylation: Bacterial protein acetylation: the dawning of a new age.the dawning of a new age.

This discovery will helps us to increase our knowledge about how bacterias control their process inside and the new role of protein acetylation in cellular signaling mechanism.

Adaptation via symbiosisAdaptation via symbiosis..

The possibility to inherit the microorganism could be an excellent way to prevent diseases in the future, our children could be more healthy.

Adaptation via symbiosisAdaptation via symbiosis..

This new kind of symbiotic relationship, could be very important to prevent o to treat diseases with the help of a tiny microorganisms like a bacteria.

BibliographyBibliography

John Jeanike, Robert Unckless, et al. Adaptation via Symbiosis: recent spread of a drosophila defensive symbiont. Science 9 July 2010: Vol. 329 nº 5988, pp. 212-215 DOI:10.1126/science. 1188235.

Hu Linda, Lima Bruno P, Wolfe Alan; Bacterial

protein acetylation: The dawning of a new age. Molecular Microbiology; (2010) 77(1), 15-22

Thanks