Clinical case study new rev03

Oragiene™ Clinical

Case Study

Technology co-developed by Malaysia, Sweden and Singapore

Clinical Case Study

Oragiene™

Diabetic Socks

MEDICAL GROUP

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If we can protect our loved ones, do not worry about bacterial infection, it would mean that a really good thing? But harmful bacteria is everywhere, so we must continue to clean and disinfect our environment to protect our loved ones! ? With so difficult, we already have solutions! ? See Oragiene technology products!

Founder of Oragiene™ And Oracle Medical Group Chairman Datuk Seri Paduka, Dr. Simon Goh Chew Kooi PhD S.P.M.P, D.K.M, P.J.K.. 拿督斯里巴杜卡吴秋葵博士

Welcome to Oragiene ™ family. We are proud to bring genesis revolutionary and environmentally friendly anti-bacterial technology and products to everyone. We, together with the world's outstanding doctors, scientists and professionals in cross-border cooperation in joint research and development of technology and products for human life to create a better life quality. I hope Oragiene ™ technology bring real benefits to protect our families, love, health and safety of their loved ones.

Oragiene Inside products come from the passion of distinguished doctors who merge the facts of medical history into cutting edge products for the benefit of the community. Through the vision of our founder Datuk Seri Paduka Dr. Simon Goh, the conscientious research and development and the passion of Dr. Patrick Tan, Dr. William Tan , Dr. Desmen Thang and Dr. Enrico Magosso to share the benefits of advanced silver technology with the community,

a harmony of science, medicine and lifestyle has been created.

Oragiene and Oracle Medical founder Datuk Seri Paduka Dr. Simon Goh (Left 2), the conscientious research and development of Dr. Patrick Tan (Left 1), Dr. Enrico Magosso (Centre) , Dr. William Tan (Right 2) and Dr. Desmen Thang (Right 1).

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Our Vision • To be a leading innovator of healthcare

products and solutions globally; • To improve the quality of life of patients

and the community.

Our Mission • To deliver practical and comprehensive

healthcare products and solutions; • To set the highest standards of service

excellence as a benchmark for the industry;

• To support and champion ecologically and environmentally friendly practices;

• To ensure that both employees and shareholders continue to experience an outstanding return on their investments through providing life-changing products to our customers

Oragiene founder Datuk Seri Paduka Dr. Simon

Goh (Centre), the R&D scientists,

Dr. William Tan (start from left)

Dr. Patrick Tan , Dr. Desmen Thang and

Dr. Enrico Magosso

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Oragiene Inside is committed to the highest standards of environmental responsibility by keeping abreast of advances in the management of the environment, our conduct and compliance with environmental legislation.

Our aim is always to manufacture products in a manner that both preserves and improves the sustainability of our environment.

“We ensure that economic development and

environmental protection are in harmony by avoiding

wasting non-renewable resources and to actively

recycle whenever possible. We also live by our belief of

communicating this environmental pursuit to

relevant contractors, suppliers and the

community.”

Oragiene Founder – Datuk Seri Paduka Dr. Simon Goh

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Silver has long been known to treat infections, purify water and keep food fresh. As far back as 460BC the father of modern medicine, Hippocrates used silver to heal wounds and treat ulcers. In the early 1700’s Angelus Sala used silver nitrate to treat chorea and syphilis.

During the Napoleonic Wars, the armies of Tsar Alexander used water containers lined with silver to clean drinking water. It’s a common fact that in the early 1900’s, American farmers would place silver coins in milk bottles to prolong the milk’s freshness. Even in World War I, before the advent of antibiotics, silver was used to prevent and treat infection.

Evidence Based Technology

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The simple answer is medical effort was placed on the new ‘wonder cures’ of antibiotics, but we now know that these can be ineffective when bacteria and microbes become resistant.

It’s also a case that ‘human conditioning’ in expecting a visit to the doctor will result in a prescription being filled in that creates a culture that a pill can cure anything.

It’s time to look to the history of medicine to show the way forward.

Oragiene Inside products are designed with an in-built antimicrobial technology that employs silver ions to inhibit the growth of micro organisms. This is possible through an innovative treatment process that bonds the silver compound into the Oragiene Inside material. Through co-development utilizing Swedish technology, Oragiene Inside has taken a step ahead in research and development and created practical solutions for the healthcare industry and the community. 7

Silver Ions breaking through the cell wall

Silver Ions disrupting the respiration of the microbe

Silver Ions attaching to the DNA of the microbe to stop cell replication

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Certificate No: 1013909.272/4600 (IMSL, UK)

Test institutes & standards • The Medical Institute of Microbiology, University of Milan, Italy • The Virology Institute, University of Catania, Italy • The Swedish Institute for Food and Biotechnology (SIK), Gothenburg, Sweden • LawLabs, Birmingham, United Kingdom • IMSL, Berkshire, United Kingdom • Institute of Microbiology and Epidemiology, Military Academy of Medical Science, Beijing, the People’s Republic of China

The following standards have been implemented during testing: • For hard surfaces: JIS 2801 • For textiles: AATCC-100

Tests certification include: • U.S. FDA (Food & Drug Administration) • U.S. EPA (Environmental Protection Agency) • E.U. BPD (Biocide Product Directive) • BgvV (Bundesinstitut für Gesundheitlichen Verbraucherschutz Und Veterinärmedizin) • EFSA (European Food Safety Authority) • Ö ko-Tex • Blue Sign

International Test

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International Test

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For Oragiene™ technology antimicrobial mechanism of catalytic metal ions and light. Oragiene™ silver determine its chemical structure has a high catalytic ability, high oxidation state of silver reduction potential high enough to produce atomic oxygen to the surrounding space. Atomic oxygen can be sterilized with strong oxidizing. According to the determination of water containing Ag + to 0.01mg / 1, the water can completely kill E. coli, can keep for up to 90 days does not propagate a new flora.

WWW.ORAGIENE-GLOBAL.COM HEALTHCARE

Diabetes It is interesting to reflect that in the first edition of the IDF Diabetes Atlas, released in 2000, the estimated global diabetes prevalence was 151 million. In this newest edition, the estimated diabetes prevalence for 2010 has risen to 285 million, representing 6.6% of the world’s adult population, with a prediction that by 2030 the number of people with diabetes will have risen to 438 million. IDF DIABETES ATLAS 2011

Diabetes is basically a metabolic dysfunction which makes people suffer from high glucose levels in blood either because insulin is not being produced in the pancreas in adequate amounts or the body somehow is unable to respond effectively to the insulin being produced in the pancreatic cells. Now there are two basic types of diabetes; Type 1 and type 2 Diabetes and to really help yourself in treating the type you are diagnosed with, it is vital to have a brief comparison of type 1 Vs type 2 Diabetes.


Diabetic Neuropathy

Neuropathy often occur in people who have diabetes due to poor blood circulation. Nerve damage (neuropathy) in the feet can result in a loss of foot sensation and changes in the sweat-producing glands, increasing the risk of being unaware of foot calluses or cracks, injury or risk of infection.

We recommend wearing it 24 hours a day. For diabetes patients with neuropathy condition (with or without insulin dependent), must wear at least 16 hours a day. ORAGIENE Diabetic Socks will release micro-magnetic field that can help blood circulation and efficacy of to killing germs up to 99.99%.

Diabetes Risk


Diabetic Ulcer

Diabetic foot ulcers are sores that occur on the feet of people with type 1 and type 2 diabetes. Up to 25% of people with diabetes develop foot problems. Diabetic foot ulcers usually occur on the bottom of the foot Symptoms

Sores, ulcers, or blisters on the foot or lower leg Pain Walking with difficulty Discoloration in feet: black, blue, or red Cold feet Swollen foot or ankle Fever, skin redness or swelling, or other signs of infection

We recommend wearing it 24 hours a day. For diabetes patients (with or without insulin dependent), must wear at least 16 hours a day. ORAGIENE Diabetic Socks will release micro-magnetic field that can help blood circulation and efficacy of to killing germs up to 99.99%.


Pilot Clinical Research Study

Clinical Trial Study Patient No: ORF/2011/DU/001 Age: 51 yrs old Race: Chinese Sex: Female Wagner Grading Scale: Grade III Condition: Diabetes Type II, Chronic Ulcers 3 yrs

* Strictly comply to doctor instruction for wound care and instruction for use of Oragiene Diabetic Socks

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Clinical Trial Study Patient No: ORF/2011/DU/004 Age: 66 yrs old Race: Malay Sex: Female Wagner Grading Scale: Grade III Condition: Diabetes Type II, Chronic Ulcers 1 yrs

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Clinical Trial Study Patient No: ORF/2011/DU/005 Age: 66 yrs old Race: Indian Sex: Female Wagner Grading Scale: Grade III Condition: Diabetes Type II, Chronic Ulcers 1 yrs

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Clinical Trial Study Patient No: ORF/2011/DU/012 Age: 56 yrs old Race: Indian Sex: Male Wagner Grading Scale: Grade IV Condition: Diabetes Type II, Chronic Ulcers 1 yrs

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Clinical Trial Study Patient No: ORF/2011/DU/013 Age: 56 yrs old Race: Indian Sex: Female Wagner Grading Scale: Grade IV Condition: Diabetes Type II, Chronic Ulcers 1 yrs

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Clinical Trial Study Patient No: ORF/2011/DU/014 Age: 62 yrs old Race: Indian Sex: Female Wagner Grading Scale: Grade II Condition: Diabetes Type II, Chronic Ulcers 1 yrs

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Clinical Trial Study Patient No: ORF/2011/DU/016 Age: 64 yrs old Race: Malay Sex: Female Wagner Grading Scale: Grade IV Condition: Diabetes Type II, Chronic Ulcers 2mths

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Healthy Lifestyle

Whether you have diabetes or not, you should eat healthily and exercise regularly. A healthy lifestyle can help prevent the onset of type 2 diabetes, and limit diabetes-related complications for those who already have the condition. Therefore, depending on your condition, a healthy lifestyle can be achieved by following the four point plan or the four point plan + medication (insulin, tablets, or both)

A balanced diet Physical exercise Correct medical attention A right foot-care

Balanced diet

A right foot-care

Physical Exercise

Correct Medical Attention


Instruction for Use CONSULT Consult with your podiatry or doctor for wound dressing procedures

DRESSING Daily wound cleaning and re-dressing as per podiatry or doctor medical adviced

Immediate WEAR Oragiene Diabetic Socks

within 5 minutes after wound dressing and the wearing time will be vary according to the wound size as per recommend guideline from Oragiene

ROUTINE CHECK-UP Maintain personal hygiene and on time routine check up and consultation with podiatry or doctor

Foot Care

1. Daily foot examination for skin break, minor infection and callus

2. Prevention of dry or cracked skin

3. Wear Oragiene Diabetic Socks for foot protection

5. Avoid walking barefoot outside and inside the house to protect feet

6. Trim toe nails straight across

4. Thoroughly inspect your feet daily and keep them clean and dry


Medical Advice

Hypoglycemia (Low Glucose Level) is the

clinical syndrome that results from low blood sugar level. The most common forms of hypoglycemia occur as a complication of treatment of diabetes mellitus with insulin or oral medications.


Without compression marks after whole day wearing.

Each pair of Oragiene™ Healthcare socks has full product liability insurance of One Million.

Natural cotton ball will appear after washing.

Please call us to verify the original product code & information.

Recognise the special Anti- imitation sticker on product box.

Cool, Highly Expandable, Soft and Friendly to your skin.

Take note on below ORAGIENE™ Diabetic Socks special anti-imitation design :

Anti-imitation Design & Caution

Hand wash | wash at 30 ° C (= 86 ° F) max | do not bleach | Use a mild detergent of your choice | Hang to dry indoors in normal room temperature | do not dry clean

Material: 100 % CMC4 Cotton

Special Recommendation: Buy shoe in the evening because feet tend to expand towards evening. Make sure they fit well.

Inappropriate footwear can lead to serious diabetic foot complaints such as ulcers and infections. It is vital to wear appropriate footwear.

Foot Wear

ORACLE INTEGRATED MEDICAL PROVIDER HOLDING SDN. BHD. (870435-K) 甲骨醫藥器材控股有限公司 Oragiene Biotech (s) Pte. Ltd. (Co. Reg. 201014978N) 甲骨医药企业有限公司 Eastlink Light Industrial Factory, 3018 Bedok Nth St 5 #02-34 Singapore 486132 Tel: +656-288 7628 Fax : +656-846 8920 Email: [email protected] Oragiene Marketing Sdn. Bhd. (880689-V) 甲骨医药企业有限公司 No. 1, Lorong Tembikai 6, Kawasan Perniagaan Sungai Rambai, 14000, Bukit Mertajam, Pulau Penang, Malaysia Tel: +604-538 6880 Fax: +604-538 0880 Email: [email protected]


Business & Technology Development by:

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