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brian m. bot | principal scientist |
2016 june 06
sage bionetworks
ohsu oncology retreat
mobile technologies:riding the hype cycle together
sage bionetworks
sage bionetworks
promote open systems, incentives, and norms to redefine how complex biological data is
gathered, shared, and used
our approach
sage bionetworks
engage diverse communities of researchersaround biological and analytical problems
too complex for a single institution
our focus
empower citizens to track their own healthand contribute deep phenotypic data to
research topics important to them
CRC Subtyping Consortium
DREAM ChallengesProgenitor Cell Biology Consortium
TCGA Pan-Cancer Consortium
CommonMind Consortium
PsychENCODE
Accelerating Medicines Partnership
Resilience Project
M2OVE-AD Consortium
Dengue FeverLINCS project
Oncology Molecular ClassifiersNext Gen Scientific Publishing
Mozilla Science Labs
sage bionetworks
public / private partnership between NIH, 10 biopharmaceutical companies
and several non-profit organizations
Accelerating Medicines Partnership
($ Millions) Total Project Total NIH Total
IndustryAlzheimer’s
Disease 129.5 67.6 61.9
Type 2 Diabetes 58.4 30.4 28
Rheumatoid Arthritis 41.6 20.9 20.7
TOTAL 229.5 118.9 110.6
Accelerating Medicines Partnership
Target Discovery
Target Discovery
Target Discovery
Target Discovery
Target Validation
Target Validation
Target Validation
Target Validation
Shared Information for
Target Identification
coordinate sharing of early-phasetarget identification insights
Accelerating Medicines Partnership
AMP-AD Collaborative
Workspace
Quarterly Depositions
Broad/RUSH
Mt. Sinai
U Fl/ISB/Mayo
Emory
Sage
Other Partners
Individual Partner Workspaces AMP-AD Data Portal
Consortium Space
Public space
AMP-AD Synapse Project Structure
Accelerating Medicines Partnership
CRC Subtyping Consortium
DREAM ChallengesProgenitor Cell Biology Consortium
TCGA Pan-Cancer Consortium
CommonMind Consortium
PsychENCODE
Accelerating Medicines Partnership
Resilience Project
Dengue FeverLINCS project
Oncology Molecular ClassifiersNext Gen Scientific Publishing
Mozilla Science Labs
sage bionetworks
M2OVE-AD Consortium
analysis of: 12 tumor types 6 molecular profiling platforms
TCGA Pan-Cancer Consortium
18NPG papers
68core projects248
researchers
28institutions
1070datasets1723
results
TCGA Pan-Cancer Consortium
TCGA Pan-Cancer Consortium
CRC Subtyping Consortium
DREAM ChallengesProgenitor Cell Biology Consortium
TCGA Pan-Cancer Consortium
CommonMind Consortium
PsychENCODE
Accelerating Medicines Partnership
Resilience Project
Dengue FeverLINCS project
Oncology Molecular ClassifiersNext Gen Scientific Publishing
Mozilla Science Labs
sage bionetworks
M2OVE-AD Consortium
CRC Subtyping Consortium
A
B
C
D
E
F
1
2
3
4
5
6
expert team data subtype
CRC Subtyping Consortium
A
B
C
D
E
F
1
2
3
4
5
6
...
expert team data subtype
CRC Subtyping Consortium
doi:10.1038/nm.3967 doi:10.7303/syn2623706
CRC Subtyping Consortium
sage bionetworks
engage diverse communities of researchersaround biological and analytical problems
too complex for a single institution
our focus
empower citizens to track their own healthand contribute deep phenotypic data to
research topics important to them
Healthmobile
Healthm
move beyond insular health tracking
move beyond insular health tracking
nearly 200 million smart phone users in US
>75%
how to balance desire to share w/ importance of privacy?
2013 september
2015 march
the hype cycle
the hype cyclelaunching
participant-centered consent
changeable by participant
~75k participants across all studies
>70% opted to share broadly
36
mPower
passive measures
gps - displacement
vectors
gps - displacement
vectors- -
structured activities
tapping activity
walking/standing activity
voice activity memory game
surveys MDS-UPDRS PDQ8
MDS-UPDRS PDQ8
MDS-UPDRS PDQ8
MDS-UPDRS PDQ8
four symptoms of PD
motor initiation gait/balance hypophonia memory
motor initiation gait/balance hypophonia memory
mPower activities
x
yz
userAcceleration
gravity
rotationRate
attitude
device motion readings at 100 hz
gait / balance
gait / balance
Monty Python's The Flying Circus
gait / balance
mPower six month data release
9,520 unique participants
8,320 completed at least one task
198,639 total activities and surveys completed
1,087 self reported parkinson diagnosis
mPower six month data release
task name type of task and schedule
unique participants unique tasks
demographics survey - once 6,805 6,805
MDS-UPDRS survey - monthly 2,024 2,305
PDQ8 survey - monthly 1,334 1,641
memory activity - t.i.d. 968 8,569
tapping activity - t.i.d. 8,003 78,887
voice activity - t.i.d. 5,826 65,022
walking activity - t.i.d. 3,101 35,410
mHealth research communityParkinson
mHealth research communityParkinson
Parkinson’s Disease Foundation Eli Lilly AstraZeneca Apple Verily Intel Infocepts Posit Science
MIT The Ohio State University University of Otago University of Texas Health Science Center Istanbul Sehir University University of Iowa University of Virginia University of Toronto Johns Hopkins University Vanderbilt University University of Rochester McGill University Xi'an Jiaotong University University of Washington Harvard University
mHealth research communityParkinson
leverage publicly available data
incorporate modules into phase I clinical trial w/ custom scheduling
initial training / testing done in person
follow ups done remotely by participants
mHealth research communityParkinson
mHealth research community
riding the hype cycle
together
brian m. bot———————— principal scientist community manager
[email protected] @BrianMBot
thank you
sage bionetworks
Parkinson mHealth research community
Parkinson mHealth research community
Parkinson mHealth research community
Parkinson mHealth research community
