GtoImmuPdb PortalAims● A unique access-point to immunological data in GtoPdb

● An expert-curated database containing immunological information

● Develop new pages and extend search mechanism for immunological data

● Assist in the identification of potential targets

● Assist in identifying experimental small-molecules for testing

S. D. Harding1, E. Faccenda1, S. Ireland1, A. J. Pawson1, J. L. Sharman1, C. Southan1, S. P. Alexander2, S. Anderton3, C. Bryant4, A. P. Davenport5, C. Doerig6, D. Fabbro7, F. Levi-Schaffer8, M. Spedding9, J. A. Davies1

1Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UNITED KINGDOM, 2Life Sciences, University of Nottingham, Nottingham, UNITED KINGDOM,3MRC Centre for Inflammation Research, QMRI, University of Edinburgh, Edinburgh, UNITED KINGDOM, 4Veterinary Medicine, University of Cambridge, Cambridge, UNITED KINGDOM,5Clinical Pharmacology Unit, University of Cambridge, Cambridge, UNITED KINGDOM, 6Department of Microbiology, Monash

University, Clayton, AUSTRALIA, 7PIQUR Therapeutics AG, Basel, SWITZERLAND, 8School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, ISRAEL, 9Spedding Research Solutions SARL, Le Vesinet, FRANCE.

IntroductionBackgroundImmune/inflammatory/infection responses and disorders are a major focus of pharmacological R&D. Chronic diseases, aspects of ageing and progress of infection all have, or depend strongly on, an immune, or inflammatory, component. Being able to modulate these more effectively with better drugs would be immensely valuable. Development of these drugs will benefit from improved data exchange between the immunology expert and pharmacology expert communities.

What is the Guide to IMMUNOPHARMACOLOGYOur Wellcome Trust-funded project to produce the IUPHAR Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb) addresses this need by providing a new portal to the existing IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb), that is both 'immunologist-friendly' for pharmacological information and 'pharmacologist-friendly' for accessing immunological agents and targets. GtoImmuPdb will be a freely-available, regularly updated and richly annotated resource. Curated by expert sub-committees at NC-IUPHAR, including those with expertise in immunity, inflammation and kinase biology.

GtoImmuPdb DataThe GtoP database will be enriched by tagging targets & ligands of immunological relevance and by linking these targets & ligands to immunological processes, cell types and relevant diseases.

Guide to PHARMACOLOGY URL: www.guidetopharmacology.org Public, beta-version of the Guide to IMMUNOPHARMACOLOGY is due for release in Spring 2017...

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an open access resource providing overviews of key properties, background reading and selective ligands of a wide range of biological targets.

The searchable database provides quantitative information on drug targets and the prescription medicines and experimental drugs that act on them. For ligands, data on approved status, clinical use and mechanism of action are included.

References1. Cell Ontology (OBO foundry), http://obofoundry.org/ontology/cl.html2. Gene Ontology Consortium, http://geneontology.org

Human targets in GtoPdb, 2016.4 release

Ligand classes in GtoPdb, 2016.4 release

The 2016.4 release (October 2016) of the database contains over 14,700 curated interactions across 2,794 human targets and 8,674 ligands. More specifically, the database contains 1,429 human targets that have quantitative interactions to a ligand.

Immuno Process and Cell Type DataGtoImmuPdb presents a set of top-level immunological process and cell type categories against which targets in the database can be annotated and which form the basis of organising, navigating and searching for immunological process and cell type associations.

Subsets of these ontologies are mapped to each top-level category. This then forms the basis of searches which will detect any cell type or process associations annotated with those terms (or their children).

Target detailed view pages display process and cell type associations

Including detailed curator comments and links to external references

As of 1 Dec 2016 the development GtoImmuPdb held 263 protein targets and 373 ligands tagged as being of immunological relevance.

GtoImmuPdb uses both Cell Ontology1 and Gene Ontology2 terms as controlled vocabularies against which to annotate. Displaying GtoImmuPdb data in detailed view of BTK

Immuno Cell Types

Pro-B-lymphocytes, B lymphocytes & Plasma cells

T lymphocytes (α-β type)

T lymphocytes (γ-δ type)

Natural killer cells

Polymorphonuclear leukocytes

Mononuclear leukocytes

Mast cells

Immuno Processes

Immune system development and differentiation

Proliferation and cell death

Production of signals and mediators

Regulation and responses to signals

Migration and chemotaxis

Cell-mediated immunity

Inflammation

Top-level categories for annotation in GtoImmuPdb

Targets Ligands

Cell types Processes

Disease

Target family pages use a toggle to switch between GtoPdb & GtoImmuPdb views

Ligand lists highlight immuno relevant ligands

with new icons. Here showing inhibitors

of BTK