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Deuterium content of water and glucose tolerance: potential role for the prevalence of affective disturbances

U1119

Affective disorders are a set of psychiatric diseases, also called mood disorders. The main types of affective disorders are depression, bipolar disorder, and anxiety disorder.1

Serotonin and Mood DisordersThe serotonin transporter (5HTT) is implicated in mood disorders and depression5HTT contains a gene-linked polymorphic region giving rise to a short and long alleleThe short allele results in lower transcriptional efficiency of the promoter

S allele

associated with anxiety-related traits and susceptibility for depressionCanli et al Nature Neuroscience 10, 1103 - 1109 (2007)

5HTT S allele and depression

Caspi et al Science 301 (5631): 386-389 (2003)

Generation of a model animal

The Nobel Committee for Physiology or Medicine Illustration: Annika Rh

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The SERT mouse (5HTT, Slc6a4)

Bengel et al Molecular Pharmacology vol. 53 no. 4 649-655 (1998)ES cellsMice

The SERT mouse (5HTT, Slc6a4)Murphy et al Nature Reviews Neuroscience 9, 85-96 (2008)

Depression rates and deuterium content of tap water

Upddated from Strekalova et al Behavioural Brain Research, 277: 237 244 (2015)

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Diabetes prevalence and deuterium content of tap water

Modified from Strekalova et al Behavioural Brain Research, 277: 237 244 (2015) withCDCs Division of Diabetes Translation, National Diabetes Surveillance System available at http://www.cdc.gov/diabetes/statistics

Diabetes prevalence vs. deuterium content in tap water (D/H)

Diabetes prevalences for every state across continental USA were obtained from Centers for Disease Control and Prevention. Prevalence of diabetes among US adults (18+) (Percentage), 2009. Suggested Citation: Division for Heart Disease and Stroke Prevention: Data Trends & Maps Web site. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA, 2010. Available at http://www.cdc.gov/dhdsp/http://apps.nccd.cdc.gov/NCVDSS_DTM/DetailedData.aspx?State=United+States&Category=6&Indicator=38&stratification=Total

Deuterium content in tap water for every state across continental USA were obtained from Strekalova et al, Behavioural Brain Res 2015, 277: 237-244 (Suppl data).

There is a significant linear correlation between prevalence of diabetes among adults = 18 years old and deuterium level in tap water across continental USA (Pearsons r=0.64, p