BRAIN HEALTH RETREATCASE WESTERN RESERVE

UNIVERSITY

George PerryAaron Sorensen

Hunting Valley, Ohio 28 January 2012

CASE FIRSTS Alzheimer/Parkinson connection Toxic/Diabetic neuropathy Cytoskeletal protein ultrastructural localization Ubiquitin AβPP 695/770 expression Fatal Familial Insomnia Vascular involvement Oxidative damage and response In situ hybridization for AβPP AβPP processing: Aβ40/42 Cell cycle reentry Mitochondria autophagy/fusion-fission Increased iron and copper link to oxidation Novel Prion diseases RNA as the major site of oxidative damage

ALZHEIMER DISEASE

2004 STUDY

CITATIONS 5th

PAPERS 2nd

CITES/PAPER 18th

Top 20 OverallRank Institution Total

Cites Number of Papers

Cites Per Paper

1 HARVARD UNIV 26351 578 45.59 2 DUKE UNIV 17640 345 51.13 3 MASSACHUSETTS GEN HOSP 14246 289 49.29 4 UNIV CALIF SAN DIEGO 11383 402 28.32 5 CASE WESTERN RESERVE UNIV 10666 453 23.55 6 UNIV WASHINGTON 9345 348 26.85 7 J OHNS HOPKINS UNIV 8607 260 33.1 8 UNIV TORONTO 8562 244 35.09 9 BRIGHAM & WOMENS HOSP 7923 115 68.9 10 UNIV CALIF LOS ANGELES 7847 280 28.03 11 WASHINGTON UNIV 7750 253 30.63 12 UNIV KENTUCKY 7715 270 28.57 13 UNIV SO CALIF 7585 251 30.22 14 VET ADM MED CTR 7504 183 41.01 15 VET AFFAIRS MED CTR 6423 194 33.11 16 COLUMBIA UNIV 6249 153 40.84 17 UNIV CALIF IRVINE 6120 184 33.26 18 ATHENA NEUROSCI INC 5990 49 122.24 19 UNIV S FLORIDA 5928 181 32.75 20 UNIV PENN 5876 269 21.84

2011 Citations 10th

Papers 20th

Cites/Paper 14th

Alzheimer Disease Top 20 Institutions - Citations

Rank Institution Citations Papers Cites/paper

1 Harvard Univ 84,312 1,700 49.60

2 MAYO CLIN & MAYO FDN* 44,471 1,096 40.58

3 Univ Calif San Diego 39,157 1,089 35.96

4 Johns Hopkins Univ 37,754 1,029 36.69

5 UNIV CALIF LOS ANGELES 36,940 1,086 34.01

6 Washington Univ 35,915 761 47.19

7 Univ Penn 34,865 1,055 33.05

8 Univ Washington 32,210 798 40.36

9 NIA 31,850 718 44.36

10 Case Western Reserve Univ 31,640 688 45.99

11 Univ Pittsburgh 28,606 853 33.54

12 Univ Calif San Francisco 28,504 850 33.53

13 Brigham & Womens Hosp 26,759 418 64.02

14 Univ Kentucky 26,504 737 35.96

15 Columbia Univ 26,404 798 33.09

16 UCL 26,326 910 28.93

17 Massachusetts Gen Hosp 25,913 579 44.75

18 Univ Cambridge 24,829 636 39.04

19 NEW YORK UNIV 23,789 694 34.28

20 Stanford Univ 23,470 454 51.70

MAYO CLIN & MAYO FDN*: these statistics include all three locations (Rochester, MN; Jacksonville, FL; and Scottsdale, AZ)

Alzheimer Disease Top 20 Institutions - Papers

Rank Institution Citations Papers Cites/paper

1 Harvard Univ 84,312 1,700 49.60

2 MAYO CLIN & MAYO FDN* 44,471 1,096 40.58

3 Univ Calif San Diego 39,157 1,089 35.96

4 UNIV CALIF LOS ANGELES 36,940 1,086 34.01

5 Univ Penn 34,865 1,055 33.05

6 Johns Hopkins Univ 37,754 1,029 36.69

7 UCL 26,326 910 28.93

8 Karolinska Inst 20,753 859 24.16

9 Univ Toronto 20,316 856 23.73

10 Univ Pittsburgh 28,606 853 33.54

11 KINGS COLL LONDON 19,056 852 22.37

12 Univ Calif San Francisco 28,504 850 33.53

13 Univ Washington 32,210 798 40.36

14 Columbia Univ 26,404 798 33.09

15 Washington Univ 35,915 761 47.19

16 Univ Kentucky 26,504 737 35.96

17 NIA 31,850 718 44.36

18 NEW YORK UNIV 23,789 694 34.28

19 Duke Univ 19,148 690 27.75

20 Case Western Reserve Univ 31,640 688 45.99

MAYO CLIN & MAYO FDN*: these statistics include all three locations (Rochester, MN; Jacksonville, FL; and Scottsdale, AZ)

Alzheimer Disease Top 20 Institutions – Citations Per Paper

(>=153 paper threshold)

Rank Institution Citations Papers Cites/paper

1 MIT 15,136 185 81.82

2 Baylor Coll Med 20,396 293 69.61

3 YESHIVA UNIV 19,406 299 64.90

4 Brigham & Womens Hosp 26,759 418 64.02

5 RIKEN 18,295 287 63.75

6 UT SOUTHWESTERN MED CTR 17,980 310 58.00

7 Max Planck Society 22,909 417 54.94

8 UNIV TEXAS SAN ANTONIO 15,325 294 52.13

9 CNRS 15,006 290 51.74

10 Stanford Univ 23,470 454 51.70

11 Harvard Univ 84,312 1,700 49.60

12 Univ Oxford 20,834 426 48.91

13 Washington Univ 35,915 761 47.19

14 Case Western Reserve Univ 31,640 688 45.99

15 Nathan S Kline Inst Psychiat Res 10,225 224 45.65

16 Massachusetts Gen Hosp 25,913 579 44.75

17 MRC 15,536 348 44.64

18 NIA 31,850 718 44.36

19 Univ Michigan 19,066 454 42.00

20 Cornell Univ 16,217 402 40.34

Looking at only the last year, Case is tied for 37th

Looking at the last three years, Case is 21st

CASE PEOPLE WHO LEFT Sami Harik Raj Kalaria Lucilo Autilio-Gabetti Andrea Leblanc Steven Younkin Todd Golde Chris Eckman Peter Whitehouse (changed fields) Karl Herrup George Perry Lawrence Sayre Vern Anderson Mark Smith

PARKINSON DISEASE

For PD, Case is not ranked high enough to generate a chart showing the other schools, and no one is ranked among the top 100

Last 20 Years

Last 10 Years

Last 5 Years

Last 3 Years

Last Year

Case PD rank (# of papers)

98 95 111 117 120

PRION

Looking at only the last year, Case would be tied for 32nd

Prion or AD or PD and FibrilIs this an emerging area for Case?

A. Focus of Top Programs in AD UCSD

UCSFMGHKarolinskaUCLAUCLMayo

B.Focus of Science and Nature papersC.Areas of greatest recent impact:

Imaging, MCI, biomarkers

Future Research Direction

Future Planning Goals1. Shared synergistic goals – to

develop/maintain novel areas2. Institutional support3. NIH and other major support - Alzheimer

or Udall Center4. Philanthropy5. Faculty development/retention6. Excellent clinical foundation