SMART IMAGING TECHNOLOGIES web-pathology.net

Why Human Brain Cannot Accurately Score

Her2 Breast Cancer Biomarker

Brightness induction

Brightness induction is the modulation of the perceived intensity of a region by the luminance of surrounding regions and reveals fundamental properties of neural organization in the visual system of human brain.

This cognitive phenomenon has been extensively studied by neuroscientists (Heinemann, 1972; Yund & Armington, 1975).

R: 132G: 132B: 132

Brightness of two areas from the image on the right is identical , however our brain perceives brightness as different.

Logvinenko, Brightness Illusion

Her2 Biomarker Scoring

Brightness induction may pay a role in the process of manual scoring of Her2 breast cancer biomarker by the human observer.Scoring involves cognitive perception of staining intensity which is expressed via brightness of image areas

Brightness Induction phenomenon may inhibit ability of human observer to accurately assess expression of Her2 biomarker in adjacent areas Stained Her2 biomarker pattern on the right may look consistent to human observer, even that it includes areas with different brightness

Help with Machine Learning

Using machine learning to assist human expert with scoring Her2 patterns may help eliminate cognitive bias.

Deep Learning Visual Recognition Application can learn levels of pattern expression and analyze them quickly and objectively across entire slide. It can highlight pattern differences for human expert and provide quantitative statistical results for whole slide