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Estimated global number of new cases and deaths of melanoma in 2012
Lian & Mihm. Skin cancer chapter; 2014 World Cancer Report. WHO 2014
5-hmC 5-mC Melanocyte Melanoma cell Keratinocyte
Active
TET25-hmC
MelanomaNormal Skin/NevusGenetic
Epigenetic
5-hmC
TET
-KG Succinate
CO2
Isocitrate
CO2
5-mC 5-hmC
Lian et al. (2012). Cell 150: 1137
Metastatic melanoma(18 of 18)
5-hmC
Nodal nevus(10 of 10)
5-hmC
A B
C
Suspicious for micrometastasis
Lee JJ et al. (2015) Modern Pathology [Epub ahead of print]: 6
[MART-1]
[MART-1]5-hmC
DIFDouble-label