Developing Human Organs: 3D Bioprinting Presents the Healthcare Sector with Revolutionary

Opportunities

March 2015

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Research PREVIEW for3D Bioprinting: Transforming the Future of the

Healthcare Sector

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Healthcare Sector—The Major Shifts/Transformations

Some of the major transformations or innovations in the

healthcare sector are developing from the

convergence of different

technologies. Such convergence is seen

to have a major impact in terms of

meeting the needs in the healthcare sector.

Technological advancements have revolutionized the

healthcare sector. Evolution of new technologies that are compact yet

powerful, inexpensive yet effective, has encouraged researchers to

develop novel technologies for various applications in the healthcare sector.

These advancements have helped the healthcare sector in meeting market

needs. Bioprinting can drive advancements in the healthcare field,

for example, by advancing tissue engineering and biomaterials (which

are used to print 3D objects).

Healthcare Sector

What are the Big Shifts in Healthcare Sector by 2020?

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4D Printing

Composite Manufacturing

Nonmanufacturing

3D Bioprinting

3D PrintingFor development of prosthetics, orthotics, surgical guides, other patient implants, dental implants/aligners

For developing and generating cells, tissues, human organs, biological structures

For the development of novel medical devices, such as, surgical instruments with increased precision for various procedures.

Composites manufacturing would be helpful in the development of novel products in pharmaceuticals sector, comprising different chemical combinations for medicines and therapy.

Integrated computational modeling and engineering

The use of manufacturing

technologies has increased in the

healthcare sector for developing

various applications.

Some of these technologies that

have been summarized

have given rise to a number of innovations in

different applications within the healthcare

sector.

What is the Role of Manufacturing Innovations in Healthcare?

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3D Bioprinting3D Bioprinting

3D printing is moving in diverse directions and will expand its horizons in the future. There has been an

expansion of application in areas such as medical/dental applications, customized consumer

products, and custom parts replacement.

3DBP hardware systems require specific features to ensure that the bioprinting is carried out accurately. One such feature is low-shear deposition mechanism, essential for maintaining the growth and function of living cells. The speed of the printing or fabrication must be fast enough such that the bio-printed tissue is not destroyed due to lack of oxygen and nutrients. Another factor for healthcare applications is that all components that are part of the process or come in contact with the printed tissues must be non-toxic and sterilized to prevent contamination.

Some of the prominent 3D printing technologies available in the market are Stereolithography (SLA), Fused Deposition Modeling (FDM), Selective Laser Sintering (SLS), Electron Beam Melting (EBM), Selective Laser Melting (SLM), Laminated Object Manufacturing (LOM). Methods used for 3D printing for bioprinting of cells or tissues include stereolithography, inkjet printing, and fused deposition modelling.

There is still a much larger scope for 3D printing in the medical field. Another area of expected growth in 3D printing is production of replacement parts. It has the potential to make different structures, perhaps even in creating replacements of organs for the human body.

This specialized application is known as 3DBP, and is an area of key development and growth. 3DBP technology is now being used to create cells and

more complex structures such as human tissue or scaffolds for bone tissue engineering. Bioprinting is a

combination of engineering with biology to create living human tissues that replicate native tissue, and

can achieve unique tissue-specific metabolic functions.

Companies, research institutes, and universities around the world are working on developing this novel technology that can transform the healthcare sector (i.e., tissue engineering or even biosensors) in the coming years. A number of funding options are available for the start-up companies in the 3DBP technology sector, which is seen as a major driving factor for companies to expand research in this sector.

How 3DBP can Change the Paradigm of the Healthcare Sector?

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The Full Analysis Features the Following Content

Content Slide No.

Executive Summary 4

Research Scope 5

Research methodology 6

Key Findings 7

Major Shifts in the Healthcare Sector 8

What are the Big Shifts in Healthcare Sector by 2020? 9

Medical Devices 10

Life sciences 13

Pharmaceuticals 14

Diagnostics 15

What is the of Manufacturing Innovations in Healthcare? 17

Role of 3D Bioprinting 18

How 3DBP can Change the Paradigm of the Healthcare Sector? 19

Is 3DBP Ready for Commercialization? 20

Content Slide No.

How will 3DBP evolve in the healthcare sector? 21

Move and Shakers in 3DBP 22

How will 3D Bioprinting transform the Healthcare Sector? 23

Significance of 3DBP for Soft Tissue Printing 24

Impact and Opportunity Landscape of 3DBP for Soft Tissue Printing 25

Significance of 3DBP for Hard Tissue Printing 26

Impact and Opportunity Landscape of 3DBP for hard Tissue Printing 27

Significance of 3DBP for Organ Printing 28

Impact and Opportunity Landscape of 3DBP for hard Tissue Printing 29

3D Bioprinting Enabling Transformation of Healthcare Sector

30

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The Full Analysis Features the Following Content (continued)

Content Slide No.

Evaluation Metrics to Assess the Degree of Transformation Introduced by 3DBP in Healthcare

31

Framework to Assess the Degree of Transformation Introduced by 3DBP in Healthcare

32

Innovation Landscapes and Best Practices 33

Innovators Profile 34

Printing of Complicated Organs, Exploring Newer Materials and Expanding Application Base Attracts Funding

35

Patent Trends- Increase in Patent Publishing 36

Region-wise Development Efforts & their Best Practices to Create & Capture Value

37

Content Slide No.

Strategic Perspectives 38

Strategic Insights 39

Key Patents 40

Frost & Sullivan Story 44

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Interested in Full Access? Connect With Us

Kayla Belcher Corporate Communications – North America

210.247.2450

kayla.belcher@frost.com

Research Authors

Jithendranath Rabindranath

Research Analyst Technical Insights

Peter AdrianIndustry PrincipalTechnical Insights

Kasthuri Jagadeesan

Program Manager

Technical Insights

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Global Perspective40+ Offices Monitoring for Opportunities and Challenges

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Industry ConvergenceComprehensive Industry Coverage Sparks Innovation Opportunities

Automotive&

Transportation

Aerospace & Defense Measurement &Instrumentation

Information &Communication Technologies

HealthcareEnvironment & BuildingTechnologies

Energy & PowerSystems

Chemicals, Materials& Food

Electronics &Security

Industrial Automation& Process Control

AutomotiveTransportation & Logistics

ConsumerTechnologies

Minerals & Mining