ZedScan – Revolutionising Women’s

Healthcare Diagnostics

Darren Neill, Sales Director

Current Colposcopy Methods

• The whole colposcopy procedure is subjective and is

based on the clinical impression of the appearance of

the cervix

• Differentiating between mild abnormalities that will

resolve and those that will develop into cancer is not

possible

• Visualisation is at the surface of the cervix

• The use of acetic acid to identify “aceto-white” regions

is pragmatic and not based on any understanding of the

disease

• Quality assurance is difficult

2December 2017 Commercial in Confidence

What is ZedScan?

3December 2017 Commercial in Confidence

EIS (Electrical Impedance Spectroscopy)

4December 2017 Commercial in Confidence

Basement

membraneStroma

Surface

epitheliumNormal CIN 1 CIN 2 CIN 3 Invasion

Intermediate

Superficial

Parabasal

Basal

0.4

mm

ZedScan is not impacted by HPV genotype

• Colposcopy depends on identifying areas of

aceto-white

• Aceto-white is more likely to be associated

with HPV16 than other hrHPV types1

• Colposcopy is less effective at detecting

CIN2+ caused by non-HPV16

• ZedScan does not depend on aceto-white

and detects all CIN2+ equally well

• Although HPV16 causes the most

aggressive disease, non-HPV16 types

account for a high proportion of HG CIN

(50% in this group) and are responsible for

up to 30% of cancers

December 175

1 Jeronimo et al 2007

Conclusions

• ZedScan greatly helps with improving

colposcopic performance by minimising

subjectivity

Over treatment

Biopsy rates

Follow-up appointments

• Could be used as a triage in primary care

alongside primary HPV testing

6December 2017 Commercial in Confidence