The Precision Medicine Revolution (Geoffrey Ginsburg)

Genomic and Precision Medicine: The Future is Now

Geoffrey S Ginsburg MD PhD

Professor of Medicine and Biomedical Engineering Center for Applied Genomics & Precision Medicine

Duke MEDx Duke University

October 19, 2015

@PersonalizedMed

APPLIED GENOMICS & PRECISION MEDICINE


Early Precision Medicine: “Factors of Risk”

Factors of Risk in the Development of

Coronary Heart Disease—Six-‐Year Follow-‐up

Experience

Kannel WB et al. November 1961

§ High blood pressure §  Increased cholesterol §  Smoking

§ Diabetes §  Family history

§ Male sex

Source: Kannel WB et al. Ann Intern Med 1961;55:33−50.


The Path to Better Health Care

HumanGenome Project

Precision Health

Realizing the Promise of Genomic Medicine

How to use genomic information about an individual to optimize their clinical care ?

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The Path to Better Health Care

HumanGenome Project

Precision Health

Realizing the Promise of Genomic Medicine

How to use genomic and other information about an individual to optimize their clinical care?

Sequencing

Learning Health Systems

mHealth and eHealth

Big Data & AnalyIcs

PaIent Engagement

Advanced Therapies & DiagnosIcs


Data Integration and Analytics Will Enable Precision Medicine

Exposure Data

Electronic Health

Records

DATA MART Omics, Imaging

Data

Social

Network Data

Sensor Data

Geo-spatial Data

Predictive Modeling Discovery Individual and Population

Management Tools


Challenges in Genomic and Precision Medicine Implementation

•  InsItuIonal, clinician, and paIent acceptance •  Access to experIse and tesIng •  EHR integraIon of genomic/mHealth

informaIon and clinical decision support •  Data liquidity, standards, and security •  Outcomes studies for evidence generaIon •  Reimbursement

Genet Med 2013; 15:258-‐67.

Health & Medicine

The Precision Medicine Revolution (Geoffrey Ginsburg)