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Richard Clement Nutrition www.web-outpatients.com

Resveratrol

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Richard Clement Nutrition www.web-outpatients.com

Cancer need to be prevented

Taking Resveratrol daily may be as smart as stopping smoking It could be considered malpractice not to discuss the benefit of Resveratrol with patients, the low cost, the absence of side-effects, the growing scientific evidence makes it one of my favorite recommendation.

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RESVERATROL: Antioxidant

Polygonum extract clearly has antioxidant effects. Antioxidant activity of extract from Polygonum cuspidatumHsu CY, Chan YP, Chang JBiol Res. 2007;40(1):13-21. Epub 2007 Jul 19

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RESVERATROL: Breast Cancer

Oncogene. 2012 Dec 3. doi: Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. Pandey PR, Xing F, Sharma S, Watabe M, Pai SK, Iiizumi-Gairani M, Fukuda K,

Hirota S, Mo YY, Watabe K. Source Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois

University School of Medicine, Springfield, IL, USA. Abstract Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic

pathway is known to cause tumor cell death by apoptosis. We have also shown that resveratrol was capable of blocking the lipogenic gene expression in CSCs and significantly suppressed their ability to generate DCIS in animals, which provides us with a strong rationale to use this agent for chemoprevention DCIS.Oncogene advance online publication, 3 December 2012; doi:10.1038/onc.2012.519.

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RESVERATROL: Anticancer

Polygonum cuspidatum, contains  piceatannol

a superior anticancer agent.

An effective sample preparation approach for

screening the anticancer compound piceatannol

using HPLC coupled with UV and fluorescence detection

Lin LL, Lien CY, Cheng YC, Ku KLChromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):175-82. Epub 2007 Mar

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RESVERATROL: Better Source Polyganum

Resveratrol is a new anticancer

composition which is less toxicity

and higher efficiency in Polygonum cuspidatum.

 Studies on active substance of anticancer effect in Polygonum cuspidatumFeng L, Zhang LF, Yan T, Jin J, Tao WY.The Biopharmaceutical Laboratory, School of Biotechnology, Yangtze University, Wuxi, China

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RESVERATROL; Cardioprotection

Trans-resveratrol supplementation

may be a potential alternative to conventional HRT for cardioprotection

and osteoporosis prevention and may

confer other potential health benefits in womenBenefits of resveratrol in women's health Bagchi D, Das DK, Tosaki A, Bagchi M, Kothari SC Drugs Exp Clin Res. 2001;27(5-6):233-48 

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RESVERATROL:Anti-osteosarcoma

Oncol Lett. 2012 Oct;4(4):837-839.

Epub 2012 Jul 25. Effects of resveratrol on vascular endothelial

growth factor expression in osteosarcoma cells and cell proliferation.

Liu Z, Li Y, Yang R. Source Department of Orthopedics, First Affiliated Hospital of

Xinxiang Medical University, Weihui, Henan 453100; Abstract resveratrol (Res) may exert an anti-osteosarcoma effect

by inhibiting VEGF expression in tumor cells.

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RESVERATROL:Anti-mesothelioma

Food Chem Toxicol. 2012 Nov 9;52C:61-68. doi: 10.1016/j.fct.2012.10.060. [Epub ahead of print] Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human

malignant mesothelioma MSTO-211H cells. Lee YJ, Lee YJ, Im JH, Won SY, Kim YB, Cho MK, Nam HS, Choi YJ, Lee SH. Source

Division of Molecular Cancer Research, Soonchunhyang Medical Research Institute, Soonchunhyang University, Cheonan 330-090, Republic of Korea; Soonchunhyang Environmental Health Center for Asbestos, Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea.

Abstract Dietary phytochemicals as adjuvants have been suggested to play important roles in

enhancing chemotherapeutic potential owing to multitargeted chemopreventive properties and lack of substantial toxicity.. The combined treatment of resveratrol and clofarabine produced a synergistic antiproliferative effect. Taken together, the data provide evidence that the synergistic antiproliferative effect of resveratrol and clofarabine is linked to the inhibition of Akt and Sp1 activities, and suggest that this combination may have therapeutic value in treatment of malignant mesothelioma.

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RESVERATROL:Protect Arteries

Acta Clin Croat. 2012 Jun;51(2):227-35. The protective effects of resveratrol on human coronary artery endothelial cell damage induced by

hydrogen peroxide in vitro. Sayin O, Arslan N, Guner G. Source Research Laboratory, School of Medicine, Dokuz Eylul University, Izmir, Turkey. Abstract

Oxidative stress is defined as imbalance between the production and destruction of reactive oxygen species. The aim of this study was to investigate whether resveratrol could protect human endothelial cells against hydrogen peroxide damage in vitro. In this in vitro study on human coronary endothelial cells, the effects of resveratrol on the glutathione content in human coronary endothelial cells in vitro were evaluated with high performance liquid chromatography. The effects of resveratrol on protein expression of the glutamate cysteine ligase, glutathione peroxidase and glutathione reductase enzymes were evaluated with the Western blot method. Resveratrol increased the reduced glutathione contents significantly (p < 0.05). Resveratrol increased protein expression of the glutamate cysteine ligase, glutathione peroxidase-1 and glutathione reductase enzymes (p < 0.05). All data supported each other and suggested that resveratrol had a protective effect against human coronary artery endothelial cell damage. It is thought that these results could pave the way to the new therapeutic approaches to protect against oxidative stress that develops in cardiovascular diseases.

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RESVERATROL: Atherosclerosis Prevention

Int J Cardiol. 2012 Oct 22. pii: S0167-5273(12)01133-3. doi: 10.1016/j.ijcard.2012.09.027. [Epub ahead of print]

Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium.

Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B, Davis JG, Baur JA, Smoliga JM.

Source Institute for Diabetes, Obesity, and Metabolism, Perelman School of

Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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RESVERATROL: Atherosclerosis Prevention

Int J Cardiol. 2012 Oct 22. pii: S0167-5273(12)01133-3. doi: 10.1016/j.ijcard.2012.09.027. [Epub ahead of print]

Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium.

Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B, Davis JG, Baur JA, Smoliga JM.

Source Institute for Diabetes, Obesity, and Metabolism, Perelman School of

Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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RESVERATROL: DNA repair

J Oncol. 2012;2012:370481. Epub 2012 Sep 10. DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents. Raffoul JJ, Heydari AR, Hillman GG. Source Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Abstract Epidemiological studies have demonstrated the cancer protective effects of dietary agents and

other natural compounds isolated from fruits, soybeans, and vegetables on neoplasia. Studies have also revealed the potential for these natural products to be combined with chemotherapy or radiotherapy for the more effective treatment of cancer. In this paper we discuss the potential for targeting the DNA base excision repair enzyme APE1/Ref-1 using dietary agents such as soy isoflavones, resveratrol, curcumin, and the vitamins ascorbate and α-tocopherol. We also discuss the potential role of soy isoflavones in sensitizing cancer cells to the effects of radiotherapy. A comprehensive review of the dual nature of APE1/Ref-1 in DNA repair and redox activation of cellular transcription factors, NF-κB and HIF-1α, is also discussed. Further research efforts dedicated to delineating the role of APE1/Ref-1 DNA repair versus redox activity in sensitizing cancer cells to conventional treatment are warranted.

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RESVERATROL: May prevent hepatic steatosis

Biotechnol Lett. 2012 Dec;34(12):2205-12. doi: 10.1007/s10529-012-1034-0. Epub 2012 Sep 1. Resveratrol prevents hepatic steatosis induced by hepatitis C virus core protein. Jiang L, Gu Y, Ye J, Liu F, Zhao Y, Wang C, Xu Y, Cao X, Zhang L, Dong W, Li F, Wang J,

Wang H, Li Q. Source State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth

Military Medical University, No.17, Changle West Road, Xi'an, 710032, Shaanxi, China. Abstract Hepatitis C virus (HCV) core protein plays an important role in the development of hepatic

steatosis in patients with chronic HCV infection. Treatment of C57BL/6 mice infected with HCV core recombinant adenoviruses with resveratrol significantly decreased hepatic triacylglycerols (TAG) while the serum TAG level was unaffected. RT-PCR and Western blotting showed that HCV core protein attenuated the expression of Sirt1 and PPAR-α, which would be reversed by resveratrol. This was also confirmed in primary mouse hepatic cells infected with HCV core protein expressing adenovirus. Thus, resveratrol may prevent against hepatic steatosis by blocking the inhibited expression of Sirt1 and PPAR-α induced by HCV core protein.

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Richard Clement Nutrition

www.web-outpatients.com1-877-438-3042305-594-2145Fax 305-594-2174Richard Clement NutritionSince 12 years Created by Richard Clement MDNo reported adverse events or side –effectsFDA regulated facilityOur products are covered by liability insurance

Resveratrol From 20 cents to 60 cents a day depending of intake.