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VIDA MEDIA DE LA PROTEINA RELACIONADA CON LA SECUENCIA DE AMINOÁCIDOS EN LA REGION N-TERMINAL DE LA PROTEINA RECIENTEMENTE SINTETIZADA
INHIBIDORES DE LA TRADUCCIONInhibitor Comments
Cloranfenicol Inhibe a la peptidiltransferasa bacteriana
Estreptomicina inhibits prokaryotic peptide chain initiation, also induces mRNA misreading
tertraciclinas inhibits prokaryotic aminoacyl-tRNA binding to the ribosome small subunit
Neomicina similar in activity to streptomycin
Eritromicina inhibits prokaryotic translocation through the ribosome large subunit
Acido fuscídico similar to erythromycin only by preventing EF-G from dissociating from the large subunit
Puromicinaresembles an aminoacyl-tRNA, interferes with
peptide transfer resulting in premature termination in both prokaryotes and eukaryotes
Toxina diftérica catalyzes ADP-ribosylation of and inactivation of eEF-2
CicloheximidaInhibe a la peptidiltransferasa de
eucariotesback to the top
MUTACION Y SUS CONSECUENCIAS
• ATGTGCAAAGTCCCGTCACCT
TACACGTTTCAGGGCAGTGGA
AUGUGCAAAGUCCCGUCACCU
Met -Cis -Lis- Val-Pro-Val
Ser-Pro
ORGANISMO Nombre Científico
Número de cromosomas
Tamaño del genoma Kb
Numero de genes
.Porción que
codifica
Bacteria Mycoplasma genitalium
1 580 483 88 %
Escherichia coli
1 4639 4377 88 %
Yeast Saccharomyces cerevisiae
16 12,069 6241 70 %
Worm Caenorhabditis elegans
6 97,100 19,820 27 %
Fly Drosophila melanogaster
4 180,000 13,601 20 %
Weed Arabidopsis thaliana
5 117,000 25,498 29 %
Mouse Mus musculus
20 3,059,000 ~30,000 < 3 %
Human Homo sapiens
23 3,286,000 ~30,000 < 3 %