A Professional Destination for Cognitive Training, Remediation and Rehabilitation

Laura Fay, CEO, HAPPYneuron, Inc.

Laura.fay@happy-neuron.com

+650-209-8304

HAPPYneuron PRO

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Scientific Brain Training Group Founding Product Team

Bernard Croisile, M.D. Neurology, Ph.D. Neuropsychology M.D. Neurology, Ph.D. Neuropsychology Neuropsychology Department Head, Lyon Hospital Over 70 published books & papers on memory and dementia topics

Franck Tarpin-Bernard, Ph.D. Computer Science : Human-Computer Interaction specialty Over 12 published papers on scientific interactive casual game topics

Michel Noir, Ph.D. Cognitive & Educational Sciences Over 10 published books on cognitive game topics

10 Year History 1998 Collaborative Research at University of Lyon, France 2000 Scientific Brain Training founded in Lyon, France 2002 First products introduced Global Footprint

Cognitive Interaction: Assessment – Training - Rehabilitation Markets: Consumer - Clinical – Corporate Languages: French - German – English – Japan – Korea – Dutch – Spanish

HAPPYneuron, Inc. is part of the Scientific Brain Training Group of companies

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Cognitive Interventions

Training Remediation & Rehabilitation

Product HAPPYneuronwww.happy-neuron.com

HAPPYneuron PRO www.happy-neuron-pro.com

Brain Healthy Impairments, Neurological Damage

Purpose Deferring declineStaying sharp

Disease Management, Chronic Care, Acute Care

Conditions Anti-AgingSports performanceOn-the-job performance

MCI, Depression, Behavior Disorders, PTSD, ADHD, Chemo Fog, TBI, Stroke, Alzheimer’s Disease

Treatment Self Directed Guided by Professional

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Coach recommends certain exercises for a thorough cross-training cognitive workout, according to the your performance and preference.

Performance analysis is done based on age, gender &

education level.

Normalized comparisonsare performed with others

in your demographic group.

VirtualCoach

consultation

Play what you like OR take the Coach’s advise

Scientific PerformanceAnalysis

Track your activity &performance over time

Coach provides tips for performance improvement and application to every day life.

Personalized Cognitive Cross Training

for Healthy Adultswww.happy-neuron.com

HAPPYneuron PROProfessional Cognitive Therapy Solutions

Cognitive Training/Rem/Rehab Programs

Neurologists Psychiatrists Geriatricians Speech Therapists Education Therapists Language Therapists Occupational Therapists Cognitive Psychologists Nurse Managers ……and growing

Professions administering cognitive therapies

Clinician Managed Manage Patient Accounts/Access Assign Programs / Modules/Exercises Patients Communication Continuous monitoring Adaptive therapies - Treatment can be

continually, progressively improved Personalized AND scalable

Guided Programs Evidence based Reliable & effective Large engaging game variety Validated by research & years of

successful use Additional Data Exports for

Researchers

Key Platform Features

Program Examples

Program Availability Conditions Treated Principal Designer

Rehabilitation Now TBI, Stroke, etc. Bernard Croisile M.D. (Neurology), Ph.D Neuropsychology Dept. ,Lyon Hospital, France

Schizophrenia Now Schizophrenia Pascal Vianin, Ph.D., Dept Psychiatry, Lausanne Hospital, Switzerland

Aging Well 2010 Aging Brain, MCI Bernard Croisile M.D. (Neurology), Ph.D Neuropsychology Dept, Lyon Hospital, France

Depression 2010 Depression, Mood Disorders

Roland Jouvent, Ph.D., Paris 6 University at La Pitié-Salpêtriére Hospital

Various …. In progress In progress

Programs

We welcome partnerships with researchers and clinicians in the creation and validation of

clinical cognitive therapy programs .

Developing a Condition Specific Program

Select CognitiveFunctions

to be stimulated

DefineGame

ParameterSets

DefineResults-Based

ProgressionRules

Condition SpecificCognitive Program

Research ValidationEvidence based Intervention

Condition SpecificCognitive ProgramCondition SpecificCognitive Program

Clinician / Specialist / Researcher

The need for effective cognitive remediation is great Schizophrenia is a chronic and profoundly disabling

psychiatric disorder. 70–80% of patients with schizophrenia are

unemployed at any one time deficits in neurocognition are linked to social disability as many as 70% of patients with schizophrenia exhibit

neurocognitive deficits on measures of attention, learning and memory, problem-solving, language and/or sensory-motor skill

Cognitive Remediation In Schizophrenia

Schizophrenia Program Development

Training Modules(18 games)

Verbal MemoryVisual Spatial

Working MemorySelective Attention

Reasoning

10 levels, each consisting of

specific parameters

Start at level 1,Each game @ 100% accuracy

advances to next level

Dr. PascalVianin,

LausanneSwitzerland

Schizophrenia Program

Dr. Pascal VianinLausanne Hospital, Switzerland

28 subjectsComparison with RehaCom

Showed significant improvementPublication pending

-------------------------------------------------Dr. Nicolas Franck

Institute for Cognitive ScienceLyon, France

280 subjects, multi-site, 3-yrComparison with CRT

Positive preliminary results-------------------------------------------------

US based multi-site, drug-combo study starts in Spring 2010

Remediation for SchizophreniaPatient View

Remediation for SchizophreniaClinical & (optional) Patient View

An open tool with extensive customizability by the clinician Suitable for cognitive stimulation of TBI, Stroke and other patient-unique

impairments Task rich: 27 exercises, 9 modules, hundreds of unique combinations Precise customization to patient's specific needs Clinician control difficulty levels, pacing and goal setting

Rehabilitation Program

For all exercise, multiple levels of data analysis available Activity level Total time spent Progress over time / play Accuracy Reaction / Processing Speed Game Parameters Trend Analysis

Rehabilitation Program

Benefits

Engaging & Novel At home

participation Supervised Patient satisfaction

Customize Monitor Coach Evidence

Based Distance

therapy

Standardsof care Reduced cost of delivery

Highcontrol Measurementprecision

Each Program costs $50 per month includes 10 active accounts

Additional account packs can be added for $40 per month.

30 day FREE trial

Pricing for practitioners

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Independent Research

Geriatrics, Psychiatry, Neurology, Occupational Rehab, ADHD

Boston University, MA Columbia University, NY Hartford Hospital (Institute of the Living), CT Johnny Orr Memory Center, IA Queens University, Toronto, Canada UCLA, CA Veteran’s Administration, PA

Lausanne Hospital, Switzerland Lyon Hospital, France Pierre & Marie Curie Hospital, Paris France St. Anne Hospital, Paris, France University at La Pitié-Salpêtrière Hospital, Paris, France

Independent Research partners

Endorsements

“The advantage of the HAPPYneuron PRO platform is that it allows individuals to receive a more consistent dose of cognitive enhancement, thereby enabling the flexibility to design innovative research studies not previously possible.”

Christopher R. Bowie, PhD, Dept Psychiatry & Psychology, Queen’s University, Ontario, Canada.

"The HAPPYneuron PRO platform delivers engaging cognitive skills training programs. Our patients are motivated to work on these web-based exercises

because of the appeal of the exercises themselves, and because they are able to track their own progress and performance.“ Enid Gertmenian, LMSW, Lieber

Recovery and Rehabilitation Clinic, New York City.

"The program for schizophrenia offered at www.happy-neuron-pro.com is the best material I have ever seen for cognitive remediation for my patients."

Torben Christensen, Ph.D., Clinical psychologist. Aarhus University Hospital, Risskov, Denmark

Thank You

Laura FayHAPPYneuron, Inc.Laura.fay@happy-neuron.com+650-209-8304