Presentation of Can

Centrum für Angewandte Nanotechnologie (CAN) GmbH 1

• CAN GmbH – Center for Applied Nanotechnology GmbH

• Concepts from Science to Industry

• Dr. Frank Schröder-Oeynhausen

Center for Applied Nanotechnology (CAN) GmbH 2

Nanotechnology

in Germany

http://de.wikipedia.org/w/index.php?title=Datei:Coat_of_arms_of_Hamburg.svg&filetimestamp=20060301195030

Borstel:

Nanobiomedicine

Lübeck: UKSH

Lasercenter,

Nanobiomedicine

GKSS:

Membranes,

Nanomaterials TUHH:

Nanomaterials for

Transport Systems,

CNTs, Polymers, Fuel

Cell Systems

DESY:

Characterisation,

Dynamics on the

nanometer scale

EMBL:

Nanobiochemistry of

proteins

UKE, HPI:

Nanobiomedicine,

Molecular Imaging

BNI:

Nanobiomedicine

University HH:

Nanoparticle synthesis,

Nanomaterials,

Nanobiochemistry,

Energy Research,

Catalysis,

Nanostructures,

Nanoanalytics,

Nanodevices,

Theory of Nanosystems

huge

Medium

small

Activity:

CAN GmbH

Nanotechnology

in Hamburg

Center for Applied Nanotechnology (CAN) GmbH

Optically transparent

size 102

100

10-2

10-4

10-6

10-8

1 nm 1µm 1mm 1m

Surface to volume ratio

Nanotechnology

Properties



Our main expertise is on the production and

functionalization of nanoparticulate and nanocomposite

materials, encapsulation of active ingredients as well as

development of nanoparticle-based biological and

medical markers for the cosmetics-, consumables- and

pharma industry.

We produce nanoparticles of highest quality, offers

contract research and development services in the area of

nanotechnology and participates in national and

international research programs.

Mission: We offer nanoparticles for your purpose!

5 nm

Company Profile

Mission


Academia CAN GmbH Market

Science

Publications

Patents

Project Management

Standardization

Prototyping

Benchmarking

Products

Company Profile

General Conditions

Collaborative

Research

Own

Products

Contract

Research


Business Model: Public Private Partnership (PPP)

Founded: November 2005

Location: Hamburg

Staff: 25 + 6 (today)

Sales: 1.318.000 € (2009)

Partners: Verein zur Förderung der Nanotechnologie e.V. (65,2 %)

Free and Hanseatic City of Hamburg (24,8 %)

University Hamburg (10 %)

Subsidiaries: Screening Port Hamburg GmbH. (80,2 %)

Head of Supervisory Board: Prof. Dr. Klaus-Peter Wittern

Chief Scientific Officer: Prof. Dr. Horst Weller

Chief Operation Officer: Dr. Frank Schröder-Oeynhausen

Company Profile

Concept


Fields of Business Transfer Model:

• I. Cosmetics / Flavours: Contract Research

Thickener, Emulsions, Encapsulation

• II. Medicine / Medical Technology:

Nanoparticles for Diagnostics Own Products

Drug Delivery Systems International Collaboration

Analytics / Toxicity Service Tox-Tests

Analyses of Nanostructures Service Analytics

Assay Development

• III. Technical Applications:

Security Labels Contract Research (conf.)

Nanostructured Functionalized Layers National Collaboration

Business Segments


Nanoparticles

• Synthesis of ZnO - and TiO2 - nanoparticles

• Modification of nanoparticles

Polymers

• Thickener für water- and oilbased systems

• Systems for hair-repair

• Emulsions

• Mucoadhesive polymers

Encapsulation

• Encapsulation of drugs and flavours

• Water/Oil - nanoemulsions

Contact:

Personal Care: Dr. Marcel Ruppert ([email protected])

Hair Care: Dr. Marc Thiry ([email protected])

Contract

Research

Business Segment I: Cosmetics

5 nm

Ligands define stability and chemistry:

• Biocompatibility

• Coupling mechanisms

Core defines properties

depending on size:

• Colour

• Magnetism

• Conductivity

• Thermodynamics 5 nm

Nanoparticles: Properties


Business Segment II: Medicine

• Fluorescent Nanoparticles

• Emission max: 500 to 620 nm

• High reproducible properties

• Soluble in water or non-polar organic

solvents

• High physical and chemical stability

12


Features

Structure

• CdSe/CdS/ZnS dots

• Core-shell-shell structure

• Scalable core size

• Core and core-shell particles available, too

Own

Product


Nanoparticles: CANdot® Series A

18 Center for Applied Nanotechnology (CAN) GmbH

• Magnetic nanoparticles

• Diameter between 5 and 30 nm

• Small size distribution

• Soluble in water or non-polar, organic

solvents

• FeOX nanoparticles

• Hydrophobic acids for organic solvents

• Hydrophilic polymers for water

• Doping possible

magnet

Own

Product

Features

Structure


Nanoparticles: CANdot® Series M

A) Vapour Deposition (PVD / CVD)

B) Sol-Gel Technique

C) Wet-Chemistry


“Hot Injection Process”

Advantages

• universal applicable

• well known

• broad temperature range

Disadvantages

• temperature profile hard to

control

• slow mixing after injection

• “up-scaling” difficult

Nanoparticles: Synthesis



“Flow Synthesis”



A) Vapour Deposition (PVD / CVD)

B) Sol-Gel Technique

C) Wet-Chemistry




Nanoparticles: Properties



5 nm

Service

Analytics


Toxicity of Nanoparticles


size

shape

shells

ligands

quality

skin

lung

intestine

ICC

nanoparticle modification interaction

20

Example for studying the interaction between nanoparticles and cell system

• Red: Epithelial-cells (lung), stained with Draq5 (nucleus)

• Blue: CdSe-CdS nanoparticles with different blockcopolymer-labels, located in the cell cytosol and the cell membrane

Contact:

Toxicity: Dr. Thomas Frahm ([email protected])

Toxicity of Nanoparticles


Service


• The goal of VIBRANT is the development of nano-

technology-based systems for diabetes diagnosis

and/or therapy. from the pharmaceutical industry.

• CAN and UHH will provide a contrast agent

providing a stable and high signal intensity, which is

highly specific to the cell type, but low toxicity,

EU project VIBRANT

Ihr Ansprechpartner:

Dr. Theo Schotten ([email protected])

http://www.fp7-vibrant.eu/ Ultimately, VIBRANT will deliver β-

cell specific, functionally optimized

nanoconstructs and defined know-how

for in vivo applications in non-human

primates and humans with regard to

quantification of BCM, imaging of

http://www.fp7-vibrant.eu/




http://cordis.europa.eu/fp7/home_en.html

Centrum für Angewandte Nanotechnologie GmbH

Biocompatible Shell

~ 20 - 300 nm

Quantum Dots

Superparamagnetic particle

Ligand

Anchor/Linker

Micelle or Vesicle

The Nanocontainer Specific coupling agent

• EU Framework 7 Large Scale Project

• Idea and coordination: CAN GmbH

• Duration: 7/2009 to 6/2013

• Grant: 8 Mio EUR

• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark, Sweden and Germany

• Industrial Advisory Board: big pharma.

Outline

Ihr Ansprechpartner:

Dr. Theo Schotten ([email protected])


International

collaboration






The “Axis of Excellence”*

*) R = 0.989! ;-)

International

collaboration


25

CANdots® Series X as Security Labels:

• Activation of the host lattice by doping with rare-earth elements

• Reproducible Shape of Particles (spheres to ellipsoids, synthesis specific)

• Reproducible Size of Particles (7 to 40 nm, material- and synthesis specific)

• Physical und Chemical Stability (photo stabilized, inert to high temperatures, acids, bases und

organic solvents)

Contact:

Polymers: Dr. Jan Niehaus ([email protected])


Security Labels

Business Segment III: Technical Applications

Contract

Research

(conf.)

Quantum Dot-

Carbon Nanotube

Composites

B.Hernandez-Juárez, C. Klinke, A.Kornowski, H. Weller

Institute of Physical Chemistry. Universität Hamburg.


New Concept of a Solar Cell



New Concept of a Solar Cell


+ -

CB

VB

e

e

e

e

e

h

e

conductive polymer

h+

e-

e.g. Photovoltaics Collaboration

with Academia


Example: VIBRANT, EU-Project

• EU Framework 7 – NMP – Large Scale Project

Nanosciences, Nanotechnologies, Materials and New

Production Technologies

• Goal of the project: Development of marker systems for diabetes diagnostics

• Coordination: CAN GmbH

• Timeframe: 7/2009 to 6/2013

• Budget: about 8 Mio EUR

• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark,

Sweden and Germany)

• Industrial Advisory Board

• Internet: www.fp7-vibrant.eu

• Coordination of the application process (two step process)

Collaborative Research Projects

Business Model:




Intellectual Property Rights owned by CAN

1. Method for producing alkaline earth sulfate nanoparticles (Basolute I)

2. Process for preparing dispersible sulfate nanoparticles (Basolute II)

3. Luminescent core/shell nanoparticles

4. Core/shell nanoparticles suitable for (F)RET-assays

5. Synthesis of nanoparticles comprising metal(III)vanadate

6. Security printing liquid and method using nanoparticles

7. Paramagnetic nanoparticles

8. Synthesis of nanoparticles (Dotnan)

9. X-Ray opaque dental nanomaterials

10. Postsynthetic polyacid/base modification of nanoparticles

11. InP nanoparticles and method for their manufacture

12. Reactor for the synthesis of nanoparticles

13. …


Patents, Products

Business Model:

CANdots Series A

CANdots Series X


First Contact

• Discussion on ideas / problems / requests

• Non Disclosure Agreement (NDA)

Concept

Agreement on:

• R&D goals

• Timeframe

• Budget

• Patent- and License issues

• Other partners

• Legal issues

Contracts

• Small jobs (< 10 T€)

• Feasibility Studies (< 50 T€)

• R&D Contracts (> 50 T€)

Contract Research

Business Model:

Consulting and Service

• Studies

• Surveys

CAN-Analytics

• Scanning Electron Microscopy (SEM / TEM)

• Static and Dynamic Light Scattering (SLS / DLS)

• X-Rax Scattering (SAXS / WAXS)

• Atomic Force Microscopy (AFM)

• Infrared Spectroscopy

• Mass-Spectrometry (MS, MALDI-MS)

• Absorption Spectroscopy (UV-Vis, NIR)

• Fluorescence Optical Microscopy

• Confocal Laser-Scanning Microscopy

• Electron Spin Resonance-Spectroscopy

• SQUID Magnetometry

• Chromatography

• Rheology


Service

Business Model:

University of Hamburg

Cooperation Contracts

Companies:

Beiersdorf AG www.beiersdorf.com

Eppendorf AG www.eppendorf.com

BODE Chemie GmbH www.bode-chemie.de

Merck KGaA www.merck.de

Bayer AG www.bayer.de

Institutions:

Free and Hansestadt Hamburg http://fhh.hamburg.de/

Hamburger Sparkasse www.haspa.de

Hamburg Chamber of Commerce www.hk24.de

Innovationsstiftung Hamburg www.innovationsstiftung.de

Life Science Agentur Norgenta www.norgenta.de

Center of Competence Hansenanotec www.nanoscience.de/hansenanotec/


Partner

CAN GmbH:

http://www.beiersdorf.com/

http://www.eppendorf.com/

http://www.bode-chemie.de/



http://www.merck.de/

http://www.bayer.de/

http://fhh.hamburg.de/

http://www.haspa.de/

http://www.hk24.de/

http://www.innovationsstiftung.de/

http://www.norgenta.de/

http://www.nanoscience.de/hansenanotec/


www.can-hamburg.de


Grindelallee 117

20146 Hamburg

Germany

T +49 40 42838 – 4983

F +49 40 42838 – 5797

E [email protected]

… get in contact !

CAN GmbH:

Health & Medicine

Presentation of Can