Cytological features of malignancy Lesion : Remarkable variation in cell size and shape (Cellular polymorphism )and nuclear size and shape (nuclear polymorphism )

mitotic figures (M) and nuclear hyperchromatism .

• Cytological features of malignancy• Necrosis (N) of the tumor related to ischaemia.

• Organ: myometrium• Lesion: benign neoplasm of the uterine smooth

muscle (L) surrounded by normal myometrium.• Diagnosis: Leiomyoma .

• Organ: myometrium ( higher magnification)• Lesion: tumor margin well circumscribed and no

evidence of local invasion and their is pseudocapsule (C).

• organ: Breast• Lesion: the neoplasm has an irregular outline and the

neoplastic cells invading the fatty tissue and collagenous stroma of the breast.

• Diagnosis: malignant neoplasm of Breast.

• organ: Breast ( higher magnification)• Lesion: hyperchromatic malignant cells can be

seen infiltrating the surrounding adipose tissue.• Diagnosis: malignant neoplasm of Breast.

• Lesion: the cells are commonly arranged in broad sheets and large nests (N) , formation of keratin* known as dyskeratosis (D), and forms lamellated pink-stained masses known as keratin pearls (KP).

• Squamous cell Carcinoma.

• Organ: Colon

• Lesion: mitosis are seen and nuclear hyperchromatism

and higher nuclear to cytoplasmic ratio.• Diagnosis: Adenocarcinoma ( well Differentiated )

• Organ: Connective tissue• Lesion: Consist of various combination of spindle cells

(S) ,cells resembling histiocytes (H) with pale foamy cytoplasm and malignant giant cells (G) mitotic figures are plentiful.

• Diagnosis: Malignant Fibrous Histiocytoma.

Pathology: the Hidden Science that Saves Pathology: the Hidden Science that Saves LivesLives

Pathology: is the Science behind the CurePathology: is the Science behind the Cure

This pathology lab is prepared by, Dr. Omar Emad This pathology lab is prepared by, Dr. Omar Emad Ibrahim , Pathology Dep. Faculty of Medicine & Ibrahim , Pathology Dep. Faculty of Medicine &

Health Sciences, Thamar UniversityHealth Sciences, Thamar University . . The images is taken fromThe images is taken from

Atlas of Basic Histopathology.