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alopecia areata
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Alopecia Areata
Nargess Tavakoli
Guilan university of medical sciences
• A nonscarring type of alopecia
• Many different patterns
• The true cause ?
HistoryAcute onset
can affect any hair-bearing area
scalp
Sigle/multiple
Itch?
Physical Exam
• Alopecia pattern in AA?
• Other findings?
Pattern of alopecia
• Patchy• Ophiasis• sisaipho (ophiasis spelled
backwards) • diffuse
Ophiasis
Alopecia Totalis
AT
Alopecia universalis
complete loss of hair on all hair-bearing areas
Rare
Nail involvement
• Pitting
• Several other abnormalities have been reported
Epidemiology• Prevalence: 0.1-0.2% in the
general population• Sex: F = M• Age: can occur at any age / more
common before 40yo,esp. childhood & adolescence
physiopathology
• AA progresses as a wave of follicles which enter telogen prematurely
• Autoimmune/T_cell mediated/genetic
Etiology
• The true cause: unknown
• autoimmune?• Genetic?• Infection?• Emotional stress?
Evidence supports the autoimmune hypothesis
• Other autoimmune disease
• Changes in Immune system
(cellular/homoral) • Experiments on mice
Genetic
• Familial? 4_27%• AD?• HLA• Atopia• Down’s synd.
•Infection? CMV?
•Emotional stress?
Diagnosis•Clinicaly•Biopsy?•Thyroid tests?
ChronicRegrowth(+/- therapy) usuallyHow much does it take?
Recurrence may occur
Prognosis
White hair regrowth in alopecia areata.
Adverse prognosis factors
onset at a young age severe forms + FH of AAnail dystrophy Ophiasis
Treatment
Treatment
• No medication?• Local steroidsatrophy• Antralen• Systemic steroids• Irritant dermatitis• False hair to cover?