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Treatment and
ProphylaxisNur Amalina bt. Aminuddin Baki
60
Objectives
• Treatment: – Supportives measures– Drugs
• Prophylaxis:– Chemoprophylaxis– immunoprophylaxis
Introduction
Bacterial Meningitis• More severe• Requires treatment• Available vaccine present
Viral Meningitis• Less severe• Supportives measures• Self -limited
Recommended Empiric Antibiotics for Suspected Bacterial Meningitis
Age or Predisposing Feature AntibioticsAge 0-4 wk Ampicillin plus either cefotaxime or an
aminoglycosideAge 1 mo-50 y Vancomycin plus cefotaxime or ceftriaxone
Age >50 y Vancomycin plus ampicillin plus ceftriaxone or cefotaxime plus vancomycin
Impaired cellular immunity Vancomycin plus ampicillin plus either cefepime or meropenem
Recurrent meningitis Vancomycin plus cefotaxime or ceftriaxone
Basilar skull fracture Vancomycin plus cefotaxime or ceftriaxone
Head trauma, neurosurgery, or CSF shunt Vancomycin plus ceftazidime, cefepime, or meropenem
Bacterial Meningitis
• Neisseria meningitidis
• B,C,Y serogroup = developed region• A, w-135 serogroup = less developed region
Treatment Prevention
•Penicillin /chloramphenicol•Ciprofloxacin / Rifampicin for close contacts•Meningococcal vaccine
Meningococcal Vaccine • Quadrivalent (A,C , W-
135, Y)– MCV-4 (9m-55y)
– MPSV-4• Elderly (>55 years old)• Last for 3 year
• Bivalent (C,Y): – infant >6w – to prevent meningitis
C ,Y and HiB disease
• Serogroup A: MenAfriVac
• Serogroup B : difficult as too similar to neural antigen
•11-18y •HIV adolescent •>16y•Two doses
1: 11-12y2: 16y
•Three doses2 doses 2 months apart at 11-12yBooster : 16y
•X booster dose
• Haemophilus influenzae
Treatment Prevention
•ceftriaxone or cefotaxime•Ampicillin,
•Rifampicin X 4 days for close contact•Hib PRP vaccine
HiB PolyribosylRibitolPhosphate Vaccine
• Polysaccharide: limited usefulness• Conjugate:– Tetanus toxoid, diphteria toxoid, N. meningitidis
OMP– >2 months ( 2 doses at 2 month interval)
• Combination – Hib + DPT in USA
• Streptococcus pneumoniae
Treatment Prevention
•Penicillin• ceftriaxone / cefotaxime•Vancomycin
•PPSV23•PCV13•PCV7
Pneumococcal Vaccine• Polysaccharide : PPSV23
For increased risk groupoDysfunctional spleen,
nephrotic synd., sickle cell anemia, multiple myeloma, DM, immunodeficiency patient.
Single dose injection , last 5 years
(-): <2 years old, not lifelong
• Conjugated:PCV13 children at 2, 4,
6, and 12–15 months oldPCV7 bind to diphteria
toxoido 2-23monthso Increased risk in 2-5 years
old
• Mycobacterium tuberculosis
Isoniazid• Only in risk groups( 5mg/kg daily X 6-12M)
Unavoidable contact with patient with open TB Children which is tuberculin +ve but radiology clear adult with radiological evidence of inactive disease
Treatment Prevention•Isoniazid (H),rifampin (R), pyrazinamide (Z) , ,streptomycin(E)
•Isoniazid•BCG vaccination
Bacille Calmette Guerin Vaccine
• Strain of M bovis weakened by 239 serial subculture in glycerine- bile- potato medium (13 ears)
• 0.1ml ID small nodule (2-3w)• Given soon after birth • Complications :
Local : abscess, keloid formationRegional: lymphadenitisGeneral: fever , erythema nodosum
• Escherichia coli and group B streptococci
• Listeria monocytogenes
Treatment Prevention
•Gentamicin + cefotaxime or ceftriaxone (or chloramphenicol)
•No vaccines available
Treatment Prevention
Penicillin or ampicillin + gentamicin No vaccines available
Viral Meningitis
• Self-limited, offer supportive measureso Herpes simplex virusoMumpso Lymphocytic choriomeningitiso Enteroviruses including coxsackievirus, echovirus
and poliovirusPicornaviruses o Japanese encephalitiso HIV
• Complete recovery
Fungal Meningitis
• Cryptococcus neoformans
• Coccidioides immitis
Treatment Prevention
•Amphotericin B and flucytosine
•No vaccines available
Treatment Prevention•amphotericin B, fluconazole or miconazole
•No vaccines available
Protozoal Meningitis
Treatment•not fully satisfactory
Naegleria :Amphotericin B, with miconazole and rifampinBalamuthia mandrillaris :albendazole and itraconazole
Conclusion
Pathogen Prevention
•Neisseria meningitidis
•MCV-4 •MPSV-4
•Haemophilus influenzae
•Hib vaccine
•Streptococcus pneumoniae
•PPSV23•PCV13•PCV7
•Mycobacterium tuberculosis
•BCG vaccination
Reference • Richard V. Goering, Hazel M. Dockrell, Mark
Zuckerman, Peter L. Chiodini, and Ivan M. Roitt, Mims’ Medical Microbiology,5th edition
• Ananthanarayan and Paniker , Textbook of Microbiology, 8th edition
• Prof CP Baveja, Textbook of Microbiology, 2nd edition
• http://www.cdc.gov/vaccines