IRCM: WHO ARE WE?

HISTORY

HISTORY

1952: Jacques Genest created the département de recherches cliniques at the Hôtel-Dieu

1967: Jacques Genest founded the IRCM

2012: 36 research units

THE IRCM’S UNIQUENESS

THE IRCM’S UNIQUENESS

Multidisciplinary research approach

Training of the next generation of scientists

Performance-based job permanency

Affiliated to the Université de Montréal; Associated with McGill University

Clinic associated with CHUM

THE IRCM IN 2010

THE IRCM IN 2012

425 researchers, employees and studentsFundamental and clinical research36 research units, grouped in 5 research programsBoard of Directors chaired by Louise Lambert-LagacéPresident and Scientific Director: Tarik Möröy

THE IRCM IN 2012

RESEARCH PROGRAMS

RESEARCH PROGRAMS

Systems biology and medicinal chemistry

Cancer

Immunity and viral infections

Cardiovascular and metabolic diseases

Neurobiology and development

SYSTEMS BIOLOGY AND MEDICINAL CHEMISTRY

SYSTEMS BIOLOGY AND MEDICINAL CHEMISTRY

Bioinformatics and Computational Genomics (Benjamin Haibe-Kains)

Ribonucleoprotein Biochemistry (Marlene Oeffinger)

Chemical Biology and Peptide Research (Peter W. Schiller)

RNA Biology (Éric Lécuyer)

Bio-organic Chemistry (Yvan Guindon)

Chromatin and Genomic Expression (François Robert)

Gene Transcription and Proteomics (Benoit Coulombe)

Molecular Virology (Jacques Archambault)

CANCER

CANCER

Endothelial Cell Biology (Jean-Philippe Gratton)

Mammary Cancer Biology (Katrina Podsypanina)

Cell Division and Centrosome Biology (William Y. Tsang)

Molecular Genetics and Development (Marie Trudel)

Hematopoiesis and Cancer (Tarik Möröy)

Cellular Interactions and Development (Jean Vacher)

Cytoskeletal Organization and Cell Migration (Jean-François Côté)

IMMUNITY AND VIRAL INFECTIONS

IMMUNITY AND VIRAL INFECTIONS

Molecular Biology (Paul Jolicœur)

Mechanisms of Genetic Diversity (Javier Marcelo Di Noia)

Molecular Oncology (André Veillette)

Molecular Immunology (Hua Gu)

Immune Regulation (Woong-Kyung Suh)

Human Retrovirology (Éric A. Cohen)

CARDIOVASCULAR AND METABOLIC DISEASES

CARDIOVASCULAR AND METABOLIC DISEASES (1/2)

Molecular Biochemistry of Hypertension (Timothy L. Reudelhuber)

Biochemical Neuroendocrinology (Nabil G. Seidah)

Experimental Cardiovascular Biology (Christian F. Deschepper)

Metabolic Diseases (Rémi Rabasa-Lhoret)

Cardiovascular Pharmacology (Pierre Larochelle)

Molecular Mechanisms of Diabetes (Jennifer Estall)

CARDIOVASCULAR AND METABOLIC DISEASES

CARDIOVASCULAR AND METABOLIC DISEASES (2/2)

Molecular Endocrinology (M. Ram Sairam)

Neuropeptide Structure and Metabolism (Claude Lazure)

NEUROBIOLOGY AND DEVELOPMENT

NEUROBIOLOGY AND DEVELOPMENT

Epithelial Cell Biology (David R. Hipfner)

Molecular Biology of Neural Development (Frédéric Charron)

Neural Circuit Development (Artur Kania)

Genetics and Development (Marie Kmita)

Molecular Genetics (Jacques Drouin)

Cellular Neurobiology (Michel Cayouette)

Neuroethics (Éric Racine)

CORE FACILITIES

CORE FACILITIES

Molecular Biology and Functional Genomics

DNA sequencing and genotyping

DNA chip reader (microarray)

Real-time PCR device

Alpha Imager 2000

ANIMAL FACILITIES

ANIMAL FACILITIES

38 employees (PSA, TSA and administration)Animal Facility 1 - Conventional: 830 m2 in renovation – summer 2011

2,700 mouse cages500 rats48 rabbits

Animal Facility 2 - SPF: 1,100 m2

7,000 mouse cages160 rat and Guinea pig cages

Animal Facility 3 – SPF+: 1,030 m2 5,000 mouse cages

TECHNOLOGY TRANSFER

TECHNOLOGY TRANSFER (since 1986)

80 technologies:Chemical compoundsChemical compound screening toolsDiagnostic toolsBiomedical devicesAnimal models of human diseases

62 technologies were the subject of patent applications, and 30 were issued patents

58 technologies are still active and/or under marketing analysis

38 technologies were part, at varying degrees, of a technology transfer process

CANADA RESEARCH CHAIRHOLDERS

CANADA RESEARCH CHAIRHOLDERS

Éric A. Cohen : Chair in human retrovirology

Javier Marcelo Di Noia : Chair in genetic diversity

Jean-Philippe Gratton : Chair in endothelial cell functional signalling

Paul Jolioeur : Chair in studies of pathogenesis of retrovirus-induced diseases

Marie Kmita : Chair in molecular embryology and genetics

Tarik Möröy : Chair in hematopoiesis and immune cell differentiation

Nabil G. Seidah : Chair in precursor proteolysis

André Veillette : Chair in immune system signalling

SCIENTIFIC PUBLICATIONS

SCIENTIFIC PUBLICATIONS (1967-2011)

6,728 scientific publications

An average of 198 publications per year since 1977

Articles in Cell, Circulation, Genes and Development, Nature, Nature Immunology, Science, Neuron

83 books published since 1967