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Session Four: Exploring the financial mechanisms that can be harnessed to increase investment in dementia. Mr. George Vradenburg, Convenor, The Global CEO Initiative on Alzheimer's and Chairman of USAgainstAlzheimer’s & World Dementia Council Member
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George VradenburgConvener, The Global CEO Initiative on Alzheimer’s Disease
Member, World Dementia Council
Changing the Game: How to Increase Resources
Devoted to Alzheimer’s
1
Mobilizing the Needed Resources
Increasing our Productivity
Increasing Investor Reward/Reducing their Risk
Innovative Finance Mechanisms and Approaches
2
Increasing our Productivity
Global Alzheimer’s Platform
3Examples only, not comprehensive
U.K.DementiaPlatform
Global Goals: Longitudinal Data, Biomarkers/Diagnostics, New Targets, Reduce Time/Cost to Market, Regulatory Alignment
Increasing Investor Reward/Reducing Risk
4
Mechanism Example
Reward: Extension ofExclusivity/IP Period
Orphan Drug Policy Changes
Risk: ShorteningDevelopment Times
HIV/AIDS; Biomarkers + Conditional Approval; Trial-Ready Infrastructure
Both: Reduce Uncertainty Accelerated and Globally Aligned Regulatory Pathways
►Here are mechanisms to change the risk/reward equation
►Each has been done elsewhere; we can do it
Drug Discovery/
Diagnostics
Care Delivery
VentureCapital
Drug Development
Arc of Disease Management
Finance Mechanisms - Today
Government Grants
5
Non-Profit,Philanthropy
Industry
Private Equity
Hedge Funds
Today
Innovative Finance Mechanisms and Approaches
Basic Research
Government
Drug Discovery/
Diagnostics
Care Delivery
Basic Research
VentureCapital
Drug Development
Arc of Disease Management
Finance Mechanisms – In The Future
Government Grants
6
Non-Profit,Philanthropy
Industry
Private Equity
Hedge Funds
Future
Government
SovereignWealth
Crowd Funding
Global Fund
Social Impact Bonds
Crowd Equity
Government
Drug Discovery/
Diagnostics
Care Delivery
Basic Research
VentureCapital
Drug Development
Arc of Disease Management
Finance Mechanisms – In The Future
Government Grants
7
Non-Profit,Philanthropy
Industry
Private Equity
Hedge Funds
FutureCrowd
Funding
Global Fund
Crowd Equity
Non-Profit, Philanthropy
&VentureCapital
Global Fund &
Government&
IndustrySovereign
Wealth
Social Impact Bonds
Government&
PrivateEquity
THANK YOU
8
Maike Stenull, Johnson & JohnsonLuc Truyen, Janssen (a Johnson & Johnson Company)Cynthia Duggan, New York Academy of Sciences
The Member Companies ofThe Global CEO Initiative on Alzheimer’s
