Generic Pamelor (Nortriptyline Hydrochloride)
Generic Pamelor (Nortriptyline Hydrochloride) is used for the
relief of symptoms of depression. Generic Pamelor is available as
Sensival Tablets and Primox Tablets.
Chemical Structure
Generic Pamelor (Nortriptyline Hydrochloride) is used for the
relief of symptoms of depression. Endogenous depressions are more
likely to be alleviated than are other depressive states.
Nortriptyline Hydrochloride is also used for the treatment of
nicotine dependence as an aid to smoking cessation.
Indications
Generic Pamelor is a tricyclic antidepressant that is used
for:
The active ingredient present in Generic Pamelor is
Nortriptyline Hydrochloride. Nortriptyline Hydrochloride is a white
to off-white powder, having a slight, characteristic odour. It is
soluble in water and in chloroform, sparingly soluble in methanol
and practically insoluble in most organic solvents.
Active Ingredient
How Does Generic Pamelor work?
Depression is thought to be caused by a chemical imbalance in
parts of the brain. This affects your whole body and can cause
emotional and physical symptoms such as feeling low in spirit, loss
of interest in activities, being unable to enjoy life, poor
appetite or overeating, disturbed sleep, often waking up early,
loss of sex drive, lack of energy and feeling guilty over
nothing.
How Does Generic Pamelor work?
Generic Pamelor works by correcting this chemical imbalance and
helps relieve the symptoms of depression.
For the Relief of Symptoms of Depression:The recommended adult
dose is 25 mg 3 or 4 times daily. The dosage should begin at a low
level and be increased as required.
Doses above 100 mg per day are not recommended.
In case of elderly patients, the dosage is 25 mg to 50 mg per
day, in divided doses.
Recommended Adult Dosage
As an Aid in Smoking Cessation:Nortriptyline HCl is administered
orally in the form of tablets. The therapy is started
prior to quit date at 25 mg/day and then increased to 75 100mg
when feasible over 10 days to 5 weeks. The recommended starting
time is 10 to 28 days before the quit date and gradually increased
to achieve a maintenance dose of 75 100 mg/day when possible for a
total of up to 12 weeks.
Recommended Adult Dosage
Missed Dose
If you miss a dose, take it as soon as you remember. However, if
you remember when it is almost time for your next dose, take only
your usual dose at that time.
Contraindications
Generic Pamelor (Primox Tablets / Sensival Tablets) are
contraindicated in the following cases:
Known hypersensitivity to Nortriptyline HCl or any inactive
ingredients of this medication.
Use of Generic Pamelor (Nortriptyline HCl) or other tricyclic
antidepressants concurrently with amonoamine oxidase (MAO)
inhibitor is contraindicated. The MAO inhibitor has to be
discontinued for at least two weeks before treatment with Pamelor
(Nortriptyline HCl) is started.
Contraindications
Generic Pamelor (Primox Tablets / Sensival Tablets) are
contraindicated in the following cases:
Cross-sensitivity between Pamelor (Nortriptyline HCl) and other
dibenzazepines is a possibility.
Side Effects of Generic Pamelor
The side effects of Generic Pamelor (Primox Tablets / Sensival
Tablets) Cardiovascular: Hypotension, hypertension, tachycardia,
palpitation, myocardial infarction, arrhythmias, heart block,
stroke.Psychiatric: Confusional states (especially in the elderly)
with hallucinations, disorientation, delusions; anxiety,
restlessness, agitation; insomnia, panic, nightmares; hypomania;
exacerbation of psychosis.
Side Effects of Generic Pamelor
Neurologic: Numbness, tingling, paresthesias of extremities;
incoordination, ataxia, tremors; peripheral neuropathy;
extrapyramidal symptoms; seizures, alteration in EEG patterns;
tinnitus.Anticholinergic: Dry mouth and, rarely, associated
sublingual adenitis; blurred vision, disturbance of accommodation,
mydriasis; constipation, paralytic ileus; urinary retention,
delayed micturition, dilation of the urinary tract.
Side Effects of Generic Pamelor
Allergic: Skin rash, petechiae, urticaria, itching,
photosensitization (avoid excessive exposure to sunlight); edema
(general or of face and tongue), drug fever, cross-sensitivity with
other tricyclic drugs.Hematologic: Bone marrow depression,
including agranulocytosis; eosinophilia; purpura;
thrombocytopenia.
Side Effects of Generic Pamelor
Gastrointestinal: Nausea and vomiting, anorexia, epigastric
distress, diarrhea, peculiar taste, stomatitis, abdominal cramps,
black tongue.Endocrine: Gynecomastia in the male, breast
enlargement and galactorrhea in the female; increased or decreased
libido, impotence; testicular swelling; elevation or depression of
blood sugar levels; syndrome of inappropriate ADH (antidiuretic
hormone) secretion.
Side Effects of Generic Pamelor
Other: Jaundice (simulating obstructive), altered liver
function; weight gain or loss; perspiration; flushing; urinary
frequency, nocturia; drowsiness, dizziness, weakness, fatigue;
headache; parotid swelling; alopecia.Withdrawal Symptoms: Abrupt
cessation of treatment after prolonged therapy may produce nausea,
headache, and malaise.
Warnings And Precautions
Patients of any age with Major Depressive Disorder may
experience worsening of their depression and/or the emergence of
suicidal ideation and behaviour (suicidality), whether or not they
are taking antidepressant medications, and this risk may persist
until significant improvement occurs. Patients should be closely
monitored, especially at the beginning of therapy or when the dose
is changed, until such improvement occurs. The possible risk of
increased suicidality in patients applies to all classes of
antidepressant medicines.
Warnings And Precautions
Before starting treatment with an antidepressant, patients
should be adequately screened to determine if they are at risk for
bipolar disorder.
Excessive consumption of alcohol in combination with
Nortriptyline (Generic Pamelor) therapy may have a potentiating
effect, which may lead to the danger of increased suicidal attempts
or overdosage especially in patients with histories of emotional
disturbances or suicidal ideation. Therefore consumption of alcohol
during (Primox Tablets / Sensival Tablets) treatment should be
minimal or avoided.
Overdosage Symptoms
Symptoms of overdose include cardiac dysrhythmias, severe
hypotension, shock, congestive heart failure, pulmonary edema,
convulsions, and CNS depression, including coma. Changes in the
electrocardiogram, are clinically significant indicators of
tricyclic antidepressant toxicity.
Overdosage Symptoms
Other signs of overdose may include confusion, restlessness,
disturbed concentration, transient visual hallucinations, dilated
pupils, agitation, hyperactive reflexes, stupor, drowsiness, muscle
rigidity, vomiting, hypothermia, hyperpyrexia, or any of the acute
symptoms under side effects.
Overdose Treatment
Obtain an ECG and immediately initiate cardiac monitoring.
Protect the patients airway, establish an intravenous line and
initiate gastric decontamination. A minimum of six hours of
observation with cardiac monitoring and observation for signs of
CNS or respiratory depression, hypotension, cardiac dysrhythmias
and/or conduction blocks, and seizures is necessary. If signs of
toxicity occur at any time during this period, extended monitoring
is required.
Overdose Treatment
Gastrointestinal Decontamination: All patients suspected of
tricyclic antidepressant overdose should receive gastrointestinal
decontamination. This should include large volume gastric lavage
followed by activated charcoal. If consciousness is impaired, the
airway should be secured prior to lavage. Emesis (Vomiting) is
contraindicated.
Primox Tablets manufactured by Sun Pharmaceutical Industries
Sensival Tablets manufactured by Wallace LifeStyle, India
For more information click here
Generic Pamelor Tablets
The Swiss Pharmacy, Geneva Switzerland
