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thrombocytopenia
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Etiologies of Acute Thrombocytopenia
ACD09/12/2014
Kevin KuriakosePGY-3UAMS
Pathophysiology
• Decreased production• Increased destruction• Increased consumption• Redistribution• Dilution
Infection
• Viral: HIV, Mumps, Rubella, Parvo, Hep C, EBV, Dengue
• Bacterial: – Sepsis (BM suppression, DIC, TTP/HUS)– Tick borne illnesses– H pylori, Leptospirosis, Brucellosis
• Parasites: Malaria, Babesiosis
Immunological/Rheumatological
• ITP• SLE (Secondary ITP)• Drugs• HIT• APS• RA (Felty’s Syndrome)
Felty’s Syndrome
RA Splenomegaly
Bernard Soulier Syndrome
Evan’s Syndrome
Warm AIHA and ITP
Drugs
• Ampicillin• Zosyn• Vancomycin• Rifampin• Phenytoin• Carbamazepine• Quinine• Sulfonamides
Bone Marrow
• Malignancies – The disease and the treatment• PNH• MDS• Aplastic Anemia
Others
• Hypersplenism• Alcohol• Nutrient deficiencies• Pregnancy• Congenital (Bernard Soulier Syndrome)
Thank you