54
||´ÉÏ kÉluÉÇiÉUÏ lÉqÉ:||

Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Embed Size (px)

Citation preview

Page 1: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

||´ÉÏ kÉluÉÇiÉUÏlÉqÉ:||

Page 2: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

DISSERTATION TITLE“A LITERAL STUDY OF CHARAKOKTA KASA

CHIKITSA ADHHAYA AND CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN

VATAJ KASA.”

DISSERTATION TITLE“A LITERAL STUDY OF CHARAKOKTA KASA

CHIKITSA ADHHAYA AND CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN

VATAJ KASA.”Vd. Bhushan D. Mhaiskar( Final Year. P. G. Scholar)Guided By: Vd. Bhushan D. Mhaiskar( Final Year. P. G. Scholar)Guided By: Guided By:

ReaderDr. Sachin S. Waghmare, HOD

Dr.S.G.KulkarniDr.S.G.KulkarniDept.of Ayurved Samhita and SiddhantYashwant Ayurvedic College P.G.T. & R.C. KodoliYear 2013-2014

Guided By: Reader

Dr. Sachin S. Waghmare, HODDr.S.G.KulkarniDr.S.G.KulkarniDept.of Ayurved Samhita and SiddhantYashwant Ayurvedic College P.G.T. & R.C. KodoliYear 2013-2014

Page 3: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

INTRODUCTIONINTRODUCTION– Ayurveda is a well established immortal science with

ageless concrete fundamentals.– Need of the study on this topic because a number of

drugs have been mentioned .but Sauwarchaldi churnais one classical formulation which has been in

– Ayurveda is a well established immortal science withageless concrete fundamentals.

– Need of the study on this topic because a number ofdrugs have been mentioned .but Sauwarchaldi churnais one classical formulation which has been inis one classical formulation which has been inpractice since ancient times..is one classical formulation which has been inpractice since ancient times..

Page 4: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• The human body is continuously under the influence ofenvironmental changes; quality of life on whole earth isdeteriorating day by day due to pollution andurbanization. As a result of “Dhuma” and “Raja” themain causes of Pranavahasroto dusti, which have become

• The human body is continuously under the influence ofenvironmental changes; quality of life on whole earth isdeteriorating day by day due to pollution andurbanization. As a result of “Dhuma” and “Raja” themain causes of Pranavahasroto dusti, which have becomemain causes of Pranavahasroto dusti, which have becomeunavoidable, are making Kasa the most common diseaseof total diseases being recorded.

• Disease kasa is found all over the globe and in all age groups. The word kasa is derived from ‘kasati Iti kasan’.

main causes of Pranavahasroto dusti, which have becomeunavoidable, are making Kasa the most common diseaseof total diseases being recorded.

• Disease kasa is found all over the globe and in all age groups. The word kasa is derived from ‘kasati Iti kasan’.

Page 5: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• The disease kasa is as old as life and references to this effect can befound since Vedic period. Our ancient system of medicine hasdescribed all the characteristics of the disease kasa.

• Though kasa is seen as symptoms in many diseases like pandu.Kshay, rajyakshma. Kasa; cough is one of commonest symptomsin day to day practice. In Ayurveda, kasa classified as five types incontexts Acharya charaka explains every remedy for it. To avoidthe further complications, like kasa bhaishajya sangraha, in whichall remedies and pathya apathya are given.

• The disease kasa is as old as life and references to this effect can befound since Vedic period. Our ancient system of medicine hasdescribed all the characteristics of the disease kasa.

• Though kasa is seen as symptoms in many diseases like pandu.Kshay, rajyakshma. Kasa; cough is one of commonest symptomsin day to day practice. In Ayurveda, kasa classified as five types incontexts Acharya charaka explains every remedy for it. To avoidthe further complications, like kasa bhaishajya sangraha, in whichall remedies and pathya apathya are given.all remedies and pathya apathya are given.

• From this prospect the study, evaluation of the clinical effect of Sauvarchaladi churna in vataja kasa. has been taken into account with a time span of twenty eight days treatment.

all remedies and pathya apathya are given.• From this prospect the study, evaluation of the clinical effect of

Sauvarchaladi churna in vataja kasa. has been taken into account with a time span of twenty eight days treatment.

5

Page 6: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• In classics Sauvarchaladi churna is mentioned in Vataja kasa,but this formulation is made to Yawa kshar, Sauvarchal lavan.Amalaki, Haritaki, Pippali, Nagar by adding anupana with Go-grita. Its pharmaceutical action starts from the mouth itself,because of presence of more quantity of Pippali, Lavan, andAmalaki. 60 patients from outpatient department of Hospitalwere scrutinized and considered for the study.

• The easiest and efficient way to manage the patient by least

• In classics Sauvarchaladi churna is mentioned in Vataja kasa,but this formulation is made to Yawa kshar, Sauvarchal lavan.Amalaki, Haritaki, Pippali, Nagar by adding anupana with Go-grita. Its pharmaceutical action starts from the mouth itself,because of presence of more quantity of Pippali, Lavan, andAmalaki. 60 patients from outpatient department of Hospitalwere scrutinized and considered for the study.

• The easiest and efficient way to manage the patient by least• The easiest and efficient way to manage the patient by leastmedicine . Scholar decided the Mode of administration of drugis oral to manage the Vataj kasa

• The Potency of classical formulation should be evaluatedclinically to give better option for Vataj kasa treatment withminimal side effect.

• The easiest and efficient way to manage the patient by leastmedicine . Scholar decided the Mode of administration of drugis oral to manage the Vataj kasa

• The Potency of classical formulation should be evaluatedclinically to give better option for Vataj kasa treatment withminimal side effect.

Page 7: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Thus scholar has planned “A Literal study of charakokta kasachikitsa adhhaya and clinical assessment of Sauvarchaladi churnain Vataj kasa.” to evaluate the relative merit of the oraladministration of the Sauvarchaladi churna with Go-ghrita asanupana. With following aims and objectives.

• Thus scholar has planned “A Literal study of charakokta kasachikitsa adhhaya and clinical assessment of Sauvarchaladi churnain Vataj kasa.” to evaluate the relative merit of the oraladministration of the Sauvarchaladi churna with Go-ghrita asanupana. With following aims and objectives.

7

Page 8: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

AIMS AND OBJECTIVES AIMS AND OBJECTIVES 1. To make literal study of charakokta Kas chikitsa

addhaya.2. To analyze the etiopathogenesis of kasa.3. To study efficacy of Sauwarchaldi churna on Vataj

kasa on basis of basic principles, and siddhant.4. To validate the clinical efficacy of sauwarchaladi

1. To make literal study of charakokta Kas chikitsaaddhaya.

2. To analyze the etiopathogenesis of kasa.3. To study efficacy of Sauwarchaldi churna on Vataj

kasa on basis of basic principles, and siddhant.4. To validate the clinical efficacy of sauwarchaladi4. To validate the clinical efficacy of sauwarchaladi

churna on scientific parameters in vataj kasa.4. To validate the clinical efficacy of sauwarchaladi

churna on scientific parameters in vataj kasa.

8

Page 9: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

CONCEPTUAL STUDYCONCEPTUAL STUDY• HISTORICAL REVIEW• Prior to proper understanding and discussing the subject

Vataj Kasa and its treatment, it would be quite relevant to review the references cited in ancient and modern times.

• “KASA” – the reference for this disease is available from the Vedic kala to Adhunika kala. The historical review of the disease Kasa is described in chronological order

• HISTORICAL REVIEW• Prior to proper understanding and discussing the subject

Vataj Kasa and its treatment, it would be quite relevant to review the references cited in ancient and modern times.

• “KASA” – the reference for this disease is available from the Vedic kala to Adhunika kala. The historical review of the disease Kasa is described in chronological order the disease Kasa is described in chronological order below:-

• 1. Poorva Kala: a.Veda kala• b.Purana kala• c.Samhita kala• 2 . Madhyama kala• 3. Adhunika kala

the disease Kasa is described in chronological order below:-

• 1. Poorva Kala: a.Veda kala• b.Purana kala• c.Samhita kala• 2 . Madhyama kala• 3. Adhunika kala

Page 10: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• After reviewing historical background of the disease Kasa, it is significant to study the Vyutpatti, Nirukti and Paryaya of the word Kasa.

• ``iÉmÉxÉÉ rÉzÉxÉÉ kÉ×irÉÉ ÍkÉrÉÉ cÉ mÉUrÉÉÎluÉiÉ:|AɧÉårÉ: MüÉxÉ zÉÉlirÉjÉï mÉëÉWû ÍxÉkSÇ ÍcÉÌMüÎixÉiÉqÉç||'‘

cÉ.ÍcÉ.18/3With divine power and long lasting persiverence acharya Atreyastated the divine, siddha line of Treatment of kasa in Kasa

• After reviewing historical background of the disease Kasa, it is significant to study the Vyutpatti, Nirukti and Paryaya of the word Kasa.

• ``iÉmÉxÉÉ rÉzÉxÉÉ kÉ×irÉÉ ÍkÉrÉÉ cÉ mÉUrÉÉÎluÉiÉ:|AɧÉårÉ: MüÉxÉ zÉÉlirÉjÉï mÉëÉWû ÍxÉkSÇ ÍcÉÌMüÎixÉiÉqÉç||'‘

cÉ.ÍcÉ.18/3With divine power and long lasting persiverence acharya Atreyastated the divine, siddha line of Treatment of kasa in Kasastated the divine, siddha line of Treatment of kasa in Kasachikista 18nth addhay.

• Derivation of Kasa:-`` MüxÉ aÉÌiÉ-zÉÉiÉlÉrÉÉå CirÉxrÉ kÉÉiÉÉåUrÉÇmÉërÉÉåaÉÈ||'' cÉ¢ümÉÉÍhÉ.

• According to Chakrapaani, the word Kasa is derived from “kas” and gives the meaning “gati shaatanayoh" means "to fall". The Commentator Gangadharadescribed Kasa as “bhinnaswara” when “gater” pratyaya is added to the root “kas” which gives the meaning gati- movement (Panini).

stated the divine, siddha line of Treatment of kasa in Kasachikista 18nth addhay.

• Derivation of Kasa:-`` MüxÉ aÉÌiÉ-zÉÉiÉlÉrÉÉå CirÉxrÉ kÉÉiÉÉåUrÉÇmÉërÉÉåaÉÈ||'' cÉ¢ümÉÉÍhÉ.

• According to Chakrapaani, the word Kasa is derived from “kas” and gives the meaning “gati shaatanayoh" means "to fall". The Commentator Gangadharadescribed Kasa as “bhinnaswara” when “gater” pratyaya is added to the root “kas” which gives the meaning gati- movement (Panini).

Page 11: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Definition of Kasa:

`` zÉÑwMüÉå uÉÉ xÉMüTüÉå uÉÉÅÌmÉ MüxÉÉlÉÉiÉç MüÉxÉEcrÉiÉå'' || (cÉ.ÍcÉ.18/8)• This means the production of abnormal sound in the process which

may be productive or dry.

`` EU:mÉëpÉëÑÌiÉzÉiÉlÉÉŠ ‘MüÉxÉ’ CirÉluÉjÉïxÉÇ¥ÉrÉÉåcrÉÉiÉå'' || cÉ¢ümÉÉÍhÉ-cÉ.ÍcÉ.18/8)

• Definition of Kasa:

`` zÉÑwMüÉå uÉÉ xÉMüTüÉå uÉÉÅÌmÉ MüxÉÉlÉÉiÉç MüÉxÉEcrÉiÉå'' || (cÉ.ÍcÉ.18/8)• This means the production of abnormal sound in the process which

may be productive or dry.

`` EU:mÉëpÉëÑÌiÉzÉiÉlÉÉŠ ‘MüÉxÉ’ CirÉluÉjÉïxÉÇ¥ÉrÉÉåcrÉÉiÉå'' || cÉ¢ümÉÉÍhÉ-cÉ.ÍcÉ.18/8)• Means that shareera especially urapradesh shows falling posture while

coughing.• Nidaana of Kasa:

`` iÉxrÉÉåmÉsÉÎokÉÌlÉïSÉlÉmÉÔuÉïÃmÉÍsÉ…ûÉåÇmÉzÉrÉxÉÇmÉëÉÎmiÉiÉ:''||6|| cÉ.ÌlÉ.1/6• Nidaana is categorized broadly into two main divisions;

1. Samanya Nidaana (General causative factor) 2. Vishesha Nidaana (Specific causative factor)

• Means that shareera especially urapradesh shows falling posture while coughing.

• Nidaana of Kasa:`` iÉxrÉÉåmÉsÉÎokÉÌlÉïSÉlÉmÉÔuÉïÃmÉÍsÉ…ûÉåÇmÉzÉrÉxÉÇmÉëÉÎmiÉiÉ:''||6|| cÉ.ÌlÉ.1/6

• Nidaana is categorized broadly into two main divisions;1. Samanya Nidaana (General causative factor) 2. Vishesha Nidaana (Specific causative factor)

Page 12: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Types of kasa• Acharya charaka explains primordily classify kasa into five types. In the

classics like Charaka Samhita, Astanga Hrudya, Bhavaprakasa, Yogaratnakara, Madhavanidana, Gada Nigraha and Bhela Samhita, the authors opined that there are only five types of kasa namely.

• 1. Vataja kasa, • 2. Pittaja kasa • 3. Kaphaja kasa

• Types of kasa• Acharya charaka explains primordily classify kasa into five types. In the

classics like Charaka Samhita, Astanga Hrudya, Bhavaprakasa, Yogaratnakara, Madhavanidana, Gada Nigraha and Bhela Samhita, the authors opined that there are only five types of kasa namely.

• 1. Vataja kasa, • 2. Pittaja kasa • 3. Kaphaja kasa • 4. Kshataja kasa• 5. Kshayaj kasa• Roopa of Kasa

• ``™imÉɵÉÉåïU: ÍzÉU:zÉÔsÉxuÉUpÉåSèMüUÉå pÉ×zÉqÉ| zÉÑwMüÉåU:MÇüPûuÉY§ÉxrÉ ™wOèsÉÉåqlÉ: mÉëiÉÉqrÉiÉ:||11||ÌlÉbÉÉåïwÉSãlrÉxiÉlÉlÉSÉæï¤ÉÉåpÉqÉÉåyM×üiÉ| zÉÑwMüMüÉxÉ: MüÄTüzÉÑwMÇü M×ücNûÉlÉ qÉÑYiuÉÉÅsmÉiÉÉÇ uÉëeÉåiÉ||12||''cÉ.ÍcÉ.18/13

• 4. Kshataja kasa• 5. Kshayaj kasa• Roopa of Kasa

• ``™imÉɵÉÉåïU: ÍzÉU:zÉÔsÉxuÉUpÉåSèMüUÉå pÉ×zÉqÉ| zÉÑwMüÉåU:MÇüPûuÉY§ÉxrÉ ™wOèsÉÉåqlÉ: mÉëiÉÉqrÉiÉ:||11||ÌlÉbÉÉåïwÉSãlrÉxiÉlÉlÉSÉæï¤ÉÉåpÉqÉÉåyM×üiÉ| zÉÑwMüMüÉxÉ: MüÄTüzÉÑwMÇü M×ücNûÉlÉ qÉÑYiuÉÉÅsmÉiÉÉÇ uÉëeÉåiÉ||12||''cÉ.ÍcÉ.18/13

Page 13: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

`` AkÉ:mÉëÌiÉWûiÉÉå uÉÉrÉÑÂkuÉx§ÉÉåiÉ:| ESÉlÉpÉÉuÉqÉÉmɳÉ: MühPåûxÉ£üjÉÉåUÍxÉ ||6||AÌuÉzrÉ ÍzÉUxÉ: ZÉÉÌlÉ xÉuÉÉïÍhÉ mÉëÌiÉmÉÑUlÉ| AÉpÉleɳÉͤÉmÉlÉ SåWÇûWûlÉÑqÉlrÉå iÉjÉÉÅͤÉhÉÏ ||7|| lÉå§Éå mÉ׸qÉÑU:mÉɵÉåï ÌlÉpÉÑïerÉ xiÉqpÉrÉÇxiÉiÉ:| zÉÑwMüÉå uÉÉ xÉMüTüÉåuÉÉÅÌmÉ MüxÉlÉÉiMüÉxÉ EŠiÉå'' ||8||

cÉ.ÍcÉ.18/6,7,8Sampraapti deals with all the pathological process, which are responsible for clinical signs and symptoms of the disease. Samprapti helps to understand how the disease has

`` AkÉ:mÉëÌiÉWûiÉÉå uÉÉrÉÑÂkuÉx§ÉÉåiÉ:| ESÉlÉpÉÉuÉqÉÉmɳÉ: MühPåûxÉ£üjÉÉåUÍxÉ ||6||AÌuÉzrÉ ÍzÉUxÉ: ZÉÉÌlÉ xÉuÉÉïÍhÉ mÉëÌiÉmÉÑUlÉ| AÉpÉleɳÉͤÉmÉlÉ SåWÇûWûlÉÑqÉlrÉå iÉjÉÉÅͤÉhÉÏ ||7|| lÉå§Éå mÉ׸qÉÑU:mÉɵÉåï ÌlÉpÉÑïerÉ xiÉqpÉrÉÇxiÉiÉ:| zÉÑwMüÉå uÉÉ xÉMüTüÉåuÉÉÅÌmÉ MüxÉlÉÉiMüÉxÉ EŠiÉå'' ||8||

cÉ.ÍcÉ.18/6,7,8Sampraapti deals with all the pathological process, which are responsible for clinical signs and symptoms of the disease. Samprapti helps to understand how the disease has

Sampraapti of Kasa:-

signs and symptoms of the disease. Samprapti helps to understand how the disease has manifested after nidaana Sevana

Intensity of Types of kasa``uÉÉiÉÉÌSeÉÉx§ÉrÉÉæ rÉå cÉ ¤ÉiÉeÉ ¤ÉrÉeÉxiÉjÉÉ | mÉlcÉãiÉå xrÉÑlÉ×hÉÉÇuÉkÉïqÉÉlÉÉ: ¤ÉrÉmÉëSÉÈ||'' cÉ.ÍcÉ.18/4

Acharya charaka Said that these five types of Kasa are one stronger than previous type.Hence we do treatment in order to avoid further compliaction.

signs and symptoms of the disease. Samprapti helps to understand how the disease has manifested after nidaana Sevana

Intensity of Types of kasa``uÉÉiÉÉÌSeÉÉx§ÉrÉÉæ rÉå cÉ ¤ÉiÉeÉ ¤ÉrÉeÉxiÉjÉÉ | mÉlcÉãiÉå xrÉÑlÉ×hÉÉÇuÉkÉïqÉÉlÉÉ: ¤ÉrÉmÉëSÉÈ||'' cÉ.ÍcÉ.18/4

Acharya charaka Said that these five types of Kasa are one stronger than previous type.Hence we do treatment in order to avoid further compliaction.

Page 14: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

REVIEW ON VATAJA KASAREVIEW ON VATAJA KASA• Derivation:-

``uÉÉÅ + iÉè + eÉÉ'‘• Etymologically the word "Vataj Kasa" consists of two components

viz., Vataj and Kasa. Vata - The word Vata belongs to pulling derivedfrom the root van- gait gandhnayo"tha" prathyaya giving the meaning"to move", "to make known", "and to enlighten". Ja means “producedby" Kasa It is derived from Kas dhaatu "gater" pratyaya

• Definition:-

• Derivation:-``uÉÉÅ + iÉè + eÉÉ'‘

• Etymologically the word "Vataj Kasa" consists of two componentsviz., Vataj and Kasa. Vata - The word Vata belongs to pulling derivedfrom the root van- gait gandhnayo"tha" prathyaya giving the meaning"to move", "to make known", "and to enlighten". Ja means “producedby" Kasa It is derived from Kas dhaatu "gater" pratyaya

• Definition:-• Definition:-Vataja:-

• ``uÉÉ aÉÌiÉ aÉlkÉlÉrÉÉåÈ uÉÉÌiÉ aÉcNûiÉÏÌiÉ |'' (UhÉÎeÉiÉç UÉrÉ SåxÉÉrÉÏ)• That which gives movement (gati), knowledge (jnaana) and

enlightment (utsaaha/gandhana) to the shareera. Vataj means thatwhich is produced by Vata which is one of the doshaa in the body.Kasa Expulsion of the praana vaayu resulting in the production ofsound resembling that of a broken bronze vessel is called Kasa.

• Definition:-Vataja:-

• ``uÉÉ aÉÌiÉ aÉlkÉlÉrÉÉåÈ uÉÉÌiÉ aÉcNûiÉÏÌiÉ |'' (UhÉÎeÉiÉç UÉrÉ SåxÉÉrÉÏ)• That which gives movement (gati), knowledge (jnaana) and

enlightment (utsaaha/gandhana) to the shareera. Vataj means thatwhich is produced by Vata which is one of the doshaa in the body.Kasa Expulsion of the praana vaayu resulting in the production ofsound resembling that of a broken bronze vessel is called Kasa.

Page 15: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Nidaana of Vataj Kasa According to Charak –•

``¤ÉzÉÏiÉMüwÉÉrÉÉsmÉmÉëÍqÉiÉÉzÉlÉÇ Îx§ÉrÉ: | uÉåaÉkÉÉUhÉqÉÉrÉÉxÉÉå uÉÉiÉMüÉxÉmÉëuÉiÉïMüÉ:||'' cÉ.ÍcÉ.18/10• Acharya Charak explains the nidana of kasa in C.chi 18/10, as they

commonly hetu associated with vataja kasa as follows-• Rookshaaharasevana• Sheetaaharasevana• Kasaya rasa sevana

• Nidaana of Vataj Kasa According to Charak –•

``¤ÉzÉÏiÉMüwÉÉrÉÉsmÉmÉëÍqÉiÉÉzÉlÉÇ Îx§ÉrÉ: | uÉåaÉkÉÉUhÉqÉÉrÉÉxÉÉå uÉÉiÉMüÉxÉmÉëuÉiÉïMüÉ:||'' cÉ.ÍcÉ.18/10• Acharya Charak explains the nidana of kasa in C.chi 18/10, as they

commonly hetu associated with vataja kasa as follows-• Rookshaaharasevana• Sheetaaharasevana• Kasaya rasa sevana• Kasaya rasa sevana• Alpa bhojana• Pramita bhojana• Annashan• Ati stree sevana• Vegadharana• Ati ayasa

• Kasaya rasa sevana• Alpa bhojana• Pramita bhojana• Annashan• Ati stree sevana• Vegadharana• Ati ayasa

Page 16: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• POORVARUPAmÉÔuÉïÃmÉÇ pÉuÉå¨ÉåwÉÉ vÉÕM mÉÔhÉï aÉsÉÉxrÉiÉÉ MÇPå MÇQ旅 pÉÉåerÉÉlÉÉqÉuÉUÉåkÉ¶É eÉÉrÉiÉå |'' cÉÄ ÌcÉÄ 18/5

The poorvarupa is defined as the stage where premonitory symptoms appearimmediately after sthanasamsharaya. In this stage, clinical manifestation of the diseasestarts.

• RUPA• Charaka and vagbhatta has explained almost similar symptoms of vataj Kasa as –

• POORVARUPAmÉÔuÉïÃmÉÇ pÉuÉå¨ÉåwÉÉ vÉÕM mÉÔhÉï aÉsÉÉxrÉiÉÉ MÇPå MÇQ旅 pÉÉåerÉÉlÉÉqÉuÉUÉåkÉ¶É eÉÉrÉiÉå |'' cÉÄ ÌcÉÄ 18/5

The poorvarupa is defined as the stage where premonitory symptoms appearimmediately after sthanasamsharaya. In this stage, clinical manifestation of the diseasestarts.

• RUPA• Charaka and vagbhatta has explained almost similar symptoms of vataj Kasa as –• Charaka and vagbhatta has explained almost similar symptoms of vataj Kasa as –

`™imÉɵÉÉåïU: ÍzÉU:zÉÔsÉxuÉUpÉåSèMüUÉå pÉ×zÉqÉ| zÉÑwMüÉåU:MÇüPûuÉY§ÉxrÉ ™¾wOèsÉÉåqlÉ: mÉëiÉÉqrÉiÉ:||11||ÌlÉbÉÉåïwÉSãlrÉxiÉlÉlÉSÉæï¤ÉÉåpÉqÉÉåyM×üiÉ| zÉÑwMüMüÉxÉ: MüÄTüzÉÑwMÇüM×ücNûÉlÉ qÉÑYiuÉÉÅsmÉiÉÉÇuÉëeÉåiÉ||12||' ...cÉ.ÍcÉ.18/13

• SAMPRAPTI `AkÉ CirÉÉÌS | ESÉlÉpÉÉuÉqÉÉmÉ³É CÌiÉ FkuÉïaÉÌiÉ xuÉpÉÉuÉqÉmɳÉ:| ZÉÉlÉÏÌiÉx§ÉÉåiÉÉÍxÉÇ|' ||18|| cÉ¢ümÉÉÍhÉ.

• After discussing nidana, it is very essential to describe the samprapti of the disease, because samprapti includes all the pathological stages starting from the very contact of the body with the etiological factors until the manifestation of the disease and its

• Charaka and vagbhatta has explained almost similar symptoms of vataj Kasa as –`™imÉɵÉÉåïU: ÍzÉU:zÉÔsÉxuÉUpÉåSèMüUÉå pÉ×zÉqÉ| zÉÑwMüÉåU:MÇüPûuÉY§ÉxrÉ ™¾wOèsÉÉåqlÉ: mÉëiÉÉqrÉiÉ:||11||ÌlÉbÉÉåïwÉSãlrÉxiÉlÉlÉSÉæï¤ÉÉåpÉqÉÉåyM×üiÉ| zÉÑwMüMüÉxÉ: MüÄTüzÉÑwMÇüM×ücNûÉlÉ qÉÑYiuÉÉÅsmÉiÉÉÇuÉëeÉåiÉ||12||' ...cÉ.ÍcÉ.18/13

• SAMPRAPTI `AkÉ CirÉÉÌS | ESÉlÉpÉÉuÉqÉÉmÉ³É CÌiÉ FkuÉïaÉÌiÉ xuÉpÉÉuÉqÉmɳÉ:| ZÉÉlÉÏÌiÉx§ÉÉåiÉÉÍxÉÇ|' ||18|| cÉ¢ümÉÉÍhÉ.

• After discussing nidana, it is very essential to describe the samprapti of the disease, because samprapti includes all the pathological stages starting from the very contact of the body with the etiological factors until the manifestation of the disease and its

Page 17: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

DRUG INDICATION IN TEXTDRUG INDICATION IN TEXTThe indicated text for use of Sauwarchaladi

churna in vataj kasa described in charakSamhita.

xÉÉæuÉcÉïsÉÉpÉrÉÉ kÉɧÉÏ ÌmÉmmÉsÉÏ

The indicated text for use of Sauwarchaladichurna in vataj kasa described in charakSamhita.

xÉÉæuÉcÉïsÉÉpÉrÉÉ kÉɧÉÏ ÌmÉmmÉsÉÏxÉÉæuÉcÉïsÉÉpÉrÉÉ kÉɧÉÏ ÌmÉmmÉsÉÏार lÉÉaÉUqÉç |cÉÔÍhÉïiÉÇ xÉÌmÉïïwÉÉuÉÉiÉMüÄTüMüÉxÉWûUÇ िपबेत् ||

cÉ.ÍcÉ.18/122

xÉÉæuÉcÉïsÉÉpÉrÉÉ kÉɧÉÏ ÌmÉmmÉsÉÏार lÉÉaÉUqÉç |cÉÔÍhÉïiÉÇ xÉÌmÉïïwÉÉuÉÉiÉMüÄTüMüÉxÉWûUÇ िपबेत् ||

cÉ.ÍcÉ.18/122 17

Page 18: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• A literature reviewed of Vataj kasa & Drug taken from ayurveda text.

• A literature reviewed of Vataj kasa & Drug taken from ayurveda text.

18

Page 19: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Drug Review:Drug Review:1. Trial Drug - Sauwarchaladi churna as

described in charak samhitaAnupan- Goghrita

2. Control Drug – Shati churna

1. Trial Drug - Sauwarchaladi churna asdescribed in charak samhitaAnupan- Goghrita

2. Control Drug – Shati churna2. Control Drug – Shati churnaAnupan- Goghrita

2. Control Drug – Shati churnaAnupan- Goghrita

19

Page 20: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Ingredients of Sauwarchaladi churna :-

Ingredients of Sauwarchaladi churna :-

Sr.NoSr.No.. DravyaDravya Latin NameLatin Name GunaGuna1.1. SauwarchalSauwarchal churnachurna UnqaUnqa sodiumsodium chloridechloride Sukshma,laghuSukshma,laghu,,

ushnaushna22.. HaritakiHaritaki TerminaliaTerminalia ChebulaChebula Laghu,rukshaLaghu,ruksha22.. HaritakiHaritaki TerminaliaTerminalia ChebulaChebula Laghu,rukshaLaghu,ruksha33.. AmalakiAmalaki EmblicaEmblica OfficinalisOfficinalis Guru,ruksha,sheetGuru,ruksha,sheet44.. PippaliPippali PiperPiper longumlongum Anuanshna,snigdhaAnuanshna,snigdha,,

laghulaghu55.. YawaYawa ksharakshara Alkali of Alkali of HordeumHordeum

vulgarevulgare((KsharKshar))Tikhsna,ushna,Laghu,rukshaTikhsna,ushna,Laghu,ruksha,,kledkarkledkar

66.. shunthishunthi ZinzibarZinzibar officinaleofficinale Laghu,snigdhaLaghu,snigdha,, UshnaUshna,,

Page 21: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

COLLECTION, AUTHETIFICATION AND STANDARDIZATION

COLLECTION, AUTHETIFICATION AND STANDARDIZATION

• All ingredients in Sauwarchaladi churna and Shati churna collected.

• Sauwarchaladi churna and Shati churnaauthenticated and standardized in the Vasanti

• All ingredients in Sauwarchaladi churna and Shati churna collected.

• Sauwarchaladi churna and Shati churnaauthenticated and standardized in the Vasantiauthenticated and standardized in the VasantiDevi Pharmacy College, kodoli.authenticated and standardized in the VasantiDevi Pharmacy College, kodoli.

21

Page 22: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

MATERIAL & METHODSMATERIAL & METHODS

• Material:60 Selected patients of vataj kasa will

be collected from O.P.D of Hospital of• Material:

60 Selected patients of vataj kasa willbe collected from O.P.D of Hospital of

• Drug Preparation • Collection of source of data

be collected from O.P.D of Hospital ofYashwant Ayurvedic College & P.G.T &R.C, Kodoli, Kolhapur.be collected from O.P.D of Hospital ofYashwant Ayurvedic College & P.G.T &R.C, Kodoli, Kolhapur.

22

Page 23: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

METHODSMETHODS• 60 Selected patients will be divided equally

into Following groups• Group A (Trial group of 30 patients) -

Treated with Sauwarchaladi churna

• 60 Selected patients will be divided equally into Following groups

• Group A (Trial group of 30 patients) -Treated with Sauwarchaladi churnaTreated with Sauwarchaladi churna

• Group B (Control group of 30 patients) -Treated with Shati churnaWith Written informed consent is taken.

Treated with Sauwarchaladi churna• Group B (Control group of 30 patients) -

Treated with Shati churnaWith Written informed consent is taken.

23

Page 24: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Inclusive Exclusive criteria:Inclusive Exclusive criteria:Inclusive criteria:1. Age group between 20 to 60 years2. Sex – Male/female3. Presence of clinical features of vataj kasa

24

3. Presence of clinical features of vataj kasa4. Repeated attacks of vataj kasa

Page 25: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

•• KshayajKshayaj kasa•• KshatajKshataj kasakasa• Jara kasa• Jirna kasa

•• KshayajKshayaj kasa•• KshatajKshataj kasakasa• Jara kasa• Jirna kasa

Exclusive Criteria:Exclusive Criteria:

• Jirna kasa• Patient other than sign and symptoms of vataj

kasa• Subjects with other systemic disorders like CHD,

Diabetes, Hepato renal complications etc.• Patients on long time regular medications.

• Jirna kasa• Patient other than sign and symptoms of vataj

kasa• Subjects with other systemic disorders like CHD,

Diabetes, Hepato renal complications etc.• Patients on long time regular medications.

25

Page 26: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Group A (Trial Group) :• Drug - Sauwarchaladi churna• Matra - 3 gm daily (1.5 gm BD)• Sevankal - Apan kal

• Group A (Trial Group) :• Drug - Sauwarchaladi churna• Matra - 3 gm daily (1.5 gm BD)• Sevankal - Apan kal

Mode of Drug AdministrationMode of Drug Administration

• Sevankal - Apan kal• Anuapan - Goghrita• Duration - 28 Days

• Sevankal - Apan kal• Anuapan - Goghrita• Duration - 28 Days

26

Page 27: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Group B (Control Group) :• Drug - Shati churna• Matra - 3 gm daily (1.5 gm BD) • Sevankal - Apankal• Anuapan - Goghrita• Duration - 28 Days

• Group B (Control Group) :• Drug - Shati churna• Matra - 3 gm daily (1.5 gm BD) • Sevankal - Apankal• Anuapan - Goghrita• Duration - 28 Days• Duration - 28 Days• Duration - 28 Days

27

Page 28: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Assessment protocolAssessment protocol• Patients followed routine diet and advised to avoid

spicy, vatkar aahar.• With pathyapathya Follow up will be recorded weekly.• Study Duration: - 28 days• Follow up: - Every 7th, 14th, 21th & 28th Days

• Patients followed routine diet and advised to avoidspicy, vatkar aahar.

• With pathyapathya Follow up will be recorded weekly.• Study Duration: - 28 days• Follow up: - Every 7th, 14th, 21th & 28th Days• Follow up: - Every 7th, 14th, 21th & 28th Days• Assessment Criteria

Patients assessed initially before intervention ofmedicine and there after weekly for a period of 28 daysin the case record form, on the basis of improvement inthe Subjective & Objective parameters on various ratingscales.

• Follow up: - Every 7th, 14th, 21th & 28th Days• Assessment Criteria

Patients assessed initially before intervention ofmedicine and there after weekly for a period of 28 daysin the case record form, on the basis of improvement inthe Subjective & Objective parameters on various ratingscales. 28

Page 29: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Parameters for Subjective criteria:• Hritparshwshool ( chest pain)• Shirshool (headache)• Swarbheda (Hoarseness)• Kanth ura waktra shushkta( dryness of throat, chest, mouth)• Hristloma (horripilations)• Pratamanan ( feeling of darkness)• Nirghosh (resonant sounds)

• Parameters for Subjective criteria:• Hritparshwshool ( chest pain)• Shirshool (headache)• Swarbheda (Hoarseness)• Kanth ura waktra shushkta( dryness of throat, chest, mouth)• Hristloma (horripilations)• Pratamanan ( feeling of darkness)• Nirghosh (resonant sounds)• Nirghosh (resonant sounds)• Dainya ( anxious expression)• Stanan (loss of strength) • Daurbalya (weakness)• Shobh Mohkruta ( irritability)• Shushka kasa (dry coughing)

• Nirghosh (resonant sounds)• Dainya ( anxious expression)• Stanan (loss of strength) • Daurbalya (weakness)• Shobh Mohkruta ( irritability)• Shushka kasa (dry coughing)

29

Page 30: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Parameter for Objective criteriaChest x ray test PA view if required • Blood HB%

TLC, DLCBefore and After

treatment( Mandatory )

Parameter for Objective criteriaChest x ray test PA view if required • Blood HB%

TLC, DLCBefore and After

treatment( Mandatory )treatment( Mandatory )• ESR• AEC

treatment( Mandatory )• ESR• AEC

30

Page 31: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Criteria for Assessing the total effect :

Criteria for Assessing the total effect :

• Cured - >75% relief in signs & symptoms• Markedly improved- 51% to 75% relief in signs

& symptoms• Cured - >75% relief in signs & symptoms• Markedly improved- 51% to 75% relief in signs

& symptoms• Improved - 25% to 50% relief in signs &

symptoms• Unchanged - below 25% relief in signs &

symptoms

• Improved - 25% to 50% relief in signs & symptoms

• Unchanged - below 25% relief in signs & symptoms

31

Page 32: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Symptoms Normal(0) Mild(1) Moderate(2) Severe(3) Moresevere form(4)

Hritparshwshool( chest pain)

Nil Chest Pain Only at the time of

kasaIrrespective of kasa vega, not

affecting normal routine work

Continuous, affecting, normal

routine workSevere,

Continuous, affecting, normal

routine workShirshoola(Headache)

Nil Present occasionally, at the vega of kasa

Present frequently, with

kasaPresent

continuously irrespective of

kasa vega

Throbbing headache

continuously irrespective of

kasa vega

Basis of Gradation of Parameters

32

kasa vegaSwarbheda(Hoarsness)

Nil Irritation of throat while

speakingDifficulty in while

speakingBroken speech /voice/words

Full change speech

/voice/wordsKanthuravakrta

shushktaNil Discomfort in

throat, mouth, ura, swallowing not hampered

Dryness and irritation of

throat, swallowing in oral

cavity with difficulty

Severe itching sensation of throat, oral

cavity patient unable to swallow

More Severe itching sensation

of throat, oral cavity patient

difficult to swallow

Hristoloma(Horripilations)

Nil Bristling of hairs during kasa vega

Frequently Full bristling of hairs during kasa vega

Erection of hairs irrespective of

kasa vegaFull Erection of

hairs irrespective of kasa vega

Page 33: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Symptoms Normal(0) Mild(1) Moderate(2) Severe(3) Moresevere form(4)

Pratamanan(feeling of Drakness

Nil Feeling of darkness 2-3

times with every kasa vega

More feeling of darkness every 4-5 times of kasa

vega

Persistent feeling of Darkness every

kasa vega, 5-6 times

All time feeling of Darkness every kasa vega, 6-10

times

Nirghosh(Resonant sounds heard

during coughing)Nil Resonant sound

heard during kasa vega

More Frequent sound hears

during kasa vegaResonant sounds

are heard irrespective of

kasa vega

Visibly Resonant sounds are heard

irrespective of kasa vega

Dainya(anxious expressions)

Nil Half smile and slight widening of eyes anxious look

Slightly smile and feeling of tension

on faceFull tensed no

smile expressionOn face

Visiblytensed no smile

expression

33

Stanan( loss of strength)

Nil Mild movement all body parts

against resistance during kasa vega

More resistant of all movement of

body parts during kasa vega

More resistance against gravity,

resistance irrespective of

kasa vega

Greaterresistance against

gravity, resistance

irrespective of kasa vega, less

activeDaurbalya

(Weakness)Nil Occasionally

feeling of weakness during

kasa vega

Frequent more feeling of

weakness during kasa vega

Total feeling of Weakness

irrespective of kasa vega

Generalisedfeeling of Weakness

irrespective of kasa vega

Kshobhmohkrita( Irritability and fainting)

Nil Present irritability during kasa vega

Frequently irritable while

kasa vegaIrritable

irrespective of kasa vega

Highly Irritable irrespective of

kasa vega

Page 34: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

OBSERVATION AND RESULTS OBSERVATION AND RESULTS

• Clinical efficacy of treatment will be observed and recorded result willbe drawn using statistical analysis of data.

• The effect on the various signs and symptoms recorded. Aim of thisclinical trial is clinical assessment of Sauvarchaladi churna in vatajkasa. For statistical analysis, Wilcoxon Signed Ranks test, Mann-

• Clinical efficacy of treatment will be observed and recorded result willbe drawn using statistical analysis of data.

• The effect on the various signs and symptoms recorded. Aim of thisclinical trial is clinical assessment of Sauvarchaladi churna in vatajkasa. For statistical analysis, Wilcoxon Signed Ranks test, Mann-kasa. For statistical analysis, Wilcoxon Signed Ranks test, Mann-Whitney U test is used.

• The Wilcoxon signed-rank test, Mann-Whitney U test is a non-parametric statistical hypothesis tests, which can be used as analternative to the paired Student's t-test, t-test for matched pairs, orthe t-test for dependent samples when the population cannot beassumed to be normally distributed

kasa. For statistical analysis, Wilcoxon Signed Ranks test, Mann-Whitney U test is used.

• The Wilcoxon signed-rank test, Mann-Whitney U test is a non-parametric statistical hypothesis tests, which can be used as analternative to the paired Student's t-test, t-test for matched pairs, orthe t-test for dependent samples when the population cannot beassumed to be normally distributed

34

Page 35: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Overall resultOverall result

60%

80%

100%

120%

Axis T

itle

Overall Analyses on subjective Parameters

35

Hritparshwashool Shirshool Swarabhe

dakanthurav

aktra shushkata

Hristloma Pratamanan Nirghosh Dainya Stanan Daurbalya Kshobhm

ohkrutaShushk

kasaTrial Group 93% 94% 92.98% 90% 94% 94% 94% 88% 85% 86% 89.70% 88.70%Control Group 81% 96% 72% 80% 76% 80% 79% 79% 71% 68.90% 82.70% 70%

0%

20%

40%

60%

Axis T

itle

Page 36: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Group

Result of therapy(No. of parameters improved)

(%)No relief

(0-3)(0%-25%)

Mild Relief(4-6)

(25%-50%)

Moderate relief(7-9)

(50%-75%)

Total relief(10-12)

(75%-100%)

MATHEMATICS AND NUMBERS

36

Count % Count % Count % Count %

No.of

Patients

Trial Group 3 10.00

%2 6.67% 2 6.67% 23 76.67%

Control Group 3 10.00

%9 30.00% 11 36.66% 7 23.33%

Page 37: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Sr.no. Signs & Symptoms Median Relief in % P- Value T+BT AT

1. Hritparshwshool 2 0 93%↑ <0.01 4652. Shirshool 2 0 94%↑ <0.01 4653. Swarbheda 2 0 92.98%↑ <0.01 4654. Kanthurvaktrashushkata 2 0 90%↑ <0.01 4355. Hristloma 2 0 94%↑ <0.01 4356. Pratamanan 2 0 90%↑ >0.01 4357. Nirghosh 2 0 94%↑ <0.01 4658. Dainya 2 0 88%↑ <0.01 4659. Stanana 2 0 85%↑ <0.01 40610. Daurbalya 2 0 86%↑ <0.01 40611. Kshobhmohkruta 2 0 89.7%↑ <0.01 435

Statistics in Trial Drug Group

37

12. Shushkkasa 2 0 88.7%↑ <0.01 43513. Hb% Mean

5.96% <0.001T Value

10.340 10.957 -5.07214. Total leucocyte count 10000 5000 44.95% <0.001 37815. Differential

leucocyteCount

DLC Median difference Total Relief % P- value T+

N 10

45.09%

0.079% -L 5.5 0.517% -E 1 0.094% -B 0 0.198% -M 0 0.002% -

16. Erythrocyte sedimentation count 10 1↓ 75%↑ <0.001 406

17. Absolute Eosinophil count 10 1↓ 17.55%↑ <0.001 406BT- before Treatment, AT- after Treatment, %- Percentage, P- value- Probability value, T+ Value- Wicoxon signed rank

Page 38: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Relief GraphRelief Graph22 93 3

50%60%70%80%90%

100%

38

23

7

11

0%10%20%30%40%50%

Trial Group Control GroupTotal relief Moderate Relief Mild relief No relief

Page 39: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Overall analyses on Objective Parameters Overall analyses on Objective Parameters Sr. No. Objective

ParametersImprovement %

Trial Group Control Group

1 HB% 5.96% 4.86%2 TLC 44.95% 35.8%2 TLC 44.95% 35.8%3 DLC (average) 35.64% 45.09%4 ESR 75% 58%5 AEC 17.22% 11.88%

39

Page 40: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Sr.no. Signs & Symptoms Mann Whitney (U ) Normal approx. (Z) P- ValueBT AT BT AT BT AT

1. Hritparshwshool 949.5 795↓ 0.556 -2.226 0.578 0.0262. Shirshool 1000 949↓ 1.349 0.839↓ 0.178 0.4013. Swarbheda 866 717↓ -0.755 -3.711 0.45 0.00024. Kanthurvaktrashushkata 837 813↓ -1.218 -1.981 0.223 0.00755. Hristloma 878.5 778.5↓↓ -0.578 -2.674 0.563 0.00756. Pratamanan 869.5 807↓ -0.73 -2.218 0.465 0.0277. Nirghosh 882.5 793.5↓ -0.573 -2.436 0.608 0.01158. Dainya 921 825↓ 0.087 -0.667 0.931 0.0969. Stanana 888.5 788↓ -0.461 -2.221 0.645 0.02610. Daurbalya 858.5 783↓ -0.907 -2.258 0.364 0.024

Statastics on symptoms, signs and hematological parameters of Vataj Kasa in Trial Group

40

11. Kshobhmohkruta 984 870↓ 1.078 -0.877 0.281 0.38012. Shushkkasa 881.5 774↓ 0.535 2.494 0. 592 0.01313. Hb% t df

0.0219 0.289↓-1.241 -1.069↑ 5814. Total leucocyte count( TLC) 1028.5 877↓ 1.651 -0.580 0.099 0.562

DifferentialLeucocyteCount(DLC)

N 1003 1.756 0.079L 928.5 0.649 0.517E 991.5 1.679 0.0094B 868.5 -1.288 0.198M 1058 3.166 0.002

16. Erythrocyte sedimentation count 8 7↓ 40% <0.00517. Absolute Eosinophil count 928.5 759.5↓ 0.149↓ -2.398 0.882 0.017

BT- Before Treatment, AT- After Treatmment, Value got after applying Mann Whitney (U ) Factor, Normal approximation (Z), P- value- Probablity value, t- Value got after applying T - Test

Page 41: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Aggravating FactorAggravating FactorAggravating Factors Trial Group Control Group Total

Present In % Absent In % Present In % Absent In % In %

Dust 17 56.66 13 43.34 19 63.33 11 36.67 60

Food 8 26.66 22 73.34 10 33.33 20 66.67 30

Smoke 7 23.33 23 76.67 6 20 24 80 21.66

Animal 8 26.66 22 73.34 1 3.33 29 96.67 15

41

Pollen 4 13.33 26 86.67 2 10 28 90 10Cosmetics 4 13.33 26 86.67 0 0 30 100 6.66

Drugs 8 26.66 22 73.34 2 10 28 90 16.66

Climate 7 23.33 23 76.67 7 23.33 23 76.67 23.33

Sheetahar 6 20 24 80 10 33.33 20 66.67 26.66

Page 42: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Dust, 60%Drugs, 16.66%

Animal, 15%Pollen, 10%

Cosmetics, 6.66%Overall Incidence of Aggravating factors

42

Food, 30%

Sheetahar, 26%

Climate, 23.30%

Smoke, 22%

Page 43: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Comparative Analysis AEC in Groups

GroupAbsolute

Eosinophils Count(AEC)

Median Sample sizeMann-

WhitneyU statistic

Normal approximati

on‘Z’

P- Value

Trial GroupBefore

Treatment 515 30 925.5 0.149 0.882

43

Trial Group After Treatment 400 30 759.5 -2.398 0.017

Control Group

Before Treatment 515 30 925.5 0.149 0.882

After Treatment 450 30 759.5 -2.398 0.017

Decrease-

Page 44: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

0200400600

Trial Group Control Group

515 515400 450

AEC

Groups

AEC (median)Before treatmentAfter treatment

Sr. No. Objective Improvement %

44

Sr. No. Objective Parameters

Improvement %Trial Group Control Group

1 HB% 5.96% 4.86%2 TLC 44.95% 35.8%3 DLC (average) 35.64% 45.09%4 ESR 75% 58%5 AEC 17.22% 11.88%

Page 45: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

DISCUSSION AND SUMMARY DISCUSSION AND SUMMARY • In order to achieve this aim the study has been

divided into 3 parts• Discussion on conceptual literary study of disease.• Discussion on mode of action of drug of

• In order to achieve this aim the study has been divided into 3 parts

• Discussion on conceptual literary study of disease.• Discussion on mode of action of drug of

45

• Discussion on mode of action of drug of Intervention.

• Discussion on the observation and results of clinical study.

• Discussion on mode of action of drug of Intervention.

• Discussion on the observation and results of clinical study.

Page 46: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Probable mode of drug actionProbable mode of drug action• Srotas vitiated is Pranavaha srotas, which is corrected

by all the drugs, as they have kasa hara and swasa haraproperties. Srotodusti is sanga, which is relieved byushna veerya and srotoshodaka properties of the drugs.Principle of Vaatanloman, strotovishodhan is main

• Srotas vitiated is Pranavaha srotas, which is correctedby all the drugs, as they have kasa hara and swasa haraproperties. Srotodusti is sanga, which is relieved byushna veerya and srotoshodaka properties of the drugs.Principle of Vaatanloman, strotovishodhan is mainPrinciple of Vaatanloman, strotovishodhan is maincriteria in samprapti vightana of Vataj kasa.Principle of Vaatanloman, strotovishodhan is maincriteria in samprapti vightana of Vataj kasa.

46

Page 47: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Sl. no Drugs Name

Ras, ViryaVipaka

Guna Karma Pharmacological property1. Sauvarchal lavan

ChurnaLavanUshnaAmla

Ladhu,Vishad,Suksma

Deepan, Pachan,Rochan,

VatanulomanAntihistaminic, Natural

hypnotic, Electrolyte supplier

2. Yawakshara KatuUshna Katu

Laghu,Snigda

Deepan,Shwasahara

Galarogahara

Diuretic, Corrosive,

3. Haritaki Panch-ras-kasayUshna Madhur

Laghu,Ruksh Vaat kaphhara,Deepan, Pachan,

Shothhar,Vatanuloman

Antifungal -Antimicrobial, Antispasmodic, Antihistaminic,

Antinflammatory

4. Amalaki Panch-ras-amlasheet Madhur

Guru,Ruksh,Sheet

TridoshharDeepan, Pachan,

Rochak,Antitussive, Antioxident,

Immunomodulator, Tonic, CNS protective, Anti skin infective

47

Sheet Rochak,Vatanuloman,

protective, Anti skin infective agent, Diuretic, Bile stimulant,

digestives.5. Pippali katu

Anu-UshnasheetMadhur

Laghu,SnigdaTiksna

Vaat kaphhara,Deepan,

Shool harVatanuloman,

Kasar

Antibacterial, Antiinflammatory,

Bronchodilator, expectorant, Antiasthmatic ,

CNS stimulant anthelmintic.6. Shunthi Katu

UshnaMadhur

Laghu,Snigda

Vaatkaphhara

Deepan, Pachan,Vatanuloman,

analgesic, antidypsetic, Anti-inflammatory, Anti-allergic,

Antioxidant agent & cholagogue

Page 48: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Samrapti vighatana in Vataj KasaSamrapti vighatana in Vataj Kasa

48

Page 49: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

ConclusionConclusion

• Conclusion On Conceptual study• Conclusion On Clinical study• Conclusion On Conceptual study• Conclusion On Clinical study

Page 50: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Conclusion On Conceptual study• Literal study of Charkokta kasa chikitsa addhay is mentioned that kasa

is ashukari.• Acharya charak mentioned Firstly treat Vataj kasa. If left

untreated it’s a kshayprada.• According to Acharya charak, pratighat vishesh vaat dosha is

responsible for samprapti of kasa.• Acharya charak mentioned Dhoom yoga like Manashiladi dhuma, leha

Conclusion On Conceptual study• Literal study of Charkokta kasa chikitsa addhay is mentioned that kasa

is ashukari.• Acharya charak mentioned Firstly treat Vataj kasa. If left

untreated it’s a kshayprada.• According to Acharya charak, pratighat vishesh vaat dosha is

responsible for samprapti of kasa.• Acharya charak mentioned Dhoom yoga like Manashiladi dhuma, leha• Acharya charak mentioned Dhoom yoga like Manashiladi dhuma, leha

yoga, Pippalyadi leha, also mentioned Mutra vivarnata chikitsa inkshayaj kasa.

• Acharya charak described Vividh kalpana for kasa vyadhi likeBhojya, paan, peya, grita, leha, panak, kshir, sarpiguda,dhoompaana called as Kasbhaishajya sangraha.

• From the drug review, Sauvarchaladi churna includes drugs whichpossess qualities like, Ushna, Snigdha, Vaatanulomak andvaatkaphaghna, hence effective in management of Vataj kasa.

• Acharya charak mentioned Dhoom yoga like Manashiladi dhuma, lehayoga, Pippalyadi leha, also mentioned Mutra vivarnata chikitsa inkshayaj kasa.

• Acharya charak described Vividh kalpana for kasa vyadhi likeBhojya, paan, peya, grita, leha, panak, kshir, sarpiguda,dhoompaana called as Kasbhaishajya sangraha.

• From the drug review, Sauvarchaladi churna includes drugs whichpossess qualities like, Ushna, Snigdha, Vaatanulomak andvaatkaphaghna, hence effective in management of Vataj kasa.

Page 51: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Conclusion On Clinical study• The age group indicates that the highest incidence of vataj kasa is in the age

group of 20-30 yrs• The majority of patients were from middle class.• Maximum patients who had greater exposure to strenuous work Majority of

Farmers.• In this study reveals maximum numbers of patients were Vata kapha

prakruti.• The Patients reveals that the majority of patients had Mandagni.

• Conclusion On Clinical study• The age group indicates that the highest incidence of vataj kasa is in the age

group of 20-30 yrs• The majority of patients were from middle class.• Maximum patients who had greater exposure to strenuous work Majority of

Farmers.• In this study reveals maximum numbers of patients were Vata kapha

prakruti.• The Patients reveals that the majority of patients had Mandagni.• The Patients reveals that the majority of patients had Mandagni.• Aggravating factors showed 3 main causes for Vataj kasa, and by that it can

be concluded that majority of Dust, food and climate.• Constipatated bowel habit having an influence on Vataj kasa.• Hritparshwashool (chest pain), Shirshool (head ache), swarabheda, leads to

the conclusion that, Sauvarchaladi churna is more effective than Shatichurna in fully relief in hritparshwashool when taken orally.

• The Patients reveals that the majority of patients had Mandagni.• Aggravating factors showed 3 main causes for Vataj kasa, and by that it can

be concluded that majority of Dust, food and climate.• Constipatated bowel habit having an influence on Vataj kasa.• Hritparshwashool (chest pain), Shirshool (head ache), swarabheda, leads to

the conclusion that, Sauvarchaladi churna is more effective than Shatichurna in fully relief in hritparshwashool when taken orally.

Page 52: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Sauvarchaladi churna is having significant benefit over Shati churna in reducing kanthuravaktra shushkta, hristloma (Horripilations), pratamanan(feeling of darkness), nirghosh (Resonant sounds heard during coughing) in Vataj kasa.

• Sauvarchaladi churna is preferable than only following orally Shatichurna in fully relief in nirghosh. dainya (anxious expression), stanan(loss of strength), daurbalya (weakness) in Vataj kasa.

• Sauvarchaladi churna is having considerable benefit over Shati churna in reducing kshobhmohkruta (Irritability and fainting), daurbalya (weakness) shushk kasa (dry coughing) in Vataj kasa.

• Sauvarchaladi churna is having significant benefit over Shati churna in reducing kanthuravaktra shushkta, hristloma (Horripilations), pratamanan(feeling of darkness), nirghosh (Resonant sounds heard during coughing) in Vataj kasa.

• Sauvarchaladi churna is preferable than only following orally Shatichurna in fully relief in nirghosh. dainya (anxious expression), stanan(loss of strength), daurbalya (weakness) in Vataj kasa.

• Sauvarchaladi churna is having considerable benefit over Shati churna in reducing kshobhmohkruta (Irritability and fainting), daurbalya (weakness) shushk kasa (dry coughing) in Vataj kasa.shushk kasa (dry coughing) in Vataj kasa.

• Sauvarchaladi churna is significantly beneficial in reducing DLC and AEC than Shati churna alone.

• Sauvarchaladi churna do samprapti vightana on the basis of Guna karma siddhant, hence its exact role is proven by stastistically and clinically

• All the results of the individual parameters and overallassessment, it can be concluded that the Sauvarchaladi churna issignificantly better than Shati Churna alone. It validates Kasahar and antallergic property in Vataj kasa.

shushk kasa (dry coughing) in Vataj kasa.• Sauvarchaladi churna is significantly beneficial in reducing DLC and

AEC than Shati churna alone.• Sauvarchaladi churna do samprapti vightana on the basis of Guna karma

siddhant, hence its exact role is proven by stastistically and clinically• All the results of the individual parameters and overall

assessment, it can be concluded that the Sauvarchaladi churna issignificantly better than Shati Churna alone. It validates Kasahar and antallergic property in Vataj kasa.

52

Page 53: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

• Sauvarchaladi churna do samprapti vightana on the basis of Gunakarma siddhant, it also revealed by clinical study and statisticalanalysis.

• It’s Easy to use Sauvarchaladi churna for treatment of Vataj kasa,patient easily treated due to palatability than Shati churna.

• From the present clinical trial, It can be concluded that Sauvarchaladichurna effectively do the samprapti vighatana of Vataj kasa asmentioned in classical texts.

• Further study is needed with larger sample size for better establishment

• Sauvarchaladi churna do samprapti vightana on the basis of Gunakarma siddhant, it also revealed by clinical study and statisticalanalysis.

• It’s Easy to use Sauvarchaladi churna for treatment of Vataj kasa,patient easily treated due to palatability than Shati churna.

• From the present clinical trial, It can be concluded that Sauvarchaladichurna effectively do the samprapti vighatana of Vataj kasa asmentioned in classical texts.

• Further study is needed with larger sample size for better establishment • Further study is needed with larger sample size for better establishment of efficacy of Sauvarchaladi churna.

• Further study is needed with larger sample size for better establishment of efficacy of Sauvarchaladi churna.

53

Page 54: Dr.Bhushan D. Mhaiskar CLINICAL ASSESSMENT OF SAUVARCHALADI CHURNA IN VATAJ KASA

Thanking you

54