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Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

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Learn more about the Brazilian project that won silver medal in the 2014 iGEM synthetic biology in Boston / USA. A partnership between C.E.S.A.R and LIKA-UFPE.

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Page 1: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 2: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

A private institute that innovates in products, services and

companies with Information and Communication

Technologies (ICTs). Since its foundation in1996, the

center helps companies throughout the innovation life

cycle - from the study of contexts, design and prototyping

ideas, to developing solutions in various sectors.

Page 3: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

Our mission is to perform self sustainable transfer of knowledge in Information Technologies between society and academia

society academia

Page 4: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

design

studies & research

prototyping & evaluation development commercialization

C.E.S.A.R COMPANIES

setup

Page 5: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

Services

Finanças

Telecom

Government

Electronic Industry

Energy

3º Sector

Page 6: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 7: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

SolutionsINNOVATIVE

COMPLEXProblems

Page 8: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

Population aging combined with

increased awareness about

health have generated a greater

need for regular medical care,

which has significantly raised the

costs of the healthcare industry

in the world.

Page 9: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

The treatment of

diseases is usually

performed in a

reactive way, so when

the disease is

diagnosed it is often

in an advanced stage

of development.

PATIENT DOCTOR LABORATORY

RESULTSDOCTORTREATMENT

Page 10: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

Molecular diagnosis currently makes it

easy to detect primary diseases with high

specificity and sensitivity. However,

techniques are expensive, requiring much

time and skilled and trained personnel.

Ionn Torrent: state-of-the-art DNA sequencer. It performs human genome sequencing to estimate the risk of cancer or other genetic diseases.

Biosensors come up as a portable

alternative, cheaper and simpler to handle

while maintaining the same sensitivity and

specificity of molecular diagnosis.PCR Machine: performs real-time analysis of patient samples (cancer, viral and bacterial diseases, etc..)

Page 11: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 12: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

We believe that the use of biosensors for early detection and

diagnosis of diseases can increase the chances of patient

survival and reduce the costs of medical care compared to

reactive treatments in very advanced stages of diseases.

Page 13: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

But there are still limitations of use

which prevent the unrestricted

application of biosensors by the

healthcare industry. To spread the

use of this technology, it is

necessary to develop more efficient,

reliable and user friendly systems.

Page 14: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 15: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

Laboratory of Immunopathology Keizo Asami (LIKA), founded in 1986, has several research areas. Among them, there are the diagnosis and the proposition of new therapeutic procedures. LIKA is engaged in developing strategies to increase resolution for diagnosis of genetic diseases, infectious agents, acquired and autoimmune diseases.

[http://www.ufpe.br/lika/ ]

Page 16: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 17: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

Bringing together LIKA's scientific experience with C.E.S.A.R.'s

technological skills, to develop biosensors for the detection of

breast cancer with the help of robotics.

The idea is to build a system which is able to process and prepare

small blood samples in an automated fashion. This system will be

coupled with biosensors that are capable of detecting breast

cancer in its early stages.

The goal is to shorten the analysis of samples from patients that

currently take 4-6 hours to less than 30 minutes.

Page 18: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

http://2014.igem.org/Giant_Jamboree

The first milestone of this

partnership was the presentation

of this project at the iGEM

competition, at the event Giant

Jamboree on Nov/14 in Boston.

The event gathered more than

3000 participants during 5 days

of lectures and project

presentations. The LIKA-CESAR-

BRASIL team won a silver medal

at the competition.

Page 19: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

The iGEM Competition 2014 is a

competition created by MIT for the

advancement of synthetic biology

through a worldwide competition

where teams develop their studies in

the construction of biological

systems to be operated in living cells.

http://igem.org/

Page 20: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 21: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership
Page 22: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

● Bring together a multidisciplinary team of researchers

● Create a network of complementary institutions

● Launch the LIKA.CESAR lab

● Explore the potential of biosensors in fields (agribusiness)

Page 23: Biosensor for Early Detection of Breast Cancer - LIKA-CESAR Partnership

http://youtu.be/2V-yEJHLosk