Embed Size (px)
DESCRIPTION
B4 the code for uor Liposomal Hyaluronic Acid, biological performance has been tested to check increased bioavailability. our product outperform the regular HA in water solution. Get the most of HA by using Hidramize Hyaluronic Acid by Lipomize.
Citation preview
HidraMize® LIPOSOMALHYALURONIC ACIDLow Molecular Weight
HidraMize® HyALURONIC ACID
LIPOSOMAL TECHNOLOGY ADVANTAGES
BENEfITS Of HYALurONIC ACID
Short molecule
of ha. PDB CoDe: 2BVK
HIDrAMIzE® HYALurONIC ACID LIPOSOME
Liposomes are nanosized spheres of lipid bilayers, its size is less than one thousandth of a millimeter. They are composed entirely by natural biocompatible molecules, which have the ability to transport active ingredients within or on its membrane, releasing the active compo-nent in a gradual and controlled way providing greater bioavailability, protection and long lasting effect.
Liposomes increase bioavailability, this means that a greater amount of the active ingredient fulfills its spe-cific effect. higher performance can be achieved even lowering dosing.
Liposomes exert their influence in the stratum cor-neum of the skin improving penetration of the active;
this property turns liposomes particularly effective for cosmetic use.
all the moisturizing and restorative properties of the low molecular weight hyaluronic acid are improved by Lipomize’s liposome.
ExclusivE advantagEsFunctional properties are delivered where they are
most needed.hyaluronic acid is protected and transported within
our premium line of Hidramize® liposomes.Delivery System protects the active ingredient, more
intact hyaluronic acid reachs target cells to nourish.
hyaluronic acid (ha) is a linear polysaccharide of high molecu-lar weight, naturally occurring in the human body. It changes the physical properties of the epider-mis, especially due to its ability to immobilize a large volume of water in its structures, and is also active in relation to improve intercellular communication. It is applied as a connective tissue organizer and hydrating substance on the basis of its status as the most hydrated poly-mer known. Since it is a naturally occurring substance, ha is free of immunogenic activity, and is a non-toxic and non-irritating substance.
ha’s basic mechanism of action is the improved barrier function of the
stratum corneum. ha low molecular weight is able to penetrate into the deep layers of the stratum corneum, where it operates on several levels.
First, it has the capacity to protect phospholipids against peroxidation by uV and free radicals. These phos-pholipids are part of the natural moisturizing factor (nmF), the pres-ence of which is essential for the proper barrier function of the skin.
Secondly, ha has a positive effect on the activity of betaglucocerebro-sidase, an enzyme responsible for the release of ceramides from their glucosyl precursors. Ceramides are then incorporated into the lipid bilayer of corneocytes, and the nmF function is enhanced.
The last positive mechanism is the natural ability of hyaluronic acid to immobilize a large quantity of water in its structures, which helps to restore proper nmF functioning in the epidermis.
Liposomes assembled by Lipomize are formulated with natural phospholipids extracted from soy lecithin. Low energy methods are used for processing, protecting the integrity and stability of the nanovesicles and ha. Lipomize has availability of best raw materials for its homogeneous size controlled lamellarity liposomes, natural soy lecithin and low molecular weight ha. hidramize liposomes possess high resistance to the action of surfactants and high structural and physico-chemical stability, fulfilling its function of nanometric
carrier. They also have essential components for cell metabolism. Particularly provide a high concentration of linoleic acid (vitamin F) precursor of Ceramide1, fun-damental component of the Natural Moisturizing Factor, being liposomes an excellent moisturizer by them-selves. all properties of hyaluronic acid are enhanced by the implementation of a delivery system which enables controlled release allowing long lasting effect and letting hyaluronic acid reach the deeper layers of the skin intact.
ParticlE sizE distribution
Dynamic Light Scattering. hydramize Liposome have narrow size distribution and average size of 180 nm.
atomic ForcE microscoPy. Laboratorio de Superficies e Interfases. Instituto de Desarrollo Tecnológico para la Industria Química, intec (conicet-unl). Güemes 3450 (s3000gln), Santa Fe, argentina
HidraMize® HyALURONIC ACID
BIOLOGICAL PErfOrMANCE Of LIPOSOMAL HYALurONIC ACID HIDrAMIzE®
fOrMuLATION PErfOrMANCE Of LIPOSOMAL HYALurONIC ACID HIDrAMIzE®
SuGGESTED CLAIMS
Support epidermal hydration by improving intercellular com-munication
Higher bioavailability of liposo-mal Hyaluronic Acid
Liposome / Nanotechnology Deeper Moisturizing Effect Oxidative Stress reducer Hydration improvement by affect-
ing the skin’s epidermal structure
Superb moisturizing Effect Antiaging / Antiwrinkle Sustained release system for long
lasting effect Higher Skin smoother Properties
Hydration PErFormancE
Measured by Thermography. (www.aboutclaim.com). Liposomal hyaluronic acid has higher hydration performance versus non liposomal hyaluronate.
sustainEd rElEasE
Liposome keep hyaluronate at high levels for up to 5 hours ensuring long lasting effect.
tEmPEraturE rEsistancE
hidramize Liposome’s phospholipids blend ensure temperature resistance up to 60°C with no modification in its membrane properties.
surFactants rEsistancE
hidramize Liposome are made with a proprietary blend of natural phospholipids that ensure surfactant resistance in most cosmetics formulations.
LIPOSOMAL HA 0.05%35 years old volunteer
NON LIPOSOMAL HA 0.05%35 years old volunteer
T = Day 0 T = Day 0
T = Day 28 T = Day 28
1. Skin hydration % using Hidramize B4 for 28 days
2. Skin hydration % in normal conditions
1. 2.
PRODUCT SPECIFICATION
NAME: Liposomal Hyaluronic Acid 0,5 %. Puri�ed Phospholipids from Non-GMO Soy Lecithin.
APPEARANCE: whitish homogene-ous liquid without precipitates slightly opalescent.
ODOR: slightly alcoholic without traces of rancidity.
PHYSICOCHEMICAL PROPERTIESParameterDensityViscositypHAcidityPeroxidesAverage particle sizeConcentration of Liposome
Minimum1.00412 cP6,55 %5 meq/100 mL110 nm6.25 x 1015 Liposome/L
Maximum1.01318 cP8,0Tritrable
250 nm
Comments
Ostwald MethodDirect
DLSEstimated from phospholipids concentration and particle size
PROXIMATE ANALYSISComponentHyaluronic AcidTotal PhospholipidsPhosphatidilcholinePhosphatidilethanolaminePhosphatidil InositolPhosphatic AcidEthanol
CommentsHPLCHPLCHPLC (% of total phospholipids)HPLC (% of total phospholipids)HPLC (% of total phospholipids)HPLC (% of total phospholipids)
MICROBIOLOGYEnterobacter S. AureusYeast & MoldsTotal Plaque Count
PACKAGINGAvailable in 1 L, 5 L & 25 L. Other sizes upon request.
0/g0/g50/g100/g
TOXICOLOGYNon-irritating. Hypoallergenic. Non-cytotoxic.
Recommended use level: 5–10 %Incorporation: For cold processes, dissolve
Hidramize B4 into the aqueous phase. In cold/hot processes, add during the cooling phase below 40 °C.
Thermostability: Temperatures of up to 60 °C for a short time do not a�ect the stability of Hidramize B4.
Stable with glycolic acid and at acidic pH (3.5)Sensitive to heat and extreme pH values.
Stability increases with decreasing molecular weight. Very sensitive to free radicals.
Incompatible with cationic substances, e.g. quarternized polymers and proteins (Quarterniums, Polyquarterniums, etc.).
CODE: B-4
FORMULATING WITH HIDRAMIZE B4
MARKETING BENEFITS
Curb premature face wrinkling.Boost skin elasticity Promote �rm skin tone.Enhance collagen synthesis.Nourish healthy skin cell growth.
APPLICATIONS Gel eye make-up remover.Antiwrinkle anti-stress serum.Nourishing moisturizing cream.Lipstick with hyaluronic acid.Moisturizing pre-sun after-sun milks.Pre-shaves/After shaves.
Aqua | Phospholipids | Hyaluronic AcidINCI NAME
CONTACT INFORMATION OF DISTRIBUTORS
ARGENTINE:Kromberg Fine Chemicals SRL Calle Septiembre 151, Escobar. Parque industrial Hijo del Dueño Phone: +54 348 442-7005 [email protected] www.kromberg.com.ar
BRAZIL: Savixx Comércio Internacional S/A Av. Ibirapuera, 2.332, Bloco II conjunto 51. Moema, São Paulo, SP, CEP 04088-002 Phone: 11 5053-9650 Fax: 11 5053-9670 [email protected] www.savixx.com.br
PERU (COLOMBIA/ECUADOR): Al�l Andina S.A.C Av. Las Artes Norte 855. San Borja, Lima 41, Peru Phone: +51 1 207 0730 oscar@al�landina.com www.al�landina.com
CHINAJoyvo New Material Co., LtdNo.35 Dingxing Road, Food Industrial Zone. Yangzhou, Jiangsu, 225004, P.R. ChinaPhone: +86 514 8581 [email protected]
Lipomize SRL. Ruta 168, Paraje El Pozo. Parque Tecnológico Litoral Centro, Laboratorio 11. Santa Fe, Santa Fe, Argentina. Zip Code: 3000 Phone: +54 342 4511 546 ext 1516. Fax: +54 342 4511 547 ext [email protected] | www.lipomize.com
© Copyright. LIPOMIZE SRL Argentina. All rights reserved.
Minimum0,50 %10 mM41 %10 %0 %41 %10 %
Maximum0,53 %15 mM48 % 15 %1 % 44 %
