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Computer-Aided Diagnosis System for Ground-Glass Opacity
using MDCT ImagesJin Sung Kim, MS*, Jin-Hwan Kim, MD**, G. Cho, PhD*
Korea Advanced Institute of Science and Technology, Daejeon, Korea*, Department of Radiology, Chungnam National University Hospital, Daejeon, Korea**
2005 33th Korea Society of Medical & Biological Engineering, KINTEX
Contents
• Introduction– What is CAD?– What is Ground Glass Opacity?– Previous GGO CAD algorithm– Purpose & Idea
• Methods– Concept overview– 3DMM algorithm– GGO Enhanced Image– Support Vector Machine
• Results• Conclusion
Contents
• Introduction– What is CAD?– What is Ground Glass Opacity?– Previous GGO CAD algorithm– Purpose & Idea
• Methods– Concept overview– 3DMM algorithm– GGO Enhanced Image– Support Vector Machine
• Results• Conclusion
What is CAD?
• What is CAD?– Computer-Aided Diagnosis– Computer-Aided Detection Second opinion
• Purpose of CAD– Improvement of diagnostic accuracy– Consistency of image interpretation
• CAD Application– Breast, Lung nodule, Polyp etc…
Introduction1. What is CAD?2. What is GGO?3. Previous GGO CAD4. Purpose & Idea
Ground Glass OpacityIntroduction
I-ELCAP defined "ground-glass opacity" as a CT finding of a partially-opaque region that does not obscure the structures contained within (e.g. vessels).
1. What is CAD?2. What is GGO?3. Previous GGO CAD4. Purpose & Idea
Previous GGO CAD
• Kim KG, Goo JM, Kim JH, Lee HJ, Min BG, Bae KT, Im JG.Computer-aided diagnosis of localized ground-glass opacity in the lung at CT: initial experience. Radiology. 2005 Nov;237(2):657-61.
• Uchiyama Y, Katsuragawa S, Abe H, Shiraishi J, Li F, Li Q, Zhang CT, Suzuki K, Doi K. Quantitative computerized analysis of diffuse lung disease in high-resolution computed tomography. Med Phys. 2003 Sep;30(9):2440
• Kauczor HU, Heitmann K, Heussel CP, Marwede D, Uthmann T, etc Automatic detection and quantification of ground-glass opacities on high-resolution CT using multiple neural networks: comparison with a density mask. Am J Roentgenol. 2000 Nov;175(5):1329-34.
• International Conference (SPIE, RSNA, CARS)
Introduction1. What is CAD?2. What is GGO?3. Previous GGO CAD4. Purpose & Idea
Purpose & Idea
• Previous GGO CAD research groups used– General 2D slice CT image & Texture only– Neural Networks (MLP)
• Our GGO algorithm proposes– Using 3D information with 3DMM algorithm – GGO Enhanced Image– Support Vector Machine
Introduction1. What is CAD?2. What is GGO?3. Previous GGO CAD4. Purpose & Idea
Contents
• Introduction– What is CAD?– What is Ground Glass Opacity?– Previous GGO CAD algorithm– Purpose & Idea
• Methods– Concept overview– 3DMM algorithm– GGO Enhanced Image– Support Vector Machine
• Results• Conclusion
Concept of GGO CAD
Air Component
Soft TissuePulmonary VesselSolid nodules
GGO nodules
CT Noises
After soft tissue & air component extraction, GGO detection is more easier !!!!.
Methods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
Overall AlgorithmMethods1. Concept overview
2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
3DMM Algorithm
• We proposed computer aided diagnosis (CAD) system for detection of solid pulmonary nodules using 3D morphological matching algorithm (3DMM) that takes advantage of 3D volumetric data.
• After 2D slice segmentation, extraction of pulmonary vessel is performed for isolated solid nodule detection.
“Pulmonary nodules: automated detection on CT images with morphologic matching algorithm--preliminary results”, Bae KT, Kim JS, Na YH, Kim KG, Kim JH, Radiology. 2005 Jul;236(1):286-93. “Automated detection of pulmonary nodules on CT images: effect of section thickness and reconstruction interval--initial results”, Kim JS, Kim JH, Cho G, Bae KT, Radiology. 2005 Jul;236(1):295-9.
Methods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
SegmentationMethods1. Concept overview
2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
Vessel Extraction
3D image of segmented lung volume 3D image of extracted pulmonary vessel using 3D region-growing method
After vessel subtraction, 3D shape feature (volume, size, compactness, and elongation factor) were applied to non-vessel structure
from “Pulmonary nodules: automated detection on CT images with morphologic matching algorithm--preliminary results”, Bae KT, Kim JS, Na YH, Kim KG, Kim JH, Radiology. 2005 Jul;236(1):286-93.
Methods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
Original 2D Image Extracted Vessels
We can find a GGO in right lung region The GGO was not included in vessel
Methods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
GGO Enhanced ImageDetected Image using
thresholding technique
Original CT Image – Soft Tissue Image Using thresholding, GGO can be found
Methods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
Support Vector Machine• It is general that SVM shows better performance than
other Neural Network (MLP, etc…) in binary classification.
• OSU LIBSVM in MATLAB• Two independent set (total 29 cases)
– Training set(16), Test set(13)
• 10 input parameters• Kernel Type
– Polynomial, degree: 3
Materials & MethodsMethods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
Texture analysis
• 32x32 matrix
• Texture– Mean
– Standard deviation
– Skewness
– Kurtosis
– Area
– Compactness
– Eccentricity
Materials & MethodsMethods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
GGO CAD• Materials
– 120KVp, 120 effective mAs– 3.2 mm slice thickness – Average 126.9 images/patient
• ROI selection– 32x32 matrix in lung area
• Texture Analysis – Ave, std, kurtosis, skewness, etc…
• Classification– Support Vector Machine
Methods1. Concept overview2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
GGO CAD Program (MatLab)Methods1. Concept overview
2. 3DMM Algorithm3. GGO Enhanced Image4. Support Vector Machine
Contents
• Introduction– What is CAD?– What is Ground Glass Opacity?– Previous GGO CAD algorithm– Purpose & Idea
• Methods– Concept overview– 3DMM algorithm– GGO Enhanced Image– Support Vector Machine
• Results• Conclusion
Detected GGO nodule with yellow box
Results
Overall sensitivity 84%(11/13) with 1.4 false-positive detections/study
Detected GGO nodule with yellow box
Results
Sensitivity is depend on– SVM kernel type, SVM input parameters, etc…
Contents
• Introduction– What is CAD?– What is Ground Glass Opacity?– Previous GGO CAD algorithm– Purpose & Idea
• Methods– Concept overview– 3DMM algorithm– GGO Enhanced Image– Support Vector Machine
• Results• Conclusion
Conclusion
• In this paper, we proposed a novel diagnosis algorithm for GGO detection. Our CAD algorithm is a new & efficient for detection of GGO nodules using 3D morphologic features, 2D texture analysis and support vector machine learning method.
• Enhanced GGO Image and support vector machine is good combination for GGO detection.
• With more patients and performance evaluation of SVM classifier, our CAD system will be improved.
감사합니다 감사합니다 !!!!