NCSUniversity System

A Project of NCS Education System

Tanveer TaraSenior Lecturer

Bachelor of Science in MLTMasters of Science in Hematology

Non Malignant Lymphocyte disorders.

Acquired and Conjenital

Acquired:Quntative in nature and self limited reactive process to infection or inflamatory conditions.Stimulated lymphocytes in infections and inflammatory

conditions are in various stages of activation.Changes:

Morphological changes,Lymphadenopathy

Splenomegaly…….

Acquired Quantitative disorders

• Lymphocytosis:• Increased lymphocytes ALC 4x109/L • Children 9x109/L• Peripheral Cells 60% to 80%.• Causes :• Infectious mononucleosis• EBV• Toxoplasmosis• Cmv• Infectious LymphocytosisB• Bordetella• Lymphocytic Leukomoid Reactions.• Plasmacytosis

INFECTIOUS MONONUCLEOSIS

• Lymphoproliferative cause by EBV.• Effect young adults 14-24 yeear,• Children before 4 years of age.• Transmitted via Saliva ………• EBV receptors on lympo Cd21.• Lethargy ,headache ,fever ,chills ,sorethroat,• :

Lab diagnosis

• Counts …high 12-25• Lymphocytes >50/%• Reactive lymphocytes• Plasmacytoids cells also present.• Paul Bunnel test.• Increased ALT, AST, and lactic acid

dehydrogenase levels in blood• Jaundice (occurs in about 5% of cases)

Infectiousmononucleosis

TOXOPLASMOSIS

• A disease caused by toxoplasmas, transmitted chiefly through undercooked meat, or in soil or cat feces. Symptoms generally pass unremarked in adults, but infection can be dangerous to unborn children.