Usefulness and limitations of taste sensors in the evaluation of palatability and taste masking in oral dosage form

Presented by Arantha j joseph

First year MPharm

This is a review taken from Asian journal of pharmaceutical sciences done by TamamiHaraguchi from school of pharmaceutical seience mukogawa womens university japan published on 31 August 2015.

In various types of formulation solid oral forms are most common

Advantages• Dose accuracy .• stability.• modify drug release profile .• delay or sustain therapeutic effect.

Tablets even plain associated with problems like difficulty in swallowing due to

large size. sticking to the throat mucosa . irritation of the pharyngeal region. coughing or choking.

One way of eliminating this is the use of orally disintegrating tablets(ODT)

In ODT acute drug concentration reaches the oral cavity is high due to the immediate disintegration of tablet in saliva. There for taste masking technology must be involved if the active ingredient is bitter or astringent.

o Disintegration time is an essential factor for determining its palatability

Advantages if ODT

Quick disintegration after contact with saliva in mouth.

facilitating swallowing ease of delivary increase patient adherence

Human sensation test is a major method of evaluating palatability

It should be accurate and precise Ethical issues are for testing drugs like

anti neoplastic agents in humans

So we are using artificial taste sensors Insent taste sensing system Alpha-ASTREE electronic tongue

are using.

Insent Taste Sensing System It composed of lipid polymer membrane Insent taste sensing system exhibits

different taste qualities like Bitterness Sourness Saltiness Umami sweetness

Advantages

Highly skilled Each taste sensor membrane response

particular taste

Disadvantages

Some substances are not detected

Antibiotics like clarithromycin dry syp have been evaluated using this system, a good correlation was obtained between the results of human gustatory sensation testing

Suppression of unpleasant taste also can be predicted

ALPHA-ASTREE ELECTRONIC TONGUE It is a quantitative sensor Evaluate overall taste of a product by using

electrodes Consist if 7 liquid cross sensitive electrodes An auto sampler Interface electronic module Each electrodes contain an organic membrane Any interaction at the interface of this

membrane is detected and convert into electric signal

Advantage

Evaluate overall taste Qualitative evaluation Compare elucidation distance Represents similarly in taste

EVALUATION OF OTDTs 3 different apparatus are used for

estimating disintegrated time OTD-101 TRI CORP TESTER OD MATE

Combined taste sensor and apparatus to estimate disintegration time of ODTs The combination of taste sensing system

and an apparatus to estimate disintegration time to predict the Palatability of ODT

Eg: Combination of incent taste sensing and

OD mate Alpha ASTREE electronic tongue an OD

mate

conclusion As per the comparative study the

authors reported that the both systems have their own usefulness and limitations

Although the combination of taste sensing system and an apparatus to estimate disintegration time would be useful for prediction the palatability of OTDs

THANK YOUPRESENTED BY ARANTHA.J.JOSEPH