UCLA CTSI Clinical and Translational Science Institute

NIH K Award Workshop July 26, 2012

Steven Dubinett, MD Director, Clinical and Translational Science Institute Senior Associate Dean and Associate Vice Chancellor for Research www.ctsi.ucla.edu

Outpatient & community based research Inpatient

GCRC

Training in clinical and translational team science

Regional and national consortia linked for collaboration

Traditional training

Individual academic

medical centers

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Purpose of the National CTSA Program

Providing an infrastructure for clinical and translational research

Transdisciplinary team science Individual investigators

NIH CTSA Consortium

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What is translational research?

UCLA translational investigation extends from molecules to society

Translating knowledge gained from laboratory science into clinical practice to improve health.

The aim of translational research is to produce new:

•  therapeutics •  medical devices •  tools for diagnosing disease •  avenues for community engagement research

Catalyst  Grants  

Rapid  Response  Team  

Prototype  Grants  

CTSI  Scholars  Awards  

Team  Science  Awards  

Novel  Methods    &  Technologies  Award  

Pilots   Team  Building   Proposal  Development   Proof-­‐of-­‐Concept  Pilots   Team  Building   Proposal  Development   Proof-­‐of-­‐Concept  

Overview of Pilot Programs

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Early Career Awards Opportunity Funds Grant Amount Duration of

Award (Years) Award Cycle Application

Due Date

KL2  Awards:  to  pursue  interdisciplinary,  mentored  research  with  training  

Up  to  $125,000  in  salary  and  

research  support

1 year at 75% effort

(renewable for up to 3 years)

July  1   Early  March  2013  

TL1  Transla/onal  Science  Fellowship: PhD  candidates  in  the  Department  of  Health  Services  in  the  UCLA  School  of  Public  Health  receive  mentored  training  to  ensure  the  translaNonal  nature  of  their  dissertaNon  projects

Annual  sNpend  plus  funding  for  

health  insurance,  

tuiNon/fees,  and  training-­‐related  

travel

Renewable for up to 4 years

Annual UCLA  School  of  Public  Health  applicaNon  deadline  is  

December  1,  2012  

TL1  Summer  Program  for  Professional  Students:  provides  professional  students  (medical,  nursing  and  dental)  early  exposure  to  interdisciplinary,  community-­‐partnered  translaNonal  or  health  services  research

Summer  sNpend  plus  funding  for  training-­‐related  

expenses

The summer between

student’s first and second

year (8 weeks)

June 1 Late  March  2013  

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Prioritized for Early Career Opportunity Funds Grant

Amount Duration of Award (Years)

Award Cycle

Application Due Date

Vouchers:    for  core  services  at  CTSI  insNtuNons

Up  to  $10,000  

1   Biannual   Sept.  28,  2012  

Seed  Grants:  to  support  research  projects  encouraging  translaNonal  science

$1,000  to  $30,000  

Up  to  1  year   Biannual   RFA  to  be  released    Fall  2012  

Scholar  Awards:  seed  funds  for  junior  faculty      

Criteria:    • Quality  of  the  scienNfic  proposal  • Candidate’s  potenNal  for  an  independent    translaNonal    research    career    • PotenNal  translaNonal  impact  of  the  research  and  relevance  to  the  overall  translaNonal  research  mission  of  the  UCLA  CTSI  

Up  to  $30,000  

Up  to  1  year   Annual   Sept.  27,  2012  

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Other Collaborative Funding Opportunities

Opportunity Funds Grant Amount

Duration of Award (Years)

Award Cycle

Application Due Date

Team  Science  Awards:  mulNdisciplinary,  cross-­‐insNtuNonal,  translaNonal  science  leading  to  a  proposal  under  such  team-­‐science  mechanisms  as  P01,  U54,  and  center  grants

Up  to  $200,000  

1-­‐2  years   Annual   Rolling  

Catalyst  Awards:  to  support  seminar  series,  team-­‐building  acNviNes  and  pilot  studies  and  other  acNviNes  to  encourage  translaNonal  team  science

$1,000  to  $25,000    

Up  to  1  year   Quarterly   RFA  to  be  released    August  15,  

2012  

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KL2 Year 1 Awardees

Assistant Professor, CDU “ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice”

Amira Brown, MS, PhD

Assistant Professor, Pediatric Nephrology, UCLA “ Hepcidin and the Anemia of Chronic Kidney Disease”

Joshua Zaritsky, MD, PhD

Assistant Professor of Medicine, UCLA/VA “ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults”

Gelareh Gabayan, MD, MSHS

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KL2 Year 2 Awardees

Assistant Professor, UCLA-Harbor / LA-BioMed “Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization”

James McKinnell, MD

Assistant Professor, UCLA “Modeling of EMT/MET transitions in breast cancer stem cells”

Mary Sehl, MD, PhD

Assistant Professor, UCLA “Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer”

David Shackelford, PhD

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Examples of Year 1 Team Science Awards

Stroke/cardiovascular disease in underserved minority populations: •  working with community partners, design and test

interventions to reduce risk of disease

Barbara Vickrey, MD, MPH

DMH-UCLA-USC Public Mental Health Translational Research Consortium:

•  in partnership with LA County and USC, implement best practices within the public mental health system

Joel Braslow, MD, PhD

Overcoming acquired resistance to B-Raf targeting in melanoma using phospho-proteomics and microfluidics:

•  Building a comprehensive program for signaling discovery and diagnostics to guide kinase inhibitor clinical trials in melanoma

Antoni Ribas, MD

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Current Team Science Award Partners

•  AIDS Institute

•  Jonsson Comprehensive Cancer Center

•  Broad Stem Cell Research Center

•  Cardiovascular

•  Neuroscience

•  Patient Safety Institute (PSI)

•  Center for AIDS Research (CFAR)

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Current Seed Grant Partners

•  Center for Autism Research & Treatment (CART)

•  Cousins Center for Psychoneuroimmunology

•  Women’s Health Center

•  Resource Centers for Minority Aging Research /

Center for Health Improvement for Minority

Elders (RCMAR/CHIME)

•  Pepper Center

Clinical and Translational Research Center (CTRC)

Ambulatory Clinical Research Facilities

•  7 private rooms, infusion rooms, 2 procedure rooms

•  >20,000 sq ft outpatient area

•  Clinical and Research Sleep Center

•  Interview and conference rooms

•  A service center including pharmacy and sample processing

•  23 hour capacity

First Year accomplishments

  400 ongoing research projects   80 new protocols   4800 out-patient

& 210 in-patient stays

CTSA Regional Consortia

University of California, Los Angeles

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UC Biomedical Research Acceleration Integration and Development (UC-BRAID)

•  A committee of the CTSA PIs at UC Davis, San Diego, San Francisco, Irvine and Los Angeles

•  Initial focus on contracting, informatics and IRBs

•  Drug discovery and development

•  Biobanking and global consent

•  Future inclusion of UCLA CTSI partner institutions

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UC Biomedical Research Acceleration Integration and Development (UC-BRAID)