Solution to Solution to Hormonal Dependent Hormonal Dependent Skin Symptoms Skin Symptoms by by Tom Jackson Tom Jackson Dermavista.com Dermavista.com 1.800.767.6765 1.800.767.6765
1. Solution to Hormonal Dependent Skin Symptoms by Tom Jackson
Dermavista.com 1.800.767.6765
2. Greece
3. Hormones in the adipose
Testosterone
Estrogen
4. A hormone (Greek to set in motion)
A Hormone is a chemical messenger
that carries a message from one cell
or a (group of cells) to another
5. Testosterone Metabolism
6. Testosterone Metabolism
7. What are Phytosterols?
Phytosterols , also known as plant sterols , are a naturally
occurring class of compounds found in the cells and membranes of
plants. These plant lipid-like compounds are present at low levels
in grains, fruits and vegetables . There are approximately 250
different sterols and related compounds in plant and marine
materials with the most common ones beta-sitosterol, stigmasterol,
and campesterol. Used to inhibit the production of enzymes 5 alpha
reductase/aromatase
Interrupt the message
.
8. Phytosterolic Complex BioComplex
Hydrophobiceasily absorbed by skin
Interfere with the enzymes:
5a-reductase and aromatase
hypoallergenic
Non-toxic
Local not systemic absorption
9. CELLULITE
10. Cellulite
11. Hormone Estrogen Enzyme - Aromatase
12. Normal Estrogen Production In Skin
13. BioComplex interrupts and changes the message to the
cells
14. SUBCUTANEOUS
15. Before After
16. ReGenesis A - 8 weeks of daily use
17. Woman in her 40s; 2 x day for 60 days
18. Reduction of Spider Veins
19.
Aim
Through the test one can evaluate if the tested cosmetic
product has got a cosmetic anti-cellulite effect, in particular if
its daily use can significantly change the skin parameters of
compactness, smoothness, complexion, orange peel, nodules,
microcirculation and the impendance values.
Test Subjects
30 females with cellulite, with an age between 18 and 70 years
of age, have been selected for the test, following the
undermentioned inclusion criteria:
ENVIRONMENTAL CAUSES : diet, aerobic and anaerobic exercise,
oral contraceptives, sedentary life.
REGENESIS BioComplex ANTICELLULITE CREME GEL
21. HISTOLOGY NORMAL ASPECT Network of Pre-Collagen Reticular
Fibrils Blood Vessel Adipocytes Interstice between Adipocytes Under
normal conditions, the adipose tissue is well sprinkled: the
capillary vessels are very close to the adipocytes cytoplasmatic
membrane. REGENESIS BioComplex ANTICELLULITE CREME GEL
22. HISTOLOGY PATHOLOGICAL ASPECT-1st and 2nd stage The first
consequence of the venular stasis is the abnormal endhothelial
permeability followed by the transudation of plasma into the
interstitial tissue. Ectasia- microaneurisms of blood transudate
Dissociation of Adipocytes Edematous Transudate Flooding of
Interstices REGENESIS BioComplex ANTICELLULITE CREME GEL
23. HISTOLOGY PATHOLOGICAL ASPECT -3rd stage PATHOLOGICAL
ASPECT -4th stage Representation of a micronodule: a considerable
number of altered adipocytes is surrounded by a full-fledged
capsule of collagenous fibrils and consequently isolated from the
tissue. The merging of several micronodules, having microscopic
dimension, give rise to so-called macronodule, that can be detected
through digital palpation. Capsule of thick-scleroialinotic
connetive fibrils Adipocytes altered by abiotrophic regressive
processes Macronodules capsule Micronodules forming
macronodule
24. Capillaries and microhemorhages
25. Vol. 19 After 60 days of treatment the structure of the
capillaries improved and the microhaemorrhages decreased T= 0 T= 60
days T= 60 days Gens 01/p Gens 01/v
26. Vol. 21 After 60 days of treatment the structure of the
capillaries improved and the microhaemorrhages decreased T= 0 T= 60
days T= 60 days Gens 01/p Gens 01/v
27. Vol. 10 After 60 days of treatment the structure of the
capillaries improved and the microhaemorrhages decreased T= 0 T= 60
days T= 60 days Gens 01/p Gens 01/v
28. Vol. 12 After 60 days of treatment the structure of the
capillaries improved and the microhaemorrhages decreased T= 0 T= 60
days T= 60 days Gens 01/p Gens 01/v
29. Skin tightening ReGenesis B
30. Application for ReGenesis A
Treatment phase: 2 x daily for 12 weeks
Maintenance phase: 2 x week or as needed
Apply ReGenesis B on flaccid skin
31. H.Ogel for permanent hair removal for women only
32. 62% of women over 14 years old remove hair at home
33. Three phases of hair growth
34. Waxing: the strongest stimulus for hair growth
Each time we use wax epilation, we simply induce the completely
opposite result because the cause of unwanted hair is not only
preserved by also reinforced
Waxing synchronizes most of the hairs to the antagen phase
35. Interrupt the message to the enzyme 5a-reductase
36. Clinical Study H.O g el
50 Subjects females between 18 and 50 years of age
Method of application:
The product was uniformly applied on specific body areas that
had been previously depilated with warm wax . Clinical Studies
lasted six months. The product was applied following the doctors
instructions reported in a form that was given to each
volunteer.
Execution of the test:
On recruiting volunteers as well as during monthly visits, our
dermatologists carried out a phototrichogram (hair count which
takes into account hair thickness, colour and length) on a
well-defined area. Checks were carried out after 30 days (T30), 60
days (T60), 90 days (T90), 120 days (T120), 150 days (T150) and 180
days (T180) - each time the day before epilation.
37. Reduction in hair number over time
38. Reduction in number of hair
39. Hair Number
40. Hair Regrowth
41. Clinical Study Conclusions
As one can notice, the product called H.O g el :
Can significantly reduce the number of hair and delay the hair
re-growth during the period of its application .
Moreover, the products application prevents the typical after
depilation sensations such as skin reddening, burning or hurt.
According to the obtained results the product H.O g el has
proved, on the volunteers who underwent this study, to have a:
COSMETIC POWER OF DELAYING HAIR RE-GROWTH
Experimenter Dr.ssa Evelyn FALCONI KLEIN
Monitor Prof. Fulvio MARZATICO
Quality Control Dr. Claudio ANGELINETTA
42. Conclusions
The clinical study on 50 women over a period of 180 days with a
monthly photographic documentation before epilation has proven the
high efficacy of the sterol complex BioAlpha inhibiting
5-alpha-reductase and aromatase in the skin.
In addition to the clear results concerning both number and
quality of re-growing hair it can be observed that the surface of
the skin is always exhibiting less wrinkles than at the beginning
of the study. This is due to the fact, that the active sterol
complex is also inhibiting slightly the aromatase enzyme.
Inhibition of the local production of estradiol is leading to an
increase of the collagen-concentration within the skin thereby
smoothing the surface.
Heinrich Wieland, M.D.,
Professor of Clinical Chemistry,
Director of the Department of Clinical Chemistry,
University Hospital, Freiburg, Germany
43. No Irritation
The product called H.O g el :
H as neither a cytotoxic effect nor a potential irritating
effect at the concentrations (between 5 mg/ml and 0.039mg/ml) of
the test compounds.
H.Ogel stimulates the regrowth of keratinocytes in vitro.
Experimenter Dott.ssa Nadia LOSIO
Monitor Dott.ssa Elena BOCCHIETTO
Quality Control Dr. Claudio ANGELINETTA
44. T 0 T 30 T 60 T 90 T 120 T 150 T 180 6 Very evident
variation in number of hair which regrow after treatment 4 Evident
variation in hair number 2 Slight variation in hair number 0 No
variation in hair number Value Hair number 6 Hair re-grow finer and
de-pigmented 4 Hair re-grow finer 2 Hair re-grow a little bit finer
0 No variation Value How hair re-grow 6 6 6 6 4 2
Hair number
6 6 6 4 4 2
How hair re-grow
T 180 T 150 T 120 T 90 T 60 T 30 Rif Vol V40
45. T 0 T 30 T 60 T 90 T 120 T 150 T 180 6 4 4 2 2 0
Hair number
6 4 4 2 2 2
How hair re-grow
T 180 T 150 T 120 T 90 T 60 T 30 Vol. ref. V01 6 Very evident
variation in number of hair which regrow after treatment 4 Evident
variation in hair number 2 Slight variation in hair number 0 No
variation in hair number Value Hair number 6 Hair re-grow finer and
de-pigmented 4 Hair re-grow finer 2 Hair re-grow a little bit finer
0 No variation Value How hair re-grow
46. T 0 T 30 T 60 T 90 T 120 T 150 T 180 6 6 6 6 4 2
Hair number
6 4 4 4 2 0
How hair re-grow
T 180 T 150 T 120 T 90 T 60 T 30 Rif Vol V05 6 Very evident
variation in number of hair which regrow after treatment 4 Evident
variation in hair number 2 Slight variation in hair number 0 No
variation in hair number Value Hair number 6 Hair re-grow finer and
de-pigmented 4 Hair re-grow finer 2 Hair re-grow a little bit finer
0 No variation Value How hair re-grow
47. T 0 T 30 T 60 T 90 T 120 T 150 T 180 6 Very evident
variation in number of hair which regrow after treatment 4 Evident
variation in hair number 2 Slight variation in hair number 0 No
variation in hair number Value Hair number 6 Hair re-grow finer and
de-pigmented 4 Hair re-grow finer 2 Hair re-grow a little bit finer
0 No variation Value How hair re-grow 4 4 2 2 2 0
Hair number
6 4 4 4 4 0
How hair re-grow
T 180 T 150 T 120 T 90 T 60 T 30 Rif Vol V28
48. T 0 T 30 T 60 T 90 T 120 T 150 T 180 6 Very evident
variation in number of hair which regrow after treatment 4 Evident
variation in hair number 2 Slight variation in hair number 0 No
variation in hair number Value Hair number 6 Hair re-grow finer and
de-pigmented 4 Hair re-grow finer 2 Hair re-grow a little bit finer
0 No variation Value How hair re-grow 6 6 6 6 4 2
Hair number
6 6 6 4 4 2
How hair re-grow
T 180 T 150 T 120 T 90 T 60 T 30 Rif Vol V40
49. Application for HOgel
Treatment phase: wax twice in first month, apply 2 x per day
for 6 months
Maintenance phase: 2 x per week as needed
Anywhere on female body
50. Aknof
51. Sebum and Acne
52. Sebacious glands
53. Before
54. After
55. Before
56. After
57. Before
58. After
59. Before
60. After
61. Application of Aknof
Wash face with Aknof cleansing gel daily
Apply Aknof cream 2 x per day
Results will be visible within 60 days with maximum clearance
in 3 to 6 months
62. HAIR REGROWTH
63. What causes Alopecia? Male and female pattern baldness
Decreased testosterone production
Decreased microcirculation in the dermal papilla
64. Inhibits production of 5 alpha reductase
65. Minoxidil
induces very limited progress while it seems that it leads not
only to the development of undesirable hair on the face but also to
an abrupt loss of scalp hair immediately ater the discontinuance of
the treatment (rebound effect)
( M.P. Birch, Clinical and Experimental Dermatology, 2002)
66. Finasteride
Administered to women with androgenic alopecia resulted in a
complete failure
Journal of American Academy of Dermatology
67. Hair regrowth
68. Application for Follon
Use Follon Shampoo 2-3 x per week
Apply Follon Tincture to scalp 2 x per day
Take 1 Follon Capsule morning&evening
Results show 3 months; completion of treatment varies from 6 12
months
69. For more information about products for Hormone Dependent
Skin Symptoms contact: Dermavista.com 1.800.767.6765
