Progress in the RNOH-IOMS Joint Academic Strategy

Progress in the RNOH-IOMS Joint Academic Strategy

David Marsh

Professor of Clinical Orthopaedics, Institute of Orthopaedics and Musculoskeletal Science University College London

Acting R&D Director, Royal National Orthopaedic HospitalStanmore, UK

Trust BoardJuly 2008Trust BoardJuly 2008

Academic Health Science CentreAcademic Health Science Centre

• Joint Academic Plan:– integration of UG and

PG education – R&D management

into IOMS– Research strategy

EXCELLENCE,INTEGRATION

EDUCATION

RESEARCH

CLINICAL

Research StrategyResearch Strategy

• Focused on musculoskeletal system but full spectrum

• Five themes, building on track record and patient needs Innovative implant design Cell therapy and tissue engineering Disability and improvement of quality of life Building the musculoskeletal evidence base Sarcoma medicine

Basic scienc

e

Translational

Experimental

Clinical

trials

Health service

s researc

h

Academic Research

Board

Research Committee

Education Committee

Trust Board

PPI group

UCL and Partners Health

Sciences Research Deanery

Institute of Orthopaedics

and Musculoskeletal

Science

UCL Dean and Research Vice-

Provost

05 06 07 08 09 10 11 12

NHS R&D

UCL

NIHR Applied Research Programme £2m

Pfizer fracture accelerating drug 500k

TSB grant 500k

MRC stem cells in nonunion 300k

Expenditure

Grant targetoverheads, contributions to salary, SCRF profit

UpdateUpdate

• Research Committee• Clinical research facility• Cell therapy GMP facility• Funding

Research CommitteeResearch Committee

• Meeting fortnightly• Agenda evolving

– Research governance: trial masterfiles, investigator files, GCP– Clinical research, pipeline– Links with LCRN, Deanery etc

• First meeting of Academic Board planned for September

Rob Hurd Exec TeamNerina Bee Academic Business DevelopmentJoseph Fatukasi R&D ManagerSimon Grange Clinical SL, Assistant R&D DirectorRichard Keen Research-active consultantSue Marchetto Lead research nurseDavid Marsh Clinical Professor, R&D Director

Cell-based therapyCell-based therapy

• Previous clinical trials in ACI• Preclinical work on bone, collagen• Regenerative Medical Systems – UK

– Lease signed for Centennial Park– Permanent staff coming in Sep– On stream Q1 - 2009– Scientific Board

• Translational teams: – Bone,Tendon,Cartilage

MRC Translational Research CallMRC Translational Research Call

• £241m extra, most on translational research– Bottlenecks

• Pan-UCL bid going in– MRC Centre for Cell and Gene Therapy

• Stanmore hopefully to contribute cell therapy in the musculoskeletal system

FundingFunding

• Extra £196k from NIHR• Grants secured

– MRC cells in impaction grafting– Vibration therapy in distraction osteogenesis– Instrumented IM nail– ITAP– ~15 trials in the pipeline

• Grants in preparation

Full economic costing