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Progress in the RNOH-IOMS Joint Academic Strategy
Progress in the RNOH-IOMS Joint Academic Strategy
David Marsh
Professor of Clinical Orthopaedics, Institute of Orthopaedics and Musculoskeletal Science University College London
Acting R&D Director, Royal National Orthopaedic HospitalStanmore, UK
Trust BoardJuly 2008Trust BoardJuly 2008
Academic Health Science CentreAcademic Health Science Centre
• Joint Academic Plan:– integration of UG and
PG education – R&D management
into IOMS– Research strategy
EXCELLENCE,INTEGRATION
EDUCATION
RESEARCH
CLINICAL
Research StrategyResearch Strategy
• Focused on musculoskeletal system but full spectrum
• Five themes, building on track record and patient needs Innovative implant design Cell therapy and tissue engineering Disability and improvement of quality of life Building the musculoskeletal evidence base Sarcoma medicine
Basic scienc
e
Translational
Experimental
Clinical
trials
Health service
s researc
h
Academic Research
Board
Research Committee
Education Committee
Trust Board
PPI group
UCL and Partners Health
Sciences Research Deanery
Institute of Orthopaedics
and Musculoskeletal
Science
UCL Dean and Research Vice-
Provost
05 06 07 08 09 10 11 12
NHS R&D
UCL
NIHR Applied Research Programme £2m
Pfizer fracture accelerating drug 500k
TSB grant 500k
MRC stem cells in nonunion 300k
Expenditure
Grant targetoverheads, contributions to salary, SCRF profit
UpdateUpdate
• Research Committee• Clinical research facility• Cell therapy GMP facility• Funding
Research CommitteeResearch Committee
• Meeting fortnightly• Agenda evolving
– Research governance: trial masterfiles, investigator files, GCP– Clinical research, pipeline– Links with LCRN, Deanery etc
• First meeting of Academic Board planned for September
Rob Hurd Exec TeamNerina Bee Academic Business DevelopmentJoseph Fatukasi R&D ManagerSimon Grange Clinical SL, Assistant R&D DirectorRichard Keen Research-active consultantSue Marchetto Lead research nurseDavid Marsh Clinical Professor, R&D Director
Cell-based therapyCell-based therapy
• Previous clinical trials in ACI• Preclinical work on bone, collagen• Regenerative Medical Systems – UK
– Lease signed for Centennial Park– Permanent staff coming in Sep– On stream Q1 - 2009– Scientific Board
• Translational teams: – Bone,Tendon,Cartilage
MRC Translational Research CallMRC Translational Research Call
• £241m extra, most on translational research– Bottlenecks
• Pan-UCL bid going in– MRC Centre for Cell and Gene Therapy
• Stanmore hopefully to contribute cell therapy in the musculoskeletal system
FundingFunding
• Extra £196k from NIHR• Grants secured
– MRC cells in impaction grafting– Vibration therapy in distraction osteogenesis– Instrumented IM nail– ITAP– ~15 trials in the pipeline
• Grants in preparation
Full economic costing