I
N M
NANOPARTICLES AND NANOTECHNOLOGY
Intelligent Nanomaterials
I
N M
CORPORATE PURPOSE
INTENANOMAT: Intelligent NanomaterialsABOUT US
DESIGN AND FABRICATION OF NANOPARTICLESFabrication, characterization and integration of nanomaterials into new products.
I
N M APPLICATIONS OF NANOPARTICLESNANOPARTICLES
NanoparticleNanoparticle
Textiles
BiomedicalRenewableEnergy
FoodAgriculture
Health CareEnviroment
Electronics
Industrial
I
N M
I
N M
WHAT IS A NANOPARTICLE?
I
N M
0.1 nm 1 nm 10 nm 100 nm 1 μm 10 μm 100 μm 1 mm
Water DNA Virus Bacteria Red Blood Cell Hair FleaGlucose
NANOMATERIALS
Nanoparticles NanocompositeNanotubesThin Films
WHAT IS A NANOPARTICLE?THE NANOSCALE
I
N M WHAT IS A NANOPARTICLE?THE NANOSCALE
Nanoparticle
Soccer Ball
Earth
Order 10‐7
Order 1
Order 10 7
Nanoparticles are small compared to most particlesCan reach sites not accessible with larger particles with superior properties
I
N M
WHY NANOPARTICLES?
I
N M
Things are different at the nanoscale
Size really does matter!
WHY NANOPARTICLES?THE NANOSCALE
BulkBulk
Silver Gold
Nanoscale
I
N M
TYPES OFNANOPARTICLES
I
N M TYPES OF NANOPARTICLES
Metal Nanoparticles Semiconducting Nanoparticles(Quantum Dots)
Magnetic Nanoparticles Metal Oxide Nanoparticles
Carbon‐based Nanomaterials
I
N M NOBLE METAL NANOPARTICLES
107.86
Ag47
Silver
169.96
Au79
Gold
195.08
Pt78
Platinum
Strong Absorption of Light
I
N M
Shape DependenceAu Nanoparticles
Size DependenceAu Nanoparticles
8 nm 12 nm 30 nm 50 nm 70 nm 110 nm
150 nm
150 nm 150 nm
150 nm
NOBLE METAL NANOPARTICLES
I
N M
Optical properties of Metal NPs: Determined by size, shape, assembly
and environment of NPs.
NOBLE METAL NANOPARTICLES
Full‐Spectrum Absorption Of Light Full‐Spectrum Absorption Of Light
I
N M SEMICONDUCTING NANOPARTICLES
ZnS PbSCdSe PbSe
2 nm 6 nmDiameter (nm)
Absorption and Photoluminescence
CdTe
InP
I
N M
Materials of Interest: Chalcogenide Semiconductors (II-VI and IV-VI)
ZnS (2.5 nm)
ZnSe (3.8 nm)
400 nm 700 nm 2500 nmUV VISIBLE IR
200 nm
CdS (2.8 nm)
CdSe (4.9 nm)
PbS (18 nm)
PbSe (46 nm)
PbTe (150 nm)
CdTe (6.5 nm)
Bohr Radius
SEMICONDUCTING NANOPARTICLES
Full‐Spectrum Source Of Light Full‐Spectrum Source Of Light
I
N M MAGNETIC NANOPARTICLES
169.96
Co79
Fe3O4
Superparamagnetism
I
N M METAL OXIDE NANOPARTICLES
SiO2
ZnOTiO2 NiO
PhotoCatalytic Properties
I
N M CARBON‐BASED NANOMATERIALS
Nanodiamonds Nanotubes
GraphenePolymers
I
N M METAL OXIDES AND OTHER NANOPARTICLES
Nanodiamonds
SiO2 Fe3O4
100 nm
I
N M
APPLICATIONS IN BIOTECHNOLOGY
I
N M NANOPARTICLES IN BIOTECHNOLOGY
Surface FuntionalizationLarge Surface Area
Bioactive Nanoparticles
NP
WHY?WHY?
I
N M LARGE SURFACE AREANANOPARTICLES IN BIOTECHNOLOGY
100‐nm Au nanoparticle can take 200.000 molecules
Crushed
Single Particle(Diameter 1 cm)
Cluster of 1015 Particles(Diameter 100 nm)
Surface Area 3 cm2 Surface Area 30 m2
INCREASE OF 100.000 TIMES
I
N M NANOPARTICLE FUNTIONALIZATION
+ Bioconjugation
BioActive Nanoparticles
QD
BioActive MoleculeProtein, Peptide, Gene, DNA, siRNA, Antibody, Drugs…
Nanoparticle
QD
Easy functionalization of Nanoparticles
NANOPARTICLES IN BIOTECHNOLOGY
I
N M CLASSICAL MEDICINE VS NANOMEDICINE
NanoDrugsNanoDrugs
DISPERSION in all body
TARGETINGon Inflammed Cells
Targeting oninflammed zoneInflammed
Zone
HealthyCell
HealthyPart of Colon
I
N M DIAGNOSIS: IMAGING
QD
QD
QD
Selective Binding to Cancer Cells
Targeting Agent
I
N M THERAPY: DRUG DELIVERY
Cell Targeting and Drug Release
Membrane Cell
CellReceptors
BioActive Nanoparticles
Targeting Agent
Therapeutic Agent
1. Cell Targeting 2. Drug Release
Cell
I
N M THERAPY: HYPERTHERMIA
Magnetic Hyperthermia Therapy
Magnetic Nanoparticles
Targeting AgentFe3O4Fe3O4
Magnet
42‐46 ºC
I
N M
Theranostics: Simultaneous Diagnostics and Therapy
Theranostics: Simultaneous Diagnostics and Therapy
THERANOSTICS
Diagnostics(Imaging)
Nanoparticles
Therapy(Drug Delivery)(Hypertermia)
I
N MDIAGNOSIS PHOTOTHERAPY
(HYPERTHERMIA)
THERANOSTICS
TUMOUR CELL TUMOUR CELL HEALTHY CELL
Targeting Agent
Au@QD Nanoparticle
I
N M
APPLICATIONS IN FOOD
I
N M SENSORS
SENSORS BASED ON METAL NANOPARTICLES
Smart Packaging for Food Spoilage ControlSmart Packaging for Food Spoilage Control
I
N M
APPLICATIONS IN RENEWABLE ENERGY
I
N M
from 20‐30% to as high as 65% from 20‐30% to as high as 65%
PHOTOVOLTAIC CELLS
Theoretical increase of solar power efficiency
SOLAR CELLS BASED ON QUANTUM DOTS
ITO
SUN LIGHT
I
N M
APPLICATIONS IN OPTOELECTRONICS
I
N M LIGTH EMITTING DIODES (LEDs)
QLEDFLUORESCENTLAMPS
LEDs BASED ON QUANTUM DOTS
INCANDESCENT BULBS
Full‐Spectrum Source Of Light Full‐Spectrum Source Of Light
I
N M
APPLICATIONS IN ENVIROMENT
I
N M WATER PURIFICATION
Photocatalysis Based On Metal Nanoparticle
Au‐ZnO Film
Pollutant
Photodecomposition Process
DestroyedPollutant
Au NPZnO Film
SUN LIGHT
I
N M CURRENT ACTIVITYINTENANOMAT
RESEARCH IN FABRICATION OF NANOPARTICLES FOR RENEWABLE, ENERGY, OPTOELECTRONICS, ENVIROMENT, SENSING…
COMMERCIALIZATION OF NANOPARTICLES FOR COSMETICSAu, Pt Nanoparticles and Nanodiamonds
I
N M
1. Accelerating Commercialization of Nanomaterials and Internationalization
OUR GOAL
2. Research Projects Based on NanoScience
I
N M THE TEAMINTENANOMAT
Prof. Dr. José L. ValdésCEOProf. AstronomyCo‐Founder>120 Research Papers5 Patents
Prof. Juan P. Martínez‐PastorHead of UMDO Group at Uni. Valenciawww.uv.es/umdoProf. Applied PhysicsCo‐Founder>200 Research Papers. 6 Patents
Dr. Rafael AbarguesChief Technology OfficerPhD ChemistryCo‐Founder>60 Research Papers9 Patents
Ms. Sandra AlbertSynthesisMSc Chemistry6 Research Papers
Dr. Pedro J. Rodríguez‐CantoChief Production OfficerPhD Chemistry>20 Research Papers1 Patent