microangiopathic hemolytic anemia

microangiopathic hemolytic anemia

TTP

reticulocytes

Polychromasia

Autoimmune hemolytic anemia

Target Cells

•Increased surface to volume ratio

•Actually shaped like a bell (3D)

•Target cells are always hypochromic

•Excess membrane cholesterol and phospholipid

•Decreased osmotic fragility

•Hemoglobin C disease

•Liver disease

•Iron deficiency

•Any hemoglobin abnormality

•Post splenectomy

Target Cells

Target Cells (Codocytes)

Target Cells

10 y/o boy of Italian descent

Diagnosis : Beta thalassemia major Homozygous beta0 thalassemia Comment : beta0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A2) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice

Case 2

Howell Jolly Body

Sickle cell

Erythroblast

Sickle cells (Drepanocytes)

Sickle CellsSickle Cells

Sickle Cells