microangiopathic hemolytic anemia

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microangiopathic hemolytic anemia. microangiopathic hemolytic anemia. TTP. reticulocytes. Polychromasia. Autoimmune hemolytic anemia. Target Cells. Increased surface to volume ratio Actually shaped like a bell (3D) Target cells are always hypochromic - PowerPoint PPT Presentation

Text of microangiopathic hemolytic anemia

  • microangiopathic hemolytic anemia

  • microangiopathic hemolytic anemia

  • TTP

  • reticulocytes

  • Polychromasia

  • Autoimmune hemolytic anemia

  • Target CellsIncreased surface to volume ratioActually shaped like a bell (3D)Target cells are always hypochromicExcess membrane cholesterol and phospholipidDecreased osmotic fragility

  • Hemoglobin C diseaseLiver diseaseIron deficiencyAny hemoglobin abnormalityPost splenectomy

    Target Cells

  • Target Cells (Codocytes)

  • Target Cells

  • 10 y/o boy of Italian descentDiagnosis : Beta thalassemia major Homozygous beta0 thalassemia Comment : beta0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A2) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice

  • Case 2Howell Jolly BodySickle cellErythroblast

  • Sickle cells (Drepanocytes)

  • Sickle Cells

  • Sickle Cells