microangiopathic hemolytic anemia. microangiopathic hemolytic anemia. TTP. reticulocytes. Polychromasia. Autoimmune hemolytic anemia. Target Cells. Increased surface to volume ratio Actually shaped like a bell (3D) Target cells are always hypochromic - PowerPoint PPT Presentation
Text of microangiopathic hemolytic anemia
microangiopathic hemolytic anemia
microangiopathic hemolytic anemia
TTP
reticulocytes
Polychromasia
Autoimmune hemolytic anemia
Target CellsIncreased surface to volume ratioActually shaped
like a bell (3D)Target cells are always hypochromicExcess membrane
cholesterol and phospholipidDecreased osmotic fragility
Hemoglobin C diseaseLiver diseaseIron deficiencyAny hemoglobin
abnormalityPost splenectomy
Target Cells
Target Cells (Codocytes)
Target Cells
10 y/o boy of Italian descentDiagnosis : Beta thalassemia major
Homozygous beta0 thalassemia Comment : beta0 = beta gene producing
no beta chains no beta chains and hence no Hb A. untreated he has
about 95% Hb F (remainder being Hb A2) Treatment : Transfusion to
maintain hemoglobin level; Chelation therapy to remove excess iron
present due to hemolysis and transfusions. Bone marrow
transplantation is treatment of choice
![INDEX [cdn.ymaws.com] · thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage.10-12 These signs and symptoms largely overlap with another thrombotic](https://img.pdfslide.us/doc/110x75/5e1d32d611056a1bd1177b72/index-cdnymawscom-thrombocytopenia-microangiopathic-hemolytic-anemia-and-various.jpg?t=1680319706)
