Melanocytic Nevus or Melanoma, Gene DeterminesMole, as Benign tumor, exists in almost every adults skin. It has been long known that themutation o B!"# gene can cause the growth o mole. But why the moles sto$ growing is stillunknown. !ecently, researchers at %niversity o &ennsylvania have ound that a gene called'D(N)B *encodes $+, $rotein- is the key actor or a mole been stuck in a non.$rolieration,non.growing state. /his gene leads to the $ossibility that theres only one ste$ away romMelanocytic Nevus to Melanoma.Neviand melanomas both originate in the skin melanocytes. 0cientists have discovered adecade ago, the mutation o B!"# gene may lead to overgrowth o melanocytes, 1ust likeo$ening the valve o melanin growth, leading to the growth o nausea neviand melanoma.But dierent rom melanoma, when the melanocytic nevi in the skin accumulation reaches acertain si2e *ty$ically a ew millimeters in diameter-, the cells sto$ growing. But heres the3uestion4 why they are they the same B!"# mutation, mole inside melanoma cell $rolierationcan be limited, but the Melanoma can not5/odd 6. !idky MD is one o the researchers in this studies. 7e and his colleagues com$aredthe normal melanocytic nevi and melanoma cells rom ordinary. "s a result, they ound thatthe concentrations o a mole $rotein in Melanocytes is +89 times higher than those in theMelanoma cells. $+, is a $rotein associated with tumor trans$lantation, that can block somecell division, acting as a brake in the $rocess o tumor ormation. Nevus cells derived rom thismodel wouldhavebeenundernormal circumstancesandwill not develo$intomelanomacells, but i thecorres$ondinggene$+,$roteinwasknockedout, thecancerationwouldoccur. "t the same time,theyalso oundthatithe B!"# mutant $roteinactivity increases, itis$ossible to cause the cells to secrete a signaling molecule /G#.:*a cellular growth actor-./he high concentration o $+, has great signiicance in the maintenance o a benign mole.$+, hasasimilar $rotein,$+;, and they both $lay arolein cellgrowth inhibition. But theresearchers $roved that $+, has its own uni3ue eatures to limit the excessive $rolieration omelanocytic nevi. In.de$th research on $+, can hel$ us understand the ormation o the growth o melanomaand nevihistory. 0kin cancer.related diseases willincreasing as the ex$osure to ultravioletlight increases. /hereore, themelanomacell relatedresearchwill always haveaveryim$ortant $ractical signiicance.