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Page 1: Learning

Learning

Page 2: Learning

Quantifying Learning Beyond Exams…..

Principles of Neural Science (Kandel): Chapter 63

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Terms used to quantify learning in animal models:

• Habituation- animal is less reactive to an external stimulus

• Sensitization- animal is more reactive to an external stimulus

• Conditioning (albeit it classical or operant)- behavioral or physiological events are reinforced by pairing two external stimuli that are inherently mutually exclusive (bell and food)

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Neuronal Identification of Habituation vs Sensitization

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Neuronal Identifications of Habituation

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Neuronal Identifications of Habituation

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Neuronal Identifications of Sensitization

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Neuronal Identifications of Sensitization (Short-Term, Cytoplasmic)

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Neuronal Identifications of Sensitization (Long-Term, Nuclear)

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LTP vs LTD in the hippocampus

LTP: long-term potentiationLTD: long-term depression

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LTP vs. LTD is dependent on the number of connections and successful transmissions

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This results in a change in the intensity of neuronal firing, pre-synaptically

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And in a change in receptor expression, post-synpatically

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The fruit fly as a powerful tool to manipulate learning


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