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Learning. Quantifying Learning Beyond Exams…. Principles of Neural Science ( Kandel ): Chapter 63. Terms used to quantify learning in animal models:. Habituation - animal is less reactive to an external stimulus Sensitization - animal is more reactive to an external stimulus - PowerPoint PPT Presentation

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Page 1: Learning

Learning

Page 2: Learning

Quantifying Learning Beyond Exams…..

Principles of Neural Science (Kandel): Chapter 63

Page 3: Learning

Terms used to quantify learning in animal models:

• Habituation- animal is less reactive to an external stimulus

• Sensitization- animal is more reactive to an external stimulus

• Conditioning (albeit it classical or operant)- behavioral or physiological events are reinforced by pairing two external stimuli that are inherently mutually exclusive (bell and food)

Page 4: Learning

Neuronal Identification of Habituation vs Sensitization

Page 5: Learning

Neuronal Identifications of Habituation

Page 6: Learning

Neuronal Identifications of Habituation

Page 7: Learning

Neuronal Identifications of Sensitization

Page 8: Learning

Neuronal Identifications of Sensitization (Short-Term, Cytoplasmic)

Page 9: Learning

Neuronal Identifications of Sensitization (Long-Term, Nuclear)

Page 10: Learning

LTP vs LTD in the hippocampus

LTP: long-term potentiationLTD: long-term depression

Page 11: Learning

LTP vs. LTD is dependent on the number of connections and successful transmissions

Page 12: Learning

This results in a change in the intensity of neuronal firing, pre-synaptically

Page 13: Learning

And in a change in receptor expression, post-synpatically

Page 14: Learning

The fruit fly as a powerful tool to manipulate learning


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