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EndocrineandMetabolism
AtifHassanKhirelsied,B.Sc.,M.Sc.,Ph.D.f
Facult
ofMedicine
InternationalUniversityofAfrica,Khartoum,Sudan
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Theimportance
of
endocrine
system
Functionalcoordinationofbodysystems.
.
Conservationofhomeostasis.
Adaptationtoenvironmentalchanges.
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Courseintroduction
Number: FMHS511
Title: EndocrinologyandMetabolism
Coordinator: Dr.AtifH.Khirelsied(phone:0122169743)
Duration: 6Weeks
Credithours: 6hrs
committee
Dr.Atif
H.
Khirelsied,
Dr.
Fatma Elsmani,
Dr.
Ibtisam Ali,
Prerequisites
u r ona oc em s ry, n ro uc on o es u yo seases,
ManandEnvironment,GrowthandDevelopment,Gastro
intestinaltract.
Facilitiesand Lectureroom(150students),computerandmultimedia
Requirements projectors,dissectionroom, museum,libraryandlaboratory.
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characteristicsof
the
endocrine
system
and
elaboratesonthemorphology,biochemistry,
physiologyand
pathology
of
various
glands
endocrinesystem.
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Course GeneralObjectives
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,
studentsshouldbeableto;
1. Describetheoverallorganizationoftheendocrine
systemin
the
human
body,
and
identify
the
major
glandsandtheirlocations.
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U onsuccessfulcom letionofthiscourse the
studentsshouldbeableto;
2. Outlinetheroleofhormonesinthecontrolof
bodyfunctioning
and
describe
the
importance
ofhormonesinhealthanddiseases.
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Uponsuccessfulcompletionofthiscourse,the
studentsshouldbeableto;
3. Identifydifferentclassesofhormonesand
hormonereceptors,
and
describe
the
principles
o mo ecu ars gna nga ce u ar eve .
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Uponsuccessfulcompletionofthiscourse,the
studentsshouldbeableto;
4. Describethemajormetabolicpathwaysof
carbohydrates,lipids,
proteins
and
nucleotides
metabolism,andexplainhowthesepathways
system.
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,
studentsshouldbeableto;
5. Identifytheimportantclinicalconditions
associatedwith
hormonal
and
metabolic
disorders,andlearnhowtoevaluateendocrine
sor erscommon yseen npr mary ea t
.
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,
studentsshouldbeableto;
.
commonlyusedinhormonalassays.
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Course specificLearningObjectives
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1.Identify theorgansandtissuesoftheendocrine
systemanddescribetheirgeneralmorphologicaland
.
2.Define thevariousformsofcellularcommunication
andsignalingsystems(i.e.,endocrine,paracrine,
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3. Describethevariousclassesofhormonesbothin
termsoftheirstructuresandphysicochemical
propertiesaswellasmechanismsofaction.
4. Recognize thetypesofcellularresponsestohormones
anddefinepositiveandnegativefeedbackand
describetheirroleinregulatingbloodlevelsofvarious
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5. Identify thetarget,representativeactions,andsecretory
controlofthehormonesofthe;
. ,
6. pituitarygland,
7. pancreas,
9. parathyroidglands,
10. adrenalcortexandmedulla,
11. ineal land,th mus,ovaries,andtestes.
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5. Define generalprincipleofgenesexpressionandpeptide
hormonesynthesis,andrelatethesetocontrolof
hormonesynthesisandsecretion.
6. Discuss howhormonescoordinateandintegratethe
.
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major
metabolic
pathways
of
carbohydrates,
lipid,
amino
acidandnucleotidemetabolism.
8. Defineprostaglandins,whataretheymadeof,andwhat
aretheireffects?
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9. Recognize thecausesofdwarfism,giantism,acromegaly,
diabetesinsipidus,diabetesmellitus(Type1andType
2 cretinism m xedema Grave'sdisease sim le oiter
andCushing'ssyndrome.
.
andendocrinefunctiontests.
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11. Recognize the
endocrine
function
of
the; kidneys
Heart
Adiposetissues
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Course PBLSessions
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. .
2.Cushingssyndrome.
3.Diabetesmellitus.
4.Primaryinfertility.
th Elwathig)
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1. Studentsareexpectedtoattendlectures,tutorialsand
practical/studygroupsessions.
2. Failuretomeettheminimalattendancerequirements(75%ofecourseac v es mayresu nyou e ng eeme ne g e
forassessment.
.
withoutexcusewillnotbeallowedtositforthefinalexamand
will
be
deemed
fail.
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1.Readandfamiliarizehim/herwiththecontentsofthe
coursesyllabus.
2.Participateincourseactivitiesviaclassattendance,
discussion,and
note
taking,
seminar
preparation
and
presentation.
3.Readandstudyassignedreadingspriortobeingtested
over
the
material.
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Course Assessment
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Finalexamination:
accountsfor(70%)ofthetotalpoints
cons stso s ,s ortnotes ,
Thecontinuous
assessments:
accountsfor30%ofthetotalpoints
Include midcourse test re orts and PBL activities.
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Studentsscoreswillbegradedaccordingtothefollowing
scale.
core
Grade F C B B+ A
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Studentsfeedback(questionnaire).
Facultycommentsandobservations.
Analysisofexaminationresults.
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Course Timetable
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Davidson'sPrinciplesandPracticeofMedicine20thedition(2006).NicholasA.
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HarpersIllustratedBiochemistry,28th edition(2009). RobertK.Murray,Victor
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