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EndocrineandMetabolism

AtifHassanKhirelsied,B.Sc.,M.Sc.,Ph.D.f

Facult

ofMedicine

InternationalUniversityofAfrica,Khartoum,Sudan

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Theimportance

of

endocrine

system

Functionalcoordinationofbodysystems.

.

Conservationofhomeostasis.

Adaptationtoenvironmentalchanges.

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Courseintroduction

Number: FMHS511

Title: EndocrinologyandMetabolism

Coordinator: Dr.AtifH.Khirelsied(phone:0122169743)

Duration: 6Weeks

Credithours: 6hrs

committee

Dr.Atif

H.

Khirelsied,

Dr.

Fatma Elsmani,

Dr.

Ibtisam Ali,

Prerequisites

u r ona oc em s ry, n ro uc on o es u yo seases,

ManandEnvironment,GrowthandDevelopment,Gastro

intestinaltract.

Facilitiesand Lectureroom(150students),computerandmultimedia

Requirements projectors,dissectionroom, museum,libraryandlaboratory.

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characteristicsof

the

endocrine

system

and

elaboratesonthemorphology,biochemistry,

physiologyand

pathology

of

various

glands

endocrinesystem.

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Course GeneralObjectives

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,

studentsshouldbeableto;

1. Describetheoverallorganizationoftheendocrine

systemin

the

human

body,

and

identify

the

major

glandsandtheirlocations.

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U onsuccessfulcom letionofthiscourse the

studentsshouldbeableto;

2. Outlinetheroleofhormonesinthecontrolof

bodyfunctioning

and

describe

the

importance

ofhormonesinhealthanddiseases.

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Uponsuccessfulcompletionofthiscourse,the

studentsshouldbeableto;

3. Identifydifferentclassesofhormonesand

hormonereceptors,

and

describe

the

principles

o mo ecu ars gna nga ce u ar eve .

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Uponsuccessfulcompletionofthiscourse,the

studentsshouldbeableto;

4. Describethemajormetabolicpathwaysof

carbohydrates,lipids,

proteins

and

nucleotides

metabolism,andexplainhowthesepathways

system.

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,

studentsshouldbeableto;

5. Identifytheimportantclinicalconditions

associatedwith

hormonal

and

metabolic

disorders,andlearnhowtoevaluateendocrine

sor erscommon yseen npr mary ea t

.

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,

studentsshouldbeableto;

.

commonlyusedinhormonalassays.

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Course specificLearningObjectives

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1.Identify theorgansandtissuesoftheendocrine

systemanddescribetheirgeneralmorphologicaland

.

2.Define thevariousformsofcellularcommunication

andsignalingsystems(i.e.,endocrine,paracrine,

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3. Describethevariousclassesofhormonesbothin

termsoftheirstructuresandphysicochemical

propertiesaswellasmechanismsofaction.

4. Recognize thetypesofcellularresponsestohormones

anddefinepositiveandnegativefeedbackand

describetheirroleinregulatingbloodlevelsofvarious

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5. Identify thetarget,representativeactions,andsecretory

controlofthehormonesofthe;

. ,

6. pituitarygland,

7. pancreas,

9. parathyroidglands,

10. adrenalcortexandmedulla,

11. ineal land,th mus,ovaries,andtestes.

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5. Define generalprincipleofgenesexpressionandpeptide

hormonesynthesis,andrelatethesetocontrolof

hormonesynthesisandsecretion.

6. Discuss howhormonescoordinateandintegratethe

.

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major

metabolic

pathways

of

carbohydrates,

lipid,

amino

acidandnucleotidemetabolism.

8. Defineprostaglandins,whataretheymadeof,andwhat

aretheireffects?

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9. Recognize thecausesofdwarfism,giantism,acromegaly,

diabetesinsipidus,diabetesmellitus(Type1andType

2 cretinism m xedema Grave'sdisease sim le oiter

andCushing'ssyndrome.

.

andendocrinefunctiontests.

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11. Recognize the

endocrine

function

of

the; kidneys

Heart

Adiposetissues

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Course PBLSessions

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. .

2.Cushingssyndrome.

3.Diabetesmellitus.

4.Primaryinfertility.

th Elwathig)

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1. Studentsareexpectedtoattendlectures,tutorialsand

practical/studygroupsessions.

2. Failuretomeettheminimalattendancerequirements(75%ofecourseac v es mayresu nyou e ng eeme ne g e

forassessment.

.

withoutexcusewillnotbeallowedtositforthefinalexamand

will

be

deemed

fail.

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1.Readandfamiliarizehim/herwiththecontentsofthe

coursesyllabus.

2.Participateincourseactivitiesviaclassattendance,

discussion,and

note

taking,

seminar

preparation

and

presentation.

3.Readandstudyassignedreadingspriortobeingtested

over

the

material.

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Course Assessment

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Finalexamination:

accountsfor(70%)ofthetotalpoints

cons stso s ,s ortnotes ,

Thecontinuous

assessments:

accountsfor30%ofthetotalpoints

Include midcourse test re orts and PBL activities.

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Studentsscoreswillbegradedaccordingtothefollowing

scale.

core

Grade F C B B+ A

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Studentsfeedback(questionnaire).

Facultycommentsandobservations.

Analysisofexaminationresults.

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Course Timetable

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Davidson'sPrinciplesandPracticeofMedicine20thedition(2006).NicholasA.

, . . . .

HarpersIllustratedBiochemistry,28th edition(2009). RobertK.Murray,Victor

W.

Rodwell,

David

Bender,

Kathleen

M.

Botham,

P.

Anthony

Weil,

Peter

J.

enne y. as c c ence, c raw .

Biochemistry: ACaseOrientedApproach,6thEdition(1990).RexMontgomery,

Spector andThomasW.Conway.MosbyYearBook.

BaileyandLove'sShortPracticeofSurgery24edition(2007).R.C.G.Russell,

NormanWilliams

and

Christopher

J.K.

Bulstrode .

Oxford

University

Press.

ReviewofMedicalPhysiology,22ndEdition(2005).WilliamF.Ganong.LANGE

BasicScience,McGrawHill.

AnAidtoClinicalSurgery,6th edition(1998).PeterR.Scott(Author),B.P.

Waxman

Editor

RobinC.N.

Williamson

Editor .

Churchill

Livin stone.

McMinn's ColorAtlasofHumanAnatomy,4thedition(1998).P.H.Abrahams,

R.T.Hutchings,S.C.Marks.MosbyYearBook.

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atifkhirelsied@gmail.com

Scribed.com 4shared.com

Collagenmetabolism.

International

university

of

afrac