Download pdf - Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Transcript
Page 1: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

May24,2018

IntroductiontoGenomics

Malvika Pillai

Page 2: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

• WhatisGenomics?• GenomeSequencing• Genotyping

OutlineforIntroductiontoGenomics

Page 3: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

WhatisGenomics?

Page 4: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Collection ofinformation

Subsetofinformationtobeexpressed

Problem

Page 5: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

DefinitionofGenomics

Geno

mics

Functional

Comparative

Structural

etc.

• Large-scalestudyofgroupsofgeneswithinoneorganismorbetweenmultipleorganisms

Page 6: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

GenomeSequencing

Page 7: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

>NC_000017.11:c43125483-43044295 Homosapienschromosome17,GRCh38.p12PrimaryAssemblyGTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGCGACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGGGTAAAGGTAGTAGAGTCCCGGGAAAGGGACAGGGGGCCCAAGTGATGCTCTGGGGTACTGGCGTGGGAGAGTGGATTTCCGAAGCTGACAGATGGGTATTCTTTGACGGGGGGTAGGGGCGGAACCTGAGAGGCGTAAGGCGTTGTGAACCCTGGGGAGGGGGGCAGTTTGTAGGTCGCGAGGGAAGCGCTGAGGATCAGGAAGGGGGCACTGAGTGTCCGTGGGGGAATCCTCGTGATAGGAACTGGAATATGCCTTGAGGGGGACACTATGTCTTTAAAAACGTCGGCTGGTCATGAGGTCAGGAGTTCCAGACCAGCCTGACCAACGTGGTGAAACTCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGCCGCTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTAGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCGACAGAGCGAGACTGTCTCAAAACAAAACAAAACAAAACAAAACAAAAAACACCGGCTGGTATGTATGAGAGGATGGGACCTTGTGGAAGAAGAGGTGCCAGGAATATGTCTGGGAAGGGGAGGAGACAGGATTTTGTGGGAGGGAGAACTTAAGAACTGGATCCATTTGCGCCATTGAGAAAGCGCAAGAGGGAAGTAGAGGAGCGTCAGTAGTAACAGATGCTGCCGGCAGGGATGTGCTTGAGGAGGATCCAGAGATGAGAGCAGGTCACTGGGAAAGGTTAGGGGCGGGGAGGCCTTGATTGGTGTTGGTTTGGTCGTTGTTGATTTTGGTTTTATGCAAGAAAAAGAAAACAACCAGAAACATTGGAGAAAGCTAAGGCTACCACCACCTACCCGGTCAGTCACTCCTCTGTAGCTTTCTCTTTCTT

Whatisagenome?

Page 8: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

• Sangersequencing• NextGenerationSequencing(NGS)– IlluminaSequencingbySynthesis

Howdowesequenceagenome?

Page 9: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional
Page 10: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Genotyping

Page 11: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

Genotyping

Page 12: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

AnyQuestions?

Page 13: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

IntroductiontoGenomics:Demo+Hands-OnExercise

NextClass

Page 14: Introduction to GenomicsOutline for Introduction to Genomics. What is Genomics? Collectionof information Subset of information to be expressed Problem. Definition of Genomics s Functional

• MutatingRNAinMatlab– VisualizingRNAfolds– Comparingmutatedstrandstowildtypestrands

Demo


Recommended

CLC Genomics Workbench User Manual Subset
CLC Genomics Workbench User Manual Subset Documents
SystemC Synthesis Subset
SystemC Synthesis Subset Documents
Structural Genomics, ISGO, and Structural Genomics Task Forces Open ISGO Structural Genomics Task Force Meeting ISGO International Structural Genomics
Structural Genomics, ISGO, and Structural Genomics Task Forces Open ISGO Structural Genomics Task Force Meeting ISGO International Structural Genomics Documents
Subset Interval Groupoids
Subset Interval Groupoids Documents
Bayesian Subset Simulation
Bayesian Subset Simulation Education
SUBSET-026-8 v300
SUBSET-026-8 v300 Documents
SUBSET-023 v200.pdf
SUBSET-023 v200.pdf Documents
Genomics in Medicine: An Introduction to Genomics: Breast Cancer
Genomics in Medicine: An Introduction to Genomics: Breast Cancer Documents
Approximability of the Subset Sum Reconfiguration Problemerikdemaine.org/papers/SubsetSumReconfiguration_TAMC2011/...derived from the subset sum problem. The subset sum problem is
Approximability of the Subset Sum Reconfiguration Problemerikdemaine.org/papers/SubsetSumReconfiguration_TAMC2011/...derived from the subset sum problem. The subset sum problem is Documents
Subset Semirings
Subset Semirings Documents
Comparative Genomics. What is Comparative Genomics? It is the comparison of one genome to another. Genomics DNA (Gene) Functional Genomics TranscriptomicsRNA
Comparative Genomics. What is Comparative Genomics? It is the comparison of one genome to another. Genomics DNA (Gene) Functional Genomics TranscriptomicsRNA Documents
Functional Genomics brochuretdu.edu.in › tdusecond › wp-content › uploads › functionalgenomics_s… · Future of Functional Genomics (Transdisciplinary Genomics – I) Date:
Functional Genomics brochuretdu.edu.in › tdusecond › wp-content › uploads › functionalgenomics_s… · Future of Functional Genomics (Transdisciplinary Genomics – I) Date: Documents
Complete Subset Regressions
Complete Subset Regressions Documents
Forte New Subset List
Forte New Subset List Documents
 · Web viewGenetics and Genomics. Genetics and Genomics. Genetics and Genomics. Genetics and Genomics. Cell cycle, divisions, gametogenesis. Mutations and polymorphisms. Cytogenetics
 · Web viewGenetics and Genomics. Genetics and Genomics. Genetics and Genomics. Genetics and Genomics. Cell cycle, divisions, gametogenesis. Mutations and polymorphisms. Cytogenetics Documents
Functional genomics approaches to disease genomics
Functional genomics approaches to disease genomics Documents
23andMe, Pathway Genomics, Complete Genomics, Counsyl | Company Showdown
23andMe, Pathway Genomics, Complete Genomics, Counsyl | Company Showdown Business
Google Genomics Documentation - Read the Docsmedia.readthedocs.org/pdf/google-genomics/latest/google-genomics… · Google Genomics Documentation, Release v1 The 1000 Genomes Project
Google Genomics Documentation - Read the Docsmedia.readthedocs.org/pdf/google-genomics/latest/google-genomics… · Google Genomics Documentation, Release v1 The 1000 Genomes Project Documents