Related to liver inflammation disease
Hepaviridae family, hepevirius genus.
Transmitted through fecal-oral route.
Pregnancy,a most risk factor for HEV
HISTORYFirstly documented in
1955 in Delhi.MS Khuroo in 1980Dr.BayalanMajor Outbreaks
India 1955 Burma 1976 Kashmir 1978 China 1986 Maxico 1989
Signs and symptoms Incubation period It has 2 phases
Prodromal phase Arthralgia Mylegia Fever Anorexia Nausea/vomiting Dehydration
Icteric phase Jaundice Dark urine Light color stools Diarrhea Malaise Pruritus
Prevalence
GENOTY
PES O
F HEV
Genotype 1: has 5 subtypes
Genotype 2 : has 2 subtypes
Genotype 3 : has 10 subtypes
Genotype 4 : has 7 subtypes
GENOME OF HEV
Life cycle of hev
TRANSMISSION OF HEV
•Waterborne transmission• Zoonotic and foodborne
transmission• Vertical transmission• Person-to-person
transmission
DAIGNOSISELISART PCRImmunoflourescentImmune
electronmicroscopy
Treatment
Acute chronic
Treatment ??? Self limitingRibavirin(antiviral drug Interferon Serum immunoglobulin
Infections
PREVENTIONMaintaining
clean waterProper sanitationMaintaining
hygienic practicesAvoid eating
uncooked food
Vaccination
No commercialliazation Recombinant vaccine
Subunit hev vaccine
China,the only producer.