Slim-Excess®
Face and Body
Designer
2 BASF Personal Care
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Summary & Conclusion
BASF Personal Care 2
Fat & Face
BASF Personal Care
When fats accumulate in these pockets, the face
appears too round and its profile becomes
heavier.
How is fat distributed on our face?
& - two on the cheeks
& - two under the jaw
- one under the chin.
1 2
3 4 5
V-shape U-shape
Overtime facial bones and muscle fibers,
that hold fat pockets at the right places,
lose volume.
Fat shifts downward baggy chins and
jowls, double-chin.
20 60
3
Young
face
Aging
face
Superficial fat pads
V-shape physiology
BASF Personal Care 4
5 BASF Personal Care
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Summary & Conclusion
BASF Personal Care 5
Helping to "clear" excess
fat from the face
Slim-Excess®
The face designer
Slim-Excess™ turns “U” shape into “V” shape
for a more triangular & feminine lower face by:
Unveil a more feminine and younger face
Creating perfect V-shaped
contours from every facet
Refining and defining facial
contours on cheeks, jawline and
chin
U Face V Face
BASF Personal Care 6
Ingredient Presentation
Slim-Excess® : How does it work ?
fatty acid uptake lipid synthesis and triglyceride storage glucose uptake
cAMP signalling
Preadipocyte differentiation
Lipogenesis
Lipolysis
Adipogenesis
Spermine / Spermidine
SLIM-EXCESS®
Trapped polyamines
BASF Personal Care 7
Spermidine Slim-Excess®
sulfo-carrabiose
Slim-Excess®
Molecular modelling and interactions
Spermidine
Slim-
Excess® Slim-
Excess™
Spermidine
Slim-
Excess®
Interaction of one Slim-Excess® molecule
with one spermidine molecule
Interaction of three Slim-Excess® molecules
with one spermidine molecule
BASF Personal Care 8
9 BASF Personal Care
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Summary & Conclusion
BASF Personal Care 9
Slim-Excess® increases lipolysis by 87%.
Cultured adipocytes from abdominal biopsy, measurement of Free Fatty Acid release
Lipolysis
The Breakdown of Adipose Tissue
BASF Personal Care 10
Lipogenesis
The Production of Adipose Tissue
Cultured adipocytes from abdominal biopsy, measurement of radio-labeled acetate incorporation.
Slim-Excess® reduces lipogenesis by 79%.
BASF Personal Care 11
Pre-adipocyte
culture
Mature
adipocytes
Adipogenesis
Pre-adipocyte proliferation
Cultured adipocytes from abdominal biopsy, cell counting after 7 days.
Slim-Excess® reduces adipocyte proliferation by 35%.
BASF Personal Care 12
BASF Personal Care
In vivo study design
Protocol
* Same
concentration in
active matter as in
commercial product
Slim-Excess™
23-26 Chinese female volunteers over 45-year-old, with lack of firmness & slackening of facial skin as well as cheek and chin sagging
Randomized, double-blind, baseline-controlled full-face study
Twice daily-applications for 12 weeks of a serum containing Slim-Excess® 2%*
Evaluation time-points: baseline, 4, 8 and 12 weeks
Macrophotographs analysis
Biomechanical properties evaluation
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
13
BASF Personal Care
Cheek/chin angle (degree) from the front photographs of the face
Measurement of inflexion angle between the cheek and the chin.
All the results are expressed in percentage of modification versus D0.
An improvement is characterized by
an increase of the cheek/chin angle
Photographs analysis
Cheek/chin angle
14
< 180°
Increase of the chin/cheek
inflexion angle
=
Face contour correction
BASF Personal Care
Photographs analysis
Cheek/chin angle
Statistically significant
improvement of
cheek/chin angle
Slim-Excess®
significantly better
than the placebo
after 8 weeks
15
improves the
cheek/chin angle in
case of 82 % of the
volunteers.
BASF Personal Care
Double chin measurement (mm²) from the profile photographs of the face
The area of the double chin is defined by:
inflexion point between the chin and the double chin,
inflexion point between the neck and the double chin,
the profile of the double chin which will be modeled by a manual
capture and a polynomial interpolation.
All the results are expressed in percentage of modification versus D0.
An improvement is characterized by
a decrease of the double chin area
Photographs analysis
Double chin area
16
BASF Personal Care
Photographs analysis
Double chin area
Slim-Excess ®
demonstrated superior
activity comparatively to
placebo treatment.
Efficacy after 4 weeks 17
Statistically significant
decrease of double
chin surface
Principle: Contactless method
Application of the force (4g) between the times T0 and T1
Hold of the force between the time T1 and T2
Cut off the force at T2
Studied parameters:
Ratio Cr/Yf: express the elastic/viscous behavior
of the skin
A decrease of the ratio Cr/Yf express an improvement of skin elasticity
and a reduction of skin sagging behavior.
BASF Personal Care
Biomechanical properties evaluation
Tonoderm™ equipment
18
Slim-Excess® demonstrated superior activity comparatively to
placebo treatment
Biomechanical properties evaluation
Statistically
significant
decrease of the
ratio Cr/Yf
Skin elasticity
Skin sagging
BASF Personal Care 19
Baseline Baseline 12 weeks
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
Volunteer result examples
Slim-Excess ® 2%
Clear visible results
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
12 weeks
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
© B
AS
F B
eauty
Care
Solu
tions F
rance S
AS
-12% double chin
area
Cheek/chin angle
improved by +5%
BASF Personal Care 20
21 BASF Personal Care
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Summary & Conclusion
BASF Personal Care 21
BASF Personal Care 22
In vitro
In vivo
Increases lipolysis (the breakdown of fat) by 87%
Decrease in lipogenesis (fat production) by 79%
Decrease in adipogenesis (fat cell proliferation and maturation) by 35% a
Improvement of chin/cheek angle (indicating proper “v-shaping” effect) in
over 82% of volunteers and was statistically significant in comparison to
placebo
Decrease in double chin surface area found in over 63% of volunteers and
was statistically significant
Improvement in skin elasticity and reduction in skin sagging
Slim-Excess®
Summary of Tests – Face
BASF Personal Care 23
INCI: Water (and) Butylene Glycol (and) Pentylene
Glycol (and) Sodium Chloride (and) Hydrolyzed
Rhodophycea Extract (and) Xanthan Gum
Dose of use: 2-3%
Solubility: water-soluble liquid
Shelf life: 12 months
Preservatives: none
Product Properties
China/ Japan Regulations
Benefits & Unique Selling Points
Targets a unique set of polyamines for inhibition of excess fat
production
Controls fat production through three pathways: increases the
breakdown of fat, inhibits fat production, and inhibits fat cell
proliferation and maturation
Visibly improves facial contour and reduces sagging skin, jowls, and
double chin
Formula suggestions: Facial Sculpting Cream SC-US-14-31208-34-1, Vibrant Glow
Renewal SC-US-31208-33-1
Body Care
Applications
Face Care Wipes Anti-Aging
Care
Formulation Instructions
Incorporate into water phase below 80◦C or at room temperature with
cold processing.
Firming
Care
Slim-Excess®
The face & body designer
PCPC INCI 2007 INCI 2010 Not Listed
Jap.
Pharma.
IECIC
2014
BASF Personal Care 24
Facial Sculpting Cream
Formula Chisel age away as you smooth fine lines and sagging skin. This sculpting cream visibly transforms
your facial contour as it lifts, tones, and illuminates to accentuate cheekbones and the jawline.
This document, or any answers or information provided herein by BASF, does not constitute a legally binding
obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith
and believed to be accurate, they are provided for your guidance only. Because many factors may affect processing
or application/use, we recommend that you make tests to determine the suitability of a product for your particular
purpose prior to use. It does not relieve our customers of the obligation to perform a full inspection of the products
upon delivery or any other obligation. The claims and supporting data provided in this publication have not been
evaluated for compliance with any jurisdiction’s regulatory requirements and the results reported may not be generally
true under other conditions or in other matrices. Users must evaluate what claims and information are appropriate and
comply with a jurisdiction’s regulatory requirements. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR
IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE
MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT
THE PRODUCTS, DESIGNS, DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE
INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION,
DATA, OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERM SAND CONDITIONS OF SALE.
DISCLAIMER
BASF Personal Care 25