BioMed Central
Page 1 of 1(page number not for citation purposes)
BMC Bioinformatics
Open AccessPoster presentationExploring Parasite Gene SpaceJames Wasmuth*, Ralf Schmid, Alasdair Anthony, John Parkinson and Mark Blaxter
Address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
Email: James Wasmuth* - [email protected]
* Corresponding author
Funding allocation for complete genome sequencing hasa severe taxonomic bias; nearly half of the completed ordraft stage genomes are from vertebrates. The luxury of afull genome sequence is unlikely to be available for thevast majority of organisms, regardless of their importancein terms of evolution, health or ecology. This has lead tothe investigation of genomes from an increasing numberof species, especially parasites, through generation ofexpressed sequence tags (ESTs).
Over 300,000 ESTs are available for 36 species of parasiticnematode. The species include whipworm and filarialworms, which currently infect 3 bn people, as well as alarge number of plant parasites. We have constructedNEMBASE, a database and analysis suite that integratesthese transcriptomes with associated annotation andmeta-data www.nematodes.org. The system enables com-parative transcriptomic analyses across the phylum Nem-atoda. At present we are focusing upon differences bothbetween and within the parasitic and free-living species.This has led to the discovery of greatly expanded proteinfamilies and novel protein domains that will provide pos-sible drug targets for lab verification.
from BioSysBio: Bioinformatics and Systems Biology ConferenceEdinburgh, UK, 14–15 July 2005
Published: 21 September 2005
BMC Bioinformatics 2005, 6(Suppl 3):P27<supplement> <title><p>BioSysBio: Bioinformatics and Systems Biology Conference</p></title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1471-2105-6-S3-full.pdf">here</a>.</note> <url>http://www.biomedcentral.com/content/pdf/1471-2105-6-S3-info.pdf</url> </supplement>
Recommended
