BioMed Central Page 1 of 1 (page number not for citation purposes) BMC Bioinformatics Open Access Poster presentation Exploring Parasite Gene Space James Wasmuth*, Ralf Schmid, Alasdair Anthony, John Parkinson and Mark Blaxter Address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK. Email: James Wasmuth* - [email protected] * Corresponding author Funding allocation for complete genome sequencing has a severe taxonomic bias; nearly half of the completed or draft stage genomes are from vertebrates. The luxury of a full genome sequence is unlikely to be available for the vast majority of organisms, regardless of their importance in terms of evolution, health or ecology. This has lead to the investigation of genomes from an increasing number of species, especially parasites, through generation of expressed sequence tags (ESTs). Over 300,000 ESTs are available for 36 species of parasitic nematode. The species include whipworm and filarial worms, which currently infect 3 bn people, as well as a large number of plant parasites. We have constructed NEMBASE, a database and analysis suite that integrates these transcriptomes with associated annotation and meta-data www.nematodes.org . The system enables com- parative transcriptomic analyses across the phylum Nem- atoda. At present we are focusing upon differences both between and within the parasitic and free-living species. This has led to the discovery of greatly expanded protein families and novel protein domains that will provide pos- sible drug targets for lab verification. from BioSysBio: Bioinformatics and Systems Biology Conference Edinburgh, UK, 14–15 July 2005 Published: 21 September 2005 BMC Bioinformatics 2005, 6(Suppl 3):P27 <supplement> <title><p>BioSysBio: Bioinformatics and Systems Biology Conference</p></title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1471-2105-6-S3-full.pdf">here</a>.</note> <url>http://www.biomedcentral.com/content/pdf/1471-2105-6-S3-info.pdf</url> </supplement>

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BioMed Central

Page 1 of 1(page number not for citation purposes)

BMC Bioinformatics

Open AccessPoster presentationExploring Parasite Gene SpaceJames Wasmuth*, Ralf Schmid, Alasdair Anthony, John Parkinson and Mark Blaxter

Address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.

Email: James Wasmuth* - [email protected]

* Corresponding author

Funding allocation for complete genome sequencing hasa severe taxonomic bias; nearly half of the completed ordraft stage genomes are from vertebrates. The luxury of afull genome sequence is unlikely to be available for thevast majority of organisms, regardless of their importancein terms of evolution, health or ecology. This has lead tothe investigation of genomes from an increasing numberof species, especially parasites, through generation ofexpressed sequence tags (ESTs).

Over 300,000 ESTs are available for 36 species of parasiticnematode. The species include whipworm and filarialworms, which currently infect 3 bn people, as well as alarge number of plant parasites. We have constructedNEMBASE, a database and analysis suite that integratesthese transcriptomes with associated annotation andmeta-data www.nematodes.org. The system enables com-parative transcriptomic analyses across the phylum Nem-atoda. At present we are focusing upon differences bothbetween and within the parasitic and free-living species.This has led to the discovery of greatly expanded proteinfamilies and novel protein domains that will provide pos-sible drug targets for lab verification.

from BioSysBio: Bioinformatics and Systems Biology ConferenceEdinburgh, UK, 14–15 July 2005

Published: 21 September 2005

BMC Bioinformatics 2005, 6(Suppl 3):P27<supplement> <title><p>BioSysBio: Bioinformatics and Systems Biology Conference</p></title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1471-2105-6-S3-full.pdf">here</a>.</note> <url>http://www.biomedcentral.com/content/pdf/1471-2105-6-S3-info.pdf</url> </supplement>

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