EXPOSING HARMFUL INGREDIENTS INDIETARY SUPPLEMENTS

EXPOSING HARMFUL INGREDIENTS INDIETARY SUPPLEMENTS

NOT THE FIRST TIME: NSF researchers havefound potentially harmful compounds in supplements on four occasions.

2016 2014

2013 2013

OxilofrineDMBA

DMAA DEPEA

PHARMACOLOGIC EFFECTSSIMILAR TO DMAA AND EPHEDRINE

Researchers at NSF International recently identi�ed unlabeledDMAA-like stimulants in over-the-counter weight-loss andpre-workout products currently available worldwide.1

Game Day

Infrared

2-aminoisoheptane

Simply Skinny Pollen

Cannibal Ferox AMPED

Triple X Gold Star

Chaos and Pain

Bee Fit with Trish

Chaos and Pain

Gold Star

MAN Sports Octodrine

1,3-DMAA*

1,4-DMAA

1,3-DMAA*1,4-DMAA

1,3-DMBA*

1,4-DMAA

Product Manufacturer Unapproved Compounds

*Previously found to be unlawful dietary ingredient by the U.S. FDA

Products Tested

2-AMINOISOHEPTANE A. KUSNEZOFFII

© 2017 NSF International. All rights reserved.

1 Four experimental stimulants found in sports and weight-loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA). Clinical Toxicology.www.tandfonline.com/doi/full/10.1080/15563650.2017.1398328.

2 Potentially Harmful Adulterant Called N,alpha-diethylphenylethylamine (N,a-DEPEA) Found in a Dietary Supplement. NSF International website.www.nsf.org/newsroom/emerging-and-potentially-harmful-adulterant-depea-found-in-supplements. Accessed June 5, 2017.

3 DMAA in Dietary Supplements. U.S. Food and Drug Administration website. www.fda.gov/food/dietarysupplements/productsingredients/ucm346576.htm. Accessed June 5, 2017.

4 DMBA in Dietary Supplements. U.S. Food and Drug Administration website. www.fda.gov/food/dietarysupplements/productsingredients/ucm444719.htm. Accessed June 5, 2017.

5 Scientists at NSF International say oxilofrine could be disguised or unlisted on the label and pose serious health risks to consumers.NSF International website. www.nsf.org/newsroom/unapproved-ephedrine-like-stimulant-oxilofrine-found-in-14-dietary-suppleme.Accessed June 5, 2017.

6 Supplements and Health: Sorting the Facts. Harvard T.H. Chan School of Public Health website.https://theforum.sph.harvard.edu/events/supplements-and-health. Accessed June 5, 2017.

DMAA DMBA

ILLEGAL INGREDIENTS

1,4-DMAA Octodrine

UNAPPROVED INGREDIENTS

HIDDEN STIMULANTS: WHAT ARE THE RISKS?

DEPEA – Risk of heart attack.2

DMAA – Elevated blood pressure andcardiovascular problems.3

DMBA – Risk of heart attacks, seizuresand neurological conditions.4

Oxilofrine – Nausea and vomiting, tachycardia, chest pain and cardiac arrest.5

CARDIOVASCULAR RISKS INCREASE WHENPRODUCTS COMBINED WITH CAFFEINE OR EXERCISE.

High-Risk Categories of Supplements6

Weight loss Pre-workoutMusclebuilding

Sexualperformance

HOW TO CHOOSESAFER DIETARY SUPPLEMENTS

Avoid productscontaining

“2-aminoisoheptane”or “Aconitumkusnezof�i”

Look for theNSF mark

on certi�eddietary

supplements

“2-aminoisoheptane” and “Aconitum kusnezoffii” appear to be

new disguises for illegal and unapproved synthetic stimulants.1

DISGUISING HARMFUL INGREDIENTS

DMAA Octodrine

DMBA1,4-DMAA

2-aminoisoheptane2-aminoisoheptane

NSF-CERTIFIED PRODUCTS ARE:

Tested to verify product formulation and label claims.

Tested for harmful levels of specific contaminants and fraudulent ingredients.

Produced in manufacturing facilities that are inspected twice a year to complywith U.S. FDA Good Manufacturing Practices (GMPs).

Unapproved stimulants found in productscontaining “2-aminoisoheptane” and “Aconitum kusnezof�i.”

A New DMAA Analog1,4-DMAA appears to be a novel compound

never tested on humans. This newly identified

compound is similar to the stimulant DMAA.

NSF’s research team sees no evidencethat 2-aminoisoheptane is a legitimatedietary ingredient derived from plants.1

Aconitumkusnezoffii