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Red Blood Cells
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Function:
Transport O2 (98,5 %)
Transport CO2 Buffer through:
• !"co!"tic en#"$e
• caronic anh"&rase en#"$e
ERYTHROCYTES
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hape an& i#e : Biconcae &isc * +,8 $, a thic-ness of 2,5
$, . 1 $ in the center
/o!u$e 0 9 95 $'
3erage nu$er 4BCs : en : 56267$$' (. '67$$')
o$en : 6+67$$' (. '67$$')
Concentration : en 15 gra$7&! or 15 gr71 $!
o$en 1 gra$7&! or 1 gr71 $!
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;$r"onic "o!- sac
Tri$ester
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Relative rates of red blood cell production in te
bone !arro" of different bones at different a#es
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Sta#es of differentiation of Red Blood Cells
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Sta#es of differentiation of RedBlood Cells
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• The tota! $ass of re& !oo& ce!!s in the
circu!ator" s"ste$ is regu!ate& >ithin
narro> !i$its, so that :
16 3n a&e@uate nu$er of re& ce!!s is
a!>a"s aai!a!e to proi&e sufficient
transport of oA"gen fro$ the !ungs to the
tissue26 The ce!!s &o not eco$e so nu$erous
that the" i$pe&e !oo& f!o>
Re#ulation of Red Blood Cells
Production
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$% Tissue o&'#enation is te !ost essentialre#ulator of Red Blood Cell Production
Tissue O2 ↓ pro&uct 4BC ↑
e6g: 3ne$ia : he$orrhage
Ara" therap" igh a!titu&e (O2) ↓
O2 transport ↓ pro&uct 4BC ↑ /arious &isease of the circu!ation that
cause &ecrease& !oo& f!o> through theperiphera! esse!s
e6g : eart Fai!ure
=ung &isease
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26 ;r"thropoietin sti$u!ates re& ce!! pro&uction• The principa! sti$u!us for re& !oo& ce!!
pro&uction in !o> oA"gen states is acircu!ating hor$one ca!!e& erythropoietin (ag!"coprotein >ith a $o!ecu!ar >eight of aout'6)
•
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Er'tropoiesis is controlled b' er'tropoietin fro! te (idne's
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3t the other eAtre$e, >hen !arge @uantities of
er"thropoietin are for$e& aai!a!e, an& ifthere is p!ent" of iron an& other re@uire&
nutrients aai!a!e, the rate of re& !oo& ce!!s
pro&uction can rise to perhaps 1 or $oreti$es nor$a!