05. Red Blood Cells1

8/17/2019 05. Red Blood Cells1

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Red Blood Cells


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Function:

Transport O2 (98,5 %)

Transport CO2 Buffer through:

• !"co!"tic en#"$e

• caronic anh"&rase en#"$e

ERYTHROCYTES


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hape an& i#e : Biconcae &isc * +,8 $, a thic-ness of 2,5

$, . 1 $ in the center

/o!u$e 0 9 95 $'

3erage nu$er 4BCs : en : 56267$$' (. '67$$')

o$en : 6+67$$' (. '67$$')

Concentration : en 15 gra$7&! or 15 gr71 $!

o$en 1 gra$7&! or 1 gr71 $!


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;$r"onic "o!- sac

Tri$ester


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Relative rates of red blood cell production in te

bone !arro" of different bones at different a#es


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Sta#es of differentiation of Red Blood Cells


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Sta#es of differentiation of RedBlood Cells


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• The tota! $ass of re& !oo& ce!!s in the

circu!ator" s"ste$ is regu!ate& >ithin

narro> !i$its, so that :

16 3n a&e@uate nu$er of re& ce!!s is

a!>a"s aai!a!e to proi&e sufficient

transport of oA"gen fro$ the !ungs to the

tissue26 The ce!!s &o not eco$e so nu$erous

that the" i$pe&e !oo& f!o>

Re#ulation of Red Blood Cells

Production


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$% Tissue o&'#enation is te !ost essentialre#ulator of Red Blood Cell Production

Tissue O2 ↓ pro&uct 4BC ↑

e6g: 3ne$ia : he$orrhage

Ara" therap" igh a!titu&e (O2) ↓

O2 transport ↓ pro&uct 4BC ↑ /arious &isease of the circu!ation that

cause &ecrease& !oo& f!o> through theperiphera! esse!s

e6g : eart Fai!ure

=ung &isease


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26 ;r"thropoietin sti$u!ates re& ce!! pro&uction• The principa! sti$u!us for re& !oo& ce!!

pro&uction in !o> oA"gen states is acircu!ating hor$one ca!!e& erythropoietin (ag!"coprotein >ith a $o!ecu!ar >eight of aout'6)

•


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Er'tropoiesis is controlled b' er'tropoietin fro! te (idne's


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3t the other eAtre$e, >hen !arge @uantities of

er"thropoietin are for$e& aai!a!e, an& ifthere is p!ent" of iron an& other re@uire&

nutrients aai!a!e, the rate of re& !oo& ce!!s

pro&uction can rise to perhaps 1 or $oreti$es nor$a!

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05. Red Blood Cells1