Your first mentored grant proposal:

The National Institutes of Health

F and K proposals

Alison K. Hall, Ph.D.

Case School of Medicine

Office of Graduate Education

Committee on National Needs for Biomedical and Behavioral Scientists, a unit of the National Research Council, the operating arm of the National Academy of Sciences.

Estimates that there are some 52,000 postdocs in the country (2001)

3/4 in life sciences, half from foreign countries

Postdoctoral trainess at Case SOM, Spring 2005

Total SOM Male Female

Postdoc Scholar

30 18 12

Postdoc Fellow

81 48 33

Research Associate*

277 160 117

Senior

Research Associate*

57 33 24

Many are planning independent careers

Postdocs are at a critical juncture in training

productive

self-reliant

about to embark on independent careers

Often write a grant to seek financial support and recognition for their research

Why do you want a mentored grant?

1. Makes the relationship with the PI explicit

2. Benefits associated with grant

3. Looks good on your resume

4. Great learning experience

5. Not ready for the R01…

Where do you start?

Communicateyour PI, potential mentors/committeeyour chairpersonthe Office of Research

Are you ready?pilot datatime to focusappointment statusdeadlines

Do you qualify?

Not every Institute has these mechanisms

Restricted to US citizens, permanent residents

The F32 NRSA

individuals seeking posdoctoral research training in the basic and clinical sciences

F32->RO1

set stipend scale and supplement

The F32 NRSA February 4, 2005Stipends for Kirschstein-NRSA awards 2005PostdoctoralYears of Experience:0   $ 35,5681   $ 37,4762   $ 41,7963   $ 43,4284   $ 45,0485   $ 46,9926   $ 48,8527 or more $ 51,036

Program announcements http://grants.nih.gov/training/nrsa.htm

Institutional Allowance $5,500 Research supplies, health insurance, travel to mtgs

2002 Number number total cost success reviewed awarded awarded 1000s rate*

MD 202 91 4,602 45  PHD 1,336 516 20,813 38.6   all 1,538 607 25,415 39.5

Percentage that receive funding in a year (a resubmission is only counted the first time)

http://grants.nih.gov/grants/award/training/F32MDPHD9502.HTM

The F32 NRSA is a reasonable goal:Success rates on Individual Postdoc Fellowship applications

Prepare the Application: read the instructions!!start early, seek internal reviewers

a. Candidate (grades, GREs, etc)a. US citizen or permanent residentb. Doctoral degree (many ok)

b. Sponsor and Training Environment c. Research Proposal

a. Up to 3 yrsc. Training Potentiald. Vertebrate Animals, Human Subjects etc.e. 3 times per year, usu Feb1, June1, Oct 1

The A1 or A2. You may have to resubmit…

http://grants.nih.gov/training/nrsa.htm

The F32 NRSA success is about 30%

http://grants.nih.gov/training/data/tf_trends/sld006.htm

http://grants.nih.gov/training/data/tf_trends/sld006.htm

Postdoctoral trainees are funded by many Institutes

1F30NS050913-01 Assistive Device Control With Brain Surface Signals5F30ES011931-03 Initiation of Experimental Colitis by Commensal Flora1F31HD049326-01 Upper Extremity Control Using Reinforcement Learning1F31MH073296-01 Molecular Genetics of the Serotonin System1F31NR009344-01 Dance and Physical Activity in African American Women5F31HD041926-03 PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES1F31MH074241-01 ERK2 Specific Function of the CNS5F31NR007943-04 Kangaroo Care Effects on post/cath stabilization

1F32GM074554-01 Creation of designer biogenic amine receptors1F32AG024031-01A1Mechanisms of Abeta-Stimulated ROS in Microglia 5F32EB003363-02 Group Theory Applied to rf Coil Design

Predoctoral (Graduate Students!)

Postdoctoral

Case has few F awards

http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen

Grantwriting Resources

Grantpersonship: An Instruction Manualhttp://www.pitt.edu/~survival

NIMH Grant Application Processhttp://www.nimh.nih.gov/researchFunding/grantprocess.cfmhttp://www.nimh.nih.gov/researchFunding/training.cfm

FASEB Grantsmanship Training Programhttps://ns2.faseb.org/careerutilities/grantprg.htm

Grant Application Writer’s Handbook, Reif-Lehrer

The K08

For clinically trained persons to pursue research careersin basic or clinical sciences.

Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship)

Mentored Clinical Scientist Development AwardK08->K02-> R01up to $85,000 salary up to $50,000 costs per yearup to five years, non-renewable

The K08

Prepare the Application: read the instructions!!

a. Candidateb. Research Planc. Career Development Plan/ Training Pland. Environment/ Institutional supporte. Mentor*f. Vertebrate Animals, Human Subjects etc.g. The A1 or A2. You may have to resubmit…h. (The summary statement)

The K08

1. Candidate**

2. Basic Science Mentor/co Mentor:

1. Good working relationship

2. Often funded by NIH

3. Expert in this area

4. Experienced trainer

**some Institutes require faculty appointment (eg Instructor)

The K08

3. Career Development Plan (very important)

• Focused and relevant

• New techniques, new area, could be funded

• Present at meetings, review grants, external courses

• Update didactics

• Create an oversight committee familiar with research, career goals, meet six mos for feedback

4. Research Plan

• Provide preliminary data to support rationale, approach. Focus!

• Include study of Research Ethics, animals etc.

The K08

http://grants.nih.gov/grants/guide/pa-files

See supplementary info at each institute

Insure protected time-Do not assume that 75% means anythingexcept 75% of your total working hours

-These estimates are carefully reviewedessential that your chair state thisnot contingent on receipt of the grant

-50% Neurosurgery

What happens to your application after it leaves the mailbox?

Scientific Review Group in Center for Scientific ReviewStudy section review

supplementsScores and percentilesSummary sheet

Inside the NIH Grant Review Process

39 min video NIH Center for Scientific Review

Includes R01/K08/ R03

Download proposals

http://www.drg.nih.gov/Video/video.asp#docs

View the video on the web

http://www.drg.nih.gov/Video/Video.asp

Helpful Hints for an NLHBI K08 Application http://www.nhlbi.nih.gov/funding/training/redbook/hints.htm

1K08HL073240-01A1Medullary GABAergic Neurons in Neonatal Reflex Apnea5K08AI001581-05 CD8+ T CELLS AND MYCOPLASMA TUBERCULOSIS5K08CA084337-06 ERBB2 KINASE SIGNALING IN COLON CARCINOGENESIS5K08DK059488-04 The Role of TGF-alpha in the Pathogenesis of ARPKD5K08DK002699-05 QUANTITATIVE EXPRESSION LIBRARIES TO IDENTIFY ESRD GENES5K08MH068584-02 Youth Subjective Experience of Psychotropic Treatment5K08HL004299-05 PULMONARY IMMUNE DEFENCES AGAINST M. BOVIS-BCG INFECTION5K08AI054652-02 Innate immune responses in lymphatic filariasis1K08HD047431-01 Metabolic Requirements for Oogenesis and Embryogenesis5K08AI051565-03 Immunologic Studies of Endemic Burkitt's Lymphoma5K08NS046486-02 Systemic perinatal insults disrupt neurodevelopment5K08NS041594-03 The Role of PPAR Agonists in Inflammation and stroke

K08 awards at Case

http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen